NEWS HIGHLIGHTSMedia Articles Related to Metastron (Strontium Chloride, SR-89)
Opiate Painkillers May Encourage Spread Of Cancer
Source: Health News from Medical News Today [2009.11.23]
New research from the US adds weight to the growing body of evidence that opiate-based painkillers like morphine, which has been used to treat postoperative and chronic cancer pain for two hundred years, encourage cancer cells to grow and spread.
62-Year-Old Man Becomes First Patient In China Implanted With Rechargeable Neurostimulator For Chronic Pain
Source: Medical Devices / Diagnostics News From Medical News Today [2009.11.19]
St. Jude Medical, Inc. (NYSE:STJ) announced that a 62-year-old man from Shenzhen, Guangdong province has become the first patient in China to be implanted with the Eon™ neurostimulator, a rechargeable device used to help manage chronic pain. Despite prior back surgeries, the patient suffered from chronic back pain for more than a decade.
CNSBio Inc. To Present Latest Clinical Trial Data For CNSB015 At Neuropathic Pain Conference In San Francisco
Source: Pain / Anesthetics News From Medical News Today [2009.11.19]
CNSBio Inc. will present recent Phase IIa proof-of-concept clinical trial data for CNSB015, an orally administered potassium channel modulator used in combination with opioids for the treatment of neuropathic pain, at the 12th International Conference on the Mechanisms and Treatment of Neuropathic Pain on November 20-21, 2009 in San Francisco, CA. Dr.
Common Pain Relief Medication May Encourage Cancer Growth
Source: Pain / Anesthetics News From Medical News Today [2009.11.19]
Although morphine has been the gold-standard treatment for postoperative and chronic cancer pain for two centuries, a growing body of evidence is showing that opiate-based painkillers can stimulate the growth and spread of cancer cells. Two new studies advance that argument and demonstrate how shielding lung cancer cells from opiates reduces cell proliferation, invasion and migration in both cell-culture and mouse models.
Transplanting People's Own Stem Cells Into Heart Lessens Pain, Improves Ability To Walk
Source: Pain / Anesthetics News From Medical News Today [2009.11.19]
The largest national stem cell study for heart disease showed the first evidence that transplanting a potent form of adult stem cells into the heart muscle of subjects with severe angina results in less pain and an improved ability to walk. The transplant subjects also experienced fewer deaths than those who didn't receive stem cells.
Published Studies Related to Metastron (Strontium Chloride, SR-89)
Palliation of bone pain in prostate cancer using chemotherapy and strontium-89. A randomized phase II study. [2005.04]
Strontium-89 is an established alternative for the alleviation of bone pain in prostate cancer. There are few data evaluating the effect on pain of palliative chemotherapy...
Clinical effectiveness of a strontium chloride- containing desensitizing agent over 6 months: a randomized, double-blind, placebo-controlled study. [2008.04]
CONCLUSION: Use of SR for desensitizing hypersensitive dentin is an effective alternative to existing desensitizing agents.
Strontium oral load test in children with idiopathic hypercalciuria. [2007.09]
Increased intestinal calcium absorption may play an important role in the pathogenesis of idiopathic hypercalciuria in children. Calcium absorption was assessed by an oral strontium load test in 22 prepubertal children (13 male) with idiopathic hypercalciuria, urinary calcium excretion 6.48 +/- 0.60 mg/kg per day (range 4.12-13.40 mg/kg per day), and ten healthy, young, normocalciuric controls (six male)...
Changes in the levels of CD4+ and CD8+ T-lymphocytes after strontium-89 chloride therapy for painful bone metastases in patients correlate with treatment efficacy. [2007.06]
The aim of this study was to evaluate changes in the peripheral blood CD(4)(+) and CD(8)(+) T-lymphocyte populations following strontium-89 chloride ((89)SrCl(2)) therapy for painful bone metastases and to relate these changes to a therapeutic response... The ratio of CD(4)(+) to CD(8)(+) T-lymphocytes correlated strongly with the response of bone metastases to (89)SrCl(2), and therefore, may be used as an indicator of (89)SrCl(2) efficacy.
[Therapeutic efficacy of strontium-89-chloride for bone metastatic tumors without bone pain] [2007.03]
OBJECTIVE: To evaluate the safety and efficacy of strontium-89-chloride for management of bone metastases in patients without bone pain... CONCLUSION: Strontium-89-chloride is effective and safe for treatment of nonpainful bone metastases.
Clinical Trials Related to Metastron (Strontium Chloride, SR-89)
Docetaxel and Prednisolone With or Without Zoledronic Acid and/or Strontium Chloride Sr 89 in Treating Patients With Prostate Cancer Metastatic to Bone That Has Not Responded to Hormone Therapy [Recruiting]
RATIONALE: Drugs used in chemotherapy, such as docetaxel and prednisolone, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Zoledronic acid may help relieve some of the symptoms caused by bone metastases.
Radioactive substances, such as strontium chloride Sr 89, may help relieve bone pain caused
by prostate cancer. Giving docetaxel together with prednisolone with or without zoledronic
acid and/or strontium chloride Sr 89 may kill more tumor cells.
PURPOSE: This randomized phase II trial is studying the side effects and how well giving
docetaxel together with prednisolone works with or without zoledronic acid and/or strontium
chloride Sr 89 in treating patients with prostate cancer metastatic to bone that has not
responded to hormone therapy.
2PX (Topical Strontium Chloride Hexahydrate) in Patients With Post-Amputation Stump Pain. [Completed]
Strontium Compared With Radiation Therapy in Treating Patients With Hormone-Refractory Prostate Cancer With Painful Bone Metastases [Active, not recruiting]
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and either kill them or
deliver tumor-killing substances to them without harming normal cells. This may be an
effective treatment for prostate cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of strontium or radiation
therapy in treating patients with prostate cancer that is refractory to hormone therapy who
have painful bone metastases.
A Study of the Efficacy and Safety of 2PX in Patients With Pain Due to Osteoarthritis of the Knee [Recruiting]
Study of the Efficacy, Safety and Tolerability of Topical 2PX (Strontium Chloride Hexahydrate) in Patients With Chronic, Moderate-to-severe Lower Limb Post-amputation Stump Pain [Recruiting]
Primary: To compare the analgesic effect over 12 weeks of topical 2PX in stump pain.
Secondary: To prospectively measure other efficacy and safety variables of topical 2PX in
stump pain. Exploratory analyses will be performed to measure efficacy and safety variables
of topical 2PX in phantom pain
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