NEWS HIGHLIGHTSMedia Articles Related to Metastron (Strontium Chloride, SR-89)
Constant Pain a Big Problem in Older Adults (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2013.05.11]
NEW ORLEANS (MedPage Today) -- Nearly 19 million older adults in the U.S. reported bothersome pain in the previous month, according to researchers here.
Copper IUDs Not Associated With Increased Menstrual Pain
Source: Medscape Medical News Headlines [2013.05.10]
Copper IUDs are not linked with increased dysmenorrhea severity; a hormone-releasing system has been linked to reduced menstrual pain.
Medscape Medical News
Fun And Friends Help Ease The Pain Of Breast Cancer
Source: Health News from Medical News Today [2013.05.10]
Kaiser Permanente study among the first to examine how social relationships influence quality of life in breast cancer patients Breast cancer patients who say they have people to have a good time, or "positive social interactions," with are better able to deal with pain and other physical symptoms, according to a new Kaiser Permanente study published this week in Breast Cancer Research and Treatment. "This study provides research-based evidence that social support helps with physical symptoms," said lead author Candyce H...
Copper IUD Does Not Increase Period Pain
Source: Health News from Medical News Today [2013.05.10]
Previous scientific studies have suggested that women who use a copper IUD for contraception suffer from worse period pain, but a study at the Sahlgrenska Academy, University of Gothenburg, that followed 2,100 women over a 30-year period shows that this is not the case. In the study, 19-year-olds born in 1962, 1972 and 1982 were asked questions about their height, weight, pregnancies, children, period pain and contraception...
Inflammation Continues in Chronic Pain Patients (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2013.05.10]
NEW ORLEANS (MedPage Today) -- Even after long-term treatment with opioids, inflammation persists in many chronic pain patients as evidenced by C-reactive protein levels and erythrocyte sedimentation rate, a California researcher reported here.
Published Studies Related to Metastron (Strontium Chloride, SR-89)
Efficacy of a commercial dentifrice containing 2% strontium chloride and 5%
potassium nitrate for dentin hypersensitivity: a 3-day clinical study in adults
in China. [2012]
silica base without any active ingredient (control dentifrice)... CONCLUSION: In these patients with DH in China, the dentifrice containing 2%
Palliation of bone pain in prostate cancer using chemotherapy and strontium-89. A randomized phase II study. [2005.04]
Strontium-89 is an established alternative for the alleviation of bone pain in prostate cancer. There are few data evaluating the effect on pain of palliative chemotherapy...
Complete regression of multiple painful bone metastases from hepatocellular carcinoma after administration of strontium-89 chloride. [2010.10]
A 69-year-old man received strontium-89 chloride intravenous injection to relieve uncontrollable pain from multiple hepatocellular carcinoma bone metastases. Pain was resolved 3 months later without opioid analgesics... The patient lived for 1 year without recurrence of bone metastasis.
Clinical effectiveness of a strontium chloride- containing desensitizing agent over 6 months: a randomized, double-blind, placebo-controlled study. [2008.04]
CONCLUSION: Use of SR for desensitizing hypersensitive dentin is an effective alternative to existing desensitizing agents.
Strontium oral load test in children with idiopathic hypercalciuria. [2007.09]
Increased intestinal calcium absorption may play an important role in the pathogenesis of idiopathic hypercalciuria in children. Calcium absorption was assessed by an oral strontium load test in 22 prepubertal children (13 male) with idiopathic hypercalciuria, urinary calcium excretion 6.48 +/- 0.60 mg/kg per day (range 4.12-13.40 mg/kg per day), and ten healthy, young, normocalciuric controls (six male)...
Clinical Trials Related to Metastron (Strontium Chloride, SR-89)
Docetaxel and Prednisolone With or Without Zoledronic Acid and/or Strontium Chloride Sr 89 in Treating Patients With Prostate Cancer Metastatic to Bone That Has Not Responded to Hormone Therapy [Recruiting]
RATIONALE: Drugs used in chemotherapy, such as docetaxel and prednisolone, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Zoledronic acid may help relieve some of the symptoms caused by bone metastases.
Radioactive substances, such as strontium chloride Sr 89, may help relieve bone pain caused
by prostate cancer. Giving docetaxel together with prednisolone with or without zoledronic
acid and/or strontium chloride Sr 89 may kill more tumor cells.
PURPOSE: This randomized phase II trial is studying the side effects and how well giving
docetaxel together with prednisolone works with or without zoledronic acid and/or strontium
chloride Sr 89 in treating patients with prostate cancer metastatic to bone that has not
responded to hormone therapy.
2PX (Topical Strontium Chloride Hexahydrate) in Patients With Post-Amputation Stump Pain. [Completed]
Chemotherapy With or Without Strontium-89 in Treating Patients With Prostate Cancer [Recruiting]
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Radioactive substances such as strontium-89 may relieve bone
pain associated with prostate cancer. It is not yet known whether chemotherapy is more
effective with or without strontium-89 in treating bone metastases.
PURPOSE: This randomized phase III trial is studying giving chemotherapy together with
strontium-89 to see how well it works compared to chemotherapy alone in treating patients
with prostate cancer that has spread to the bone.
Strontium Compared With Radiation Therapy in Treating Patients With Hormone-Refractory Prostate Cancer With Painful Bone Metastases [Active, not recruiting]
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and either kill them or
deliver tumor-killing substances to them without harming normal cells. This may be an
effective treatment for prostate cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of strontium or radiation
therapy in treating patients with prostate cancer that is refractory to hormone therapy who
have painful bone metastases.
Study of the Efficacy, Safety and Tolerability of Topical 2PX (Strontium Chloride Hexahydrate) in Patients With Chronic, Moderate-to-severe Lower Limb Post-amputation Stump Pain [Recruiting]
Primary: To compare the analgesic effect over 12 weeks of topical 2PX in stump pain.
Secondary: To prospectively measure other efficacy and safety variables of topical 2PX in
stump pain. Exploratory analyses will be performed to measure efficacy and safety variables
of topical 2PX in phantom pain
Reports of Suspected Metastron (Strontium Chloride, SR-89) Side Effects
Anaemia (20),
Disseminated Intravascular Coagulation (16),
Platelet Count Decreased (9),
Haemoglobin Decreased (6),
Interstitial Lung Disease (5),
Thrombocytopenia (5),
White Blood Cell Count Decreased (5),
Death (4),
Pancytopenia (4),
Septic Shock (3), more >>
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