MERIDIA SUMMARY
MERIDIA® (sibutramine hydrochloride monohydrate) is an orally administered agent for the treatment of obesity.
MERIDIA is indicated for the management of obesity, including weight loss and maintenance of weight loss, and should be used in conjunction with a reduced calorie diet. MERIDIA is recommended for obese patients with an initial body mass index >/=30 kg/m2, or >/=27 kg/m2 in the presence of other risk factors (e.g., hypertension, diabetes, dyslipidemia).
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MERIDIA NEWS HIGHLIGHTS Media Articles Related to Meridia (Sibutramine)
Synthroid and Meridia
Source: MedicineNet sibutramine Specialty [2006.11.14]
Title: Synthroid and Meridia
Category: Ask The Experts
Created: 1/29/2001 6:21:00 PM
Last Editorial Review: 11/14/2006
The Credit Crunch Blamed For Increase In Panic-Attacks, UK
Source: Anxiety / Stress News From Medical News Today [2009.06.16]
Members of The AMT (Association for Meridian & Energy Therapies) in the UK have noticed a dramatic increase in the number of clients attending therapy sessions because of anxiety, stress and in more severe cases, Panic Attacks. This has been directly related to the Credit Crunch and personal money worries.
Published Studies Related to Meridia (Sibutramine)
Tolerability of sibutramine during a 6-week treatment period in high-risk patients with cardiovascular disease and/or diabetes: a preliminary analysis of the Sibutramine Cardiovascular Outcomes (SCOUT) Trial. [2008.11]
Uncertainties about the cardiovascular safety of sibutramine [generic for Meridia] led to the SCOUT trial that is investigating sibutramine plus weight management in high-risk, overweight/obese patients. A 6-week lead-in period during which all patients received sibutramine permitted an initial assessment of tolerability... No new safety issues were detected.
A controlled pharmacogenetic trial of sibutramine on weight loss and body composition in obese or overweight adults. [2008.10]
BACKGROUND & AIMS: Weight loss in response to sibutramine [generic for Meridia] is highly variable. We assessed the association of specific markers of polymorphisms of candidate alpha2A adrenoreceptor, 5-HT transporter, and GNbeta3 genes and weight loss with sibutramine... CONCLUSIONS: Patient selection based on candidate genes may enhance response to multidimensional sibutramine and behavioral therapy for obesity.
Blood pressure changes associated with sibutramine and weight management - an analysis from the 6-week lead-in period of the sibutramine cardiovascular outcomes trial (SCOUT). [2008.07.29]
Objective: To explore vital sign changes among patient subgroups during the 6-week lead-in period of the sibutramine [generic for Meridia] cardiovascular outcomes (SCOUT) trial. Methods: SCOUT is an ongoing, double-blind, randomized, placebo-controlled outcome trial in overweight/obese patients at high risk of a cardiovascular event... Small pulse rate increases were observed regardless of blood pressure or weight change status.
Orlistat and sibutramine beyond weight loss. [2008.06]
BACKGROUND AND AIM: To investigate, through a meta-analysis of clinical trials, the effect of two weight-reducing drugs, such as orlistat and sibutramine [generic for Meridia], on serum lipid profiles in overweight and obese subjects, independently of weight loss... CONCLUSION: Orlistat or sibutramine, when individually compared to placebo, are effective in promoting significant weight loss. In addition, orlistat determines a significant reduction of total cholesterol, independent of weight loss itself. These observations indicate that orlistat is a useful adjunctive tool for improving cardiovascular risk factor profiles in overweight and obese patients.
Metformin plus sibutramine for olanzapine-associated weight gain and metabolic dysfunction in schizophrenia: a 12-week double-blind, placebo-controlled pilot study. [2008.05.30]
Metformin (850-1700 mg) plus sibutramine [generic for Meridia] (10-20 mg, n=13) or placebo (n=15) was administered for 12 weeks in olanzapine-treated chronic schizophrenia patients. Weight loss was similar in both groups: -2.8+/-3.2 kg vs.
Clinical Trials Related to Meridia (Sibutramine)
Weight Loss in Response to Sibutramine (MERIDIA) is Influenced by the Inherited Genes [Completed]
Control of food intake, size and frequency of meals are critical to the development of
obesity. The stomach signals feelings of fullness after a meal and therefore plays a role in
control of calorie intake. It is unclear whether the approved appetite reducing drug
sibutramine changes the function of the stomach. Differences in the way individuals respond
to treatment with the appetite suppressant sibutramine may also explain why some people lose
weight while others do not.
