Mesnex (Mesna) - Drug Interactions, Contraindications, Overdosage, etc

DRUG INTERACTIONS

Drug Interactions

No clinical drug studies have been conducted.

OVERDOSAGE

There is no known antidote for mesna. Oral doses of 6.1 and 4.3 g/kg were lethal to mice and rats, respectively. These doses are approximately 15 and 22 times the maximum recommended human dose on a body surface area basis. Death was preceded by diarrhea, tremor, convulsions, dyspnea, and cyanosis.

CONTRAINDICATIONS

Mesna is contraindicated in patients known to be hypersensitive to mesna or other thiol compounds.