Mesantoin® (mephenytoin) is 3-methyl 5,5-phenyl-ethyl-hydantoin. It may be considered to be the hydantoin homolog of the barbiturate mephobarbital.
Mesantoin (mephenytoin) is indicated for the following:
For the control of grand mal, focal, Jacksonian, and psychomotor seizures in those patients who have been refractory to less toxic anticonvulsants.
Published Studies Related to Mesantoin (Mephenytoin)
Identification of New CYP2C19 Variants Exhibiting Decreased Enzyme Activity in the Metabolism of S-Mephenytoin and Omeprazole. [2009.11]
Although many cases of interindividual variation in the metabolism of CYP2C19 drugs are explained by the CYP2C19*2, *3, and *17, a wide range of metabolic variation still occurs in people who do not carry these genetic variants. The objectives of this study were to identify new genetic variants and to characterize functional consequences of these variants in metabolism of CYP2C19 substrates...
Clinical Trials Related to Mesantoin (Mephenytoin)
Metabolic Capacity of Israeli Populations [Terminated]
The ability to metabolize drugs varies greatly among individuals. Major fraction of this
variability lies in genetic polymorphisms of genes encoding for enzymes responsible for both
phase I and phase II reactions.
The purpose of this study ws to evaluate the phenotypic activity and the frequency of
genetic polymorphisms in different phase II and phase I enzymes among various populations
residing in Israel.
Page last updated: 2009-10-20