In a previous study of 48 overweight or obese participants, we preliminarily observed that
variation in the gene for the promoter of the serotonin transporter protein was significantly
associated with degree of weight loss.
This new single center clinical study aims to evaluate the effects of the FDA-approved
appetite suppressing medication, sibutramine (MERIDIA)on weight loss and stomach emptying in
patients who are overweight or obese. The effect of individual differences in inherited
genes that modify serrotonin and noradrenergic receptors on weight reduction with sibutramine
will be tested.
Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives [Completed]
To study the effect of sibutramine treatment on weight reduction and blood pressure
improvement in three groups with antihypertensive therapy whose blood pressure was not
adequately controlled with antihypertensive combination treatment.
Study to Examine the Longer-Term Efficacy and Safety of Sibutramine Hydrochloride in Obese Subjects [Terminated]
The study was designed to evaluate the long term efficacy and safety of Meridia 15 mg daily
in obese subjects.
Efficacy and Safety Study of Sibutramine in Overweight Non-Diabetic Malaysian Population [Completed]
The primary objective of this study was to evaluate the efficacy and the safety of
sibutramine vs. placebo in combination with a hypocaloric diet on weight-loss in overweight
and obese Malaysian subjects.
A Study to Examine the Efficacy and Safety of Meridia® (Sibutramine Hydrochloride) in Binge-Eating Disorder [Completed]
The purpose of this study is to examine the safety and efficacy of sibutramine in preventing
binge eating episodes. Additionally the study aim is to evaluate the safety and efficacy of
sibutramine in reducing body weight in subjects with binge-eating disorder.
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MERIDIA PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 4 ratings/reviews, Meridia has an overall score of 6.50. The effectiveness score is 6.50 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Meridia review by 26 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | Over eating, reduce wieght gain |
| Dosage & duration: | | 10mg taken once daily for the period of 3 months |
| Other conditions: | | high cholesterol, hypoglycemia |
| Other drugs taken: | | pantoprazole | | |
Reported Results |
| Benefits: | | Decreased meal size, felt more satisfied when I ate and felt fuller quicker. Didn't get hunger urges as often and started to loose weight as decreased my calorie intake |
| Side effects: | | Insomnia, headaches, nausea, increased heart rate |
| Comments: | | Reductil gave me a motivational start to healthy eating and decreasing my portion sizes. Because of low sugar levels I always feel hungry and it gave me some relief as I didnt get hungry as often and when I ate, I couldnt eat as much, but I felt satisfied. I felt that the effects of the drug started to ware off after a few months but now I dont take it anymore as I have lost about 5 kilos and want to continue to lose another 5 through healthy controlled eating and exercise. I feel I can control my eating a bit better and realised that the overeating was creating the roller coaster ride, so I think the drug helped me mentally with portion control and now I tell myself as I have created the habbit with better eating habbits. |
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| | Meridia review by 57 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | weight loss |
| Dosage & duration: | | 10 mg a day taken daily for the period of 2 mos |
| Other conditions: | | heartburn |
| Other drugs taken: | | prilosec | | |
Reported Results |
| Benefits: | | Definitely lifted mood. Helped me feel full and able to turn down unhealthy snacks. Helped me eat reasonable portions. |
| Side effects: | | Occasional headache. Mild occasional insomnia |
| Comments: | | Taken once a day it acts as a mood lifter and helps you feel full with less food. It helped me take off a few pounds. However, it is only a tool and patient has to be diligent about monitoring hunger and deciding to limit portions. It's easy to "eat around" the drug and overeat. For short term weight loss or to help lose 10 -15 lbs it is great. VERY expensive...$125 for one months supply. |
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| | Meridia review by 57 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | weight loss |
| Dosage & duration: | | 10 mg a day taken daily for the period of 2 mos |
| Other conditions: | | heartburn |
| Other drugs taken: | | prilosec | | |
Reported Results |
| Benefits: | | Definitely lifted mood. Helped me feel full and able to turn down unhealthy snacks. Helped me eat reasonable portions. |
| Side effects: | | Occasional headache. Mild occasional insomnia |
| Comments: | | Taken once a day it acts as a mood lifter and helps you feel full with less food. It helped me take off a few pounds. However, it is only a tool and patient has to be diligent about monitoring hunger and deciding to limit portions. It's easy to "eat around" the drug and overeat. For short term weight loss or to help lose 10 -15 lbs it is great. VERY expensive...$125 for one months supply. |
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Page last updated: 2009-06-16
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