MERIDIA SUMMARY
MERIDIA® (sibutramine hydrochloride monohydrate) is an orally administered agent for the treatment of obesity.
MERIDIA is indicated for the management of obesity, including weight loss and maintenance of weight loss, and should be used in conjunction with a reduced calorie diet. MERIDIA is recommended for obese patients with an initial body mass index >/=30 kg/m2, or >/=27 kg/m2 in the presence of other risk factors (e.g., hypertension, diabetes, dyslipidemia).
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NEWS HIGHLIGHTSMedia Articles Related to Meridia (Sibutramine)
FDA Panel Is Split on Ban of Diet Drug Meridia
Source: MedicineNet sibutramine Specialty [2010.09.16]
Title: FDA Panel Is Split on Ban of Diet Drug Meridia
Category: Health News
Created: 9/16/2010 6:00:00 AM
Last Editorial Review: 9/16/2010 12:00:00 AM
Weight Loss Pill Meridia Raises Heart Attack, Stroke Risks
Source: MedicineNet sibutramine Specialty [2010.09.02]
Title: Weight Loss Pill Meridia Raises Heart Attack, Stroke Risks
Category: Health News
Created: 9/2/2010 11:01:00 AM
Last Editorial Review: 9/2/2010 11:01:05 AM
Acupuncture Improves Memory, Test Performance, And Reduces Anxiety
Source: Complementary Medicine / Alternative Medicine News From Medical News Today [2013.03.09]
A new study shows that acupuncture improves memory, test performance, and reduces anxiety. The study will appear in an upcoming edition of The Journal of Acupuncture and Meridian Studies. Dr. Jason Bussell, PhD, conducted an experiment with 90 undergraduate students. Half the students received acupuncture and half did not; and the placebo effect was controlled...
Published Studies Related to Meridia (Sibutramine)
Systematic review of the clinical efficacy of sibutramine and orlistat in weigth loss, quality of life and its adverse effects in obese adolescents. [2011.06]
INTRODUCTION: The prevalence of obesity, a serious public health problem, is increasing among teenagers and thus also increases cardiovascular morbidity and mortality in adulthood. OBJECTIVE: To provide a systematic review of the best evidence about the effect of sibutramine and orlistat in weight loss, quality of life and its adverse effects in adolescents diagnosed with obesity... CONCLUSIONS: Sibutramine and orlistat in combination with a hypocaloric diet and changes in lifestyle in obese adolescents achieve a short-term loss of weight greater than that achieved through the dietary-behavioral therapy alone.
Effects of combination of sibutramine and L-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patients. [2011.03]
The aim of the study was to evaluate the effects of 12-month treatment with sibutramine plus L-carnitine compared with sibutramine alone on body weight, glycemic control, insulin resistance, and inflammatory state in type 2 diabetes mellitus patients... Sibutramine plus L-carnitine gave a better and faster improvement of all the analyzed parameters compared with sibutramine alone without giving any severe adverse effect.
Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum. [2010.10.27]
We used functional magnetic resonance imaging to explore brain responses to food images in overweight humans, examining independently the impact of a prescan meal ("satiety") and the anti-obesity drug sibutramine, a serotonin and noradrenaline reuptake inhibitor... Furthermore, they support a regionally specific effect on brain function through which sibutramine exerts its clinical effect.
Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. [2010.09.02]
BACKGROUND: The long-term effects of sibutramine treatment on the rates of cardiovascular events and cardiovascular death among subjects at high cardiovascular risk have not been established... CONCLUSIONS: Subjects with preexisting cardiovascular conditions who were receiving long-term sibutramine treatment had an increased risk of nonfatal myocardial infarction and nonfatal stroke but not of cardiovascular death or death from any cause. (Funded by Abbott; ClinicalTrials.gov number, NCT00234832.)
Enhanced weight loss following coadministration of pramlintide with sibutramine or phentermine in a multicenter trial. [2010.09]
Preclinical evidence suggests that pharmacotherapy for obesity using combinations of agents targeted at distinct regulatory pathways may produce robust additive or synergistic effects on weight loss. This randomized placebo-controlled trial examined the safety and efficacy of the amylin analogue pramlintide alone or in combination with either phentermine or sibutramine...
Clinical Trials Related to Meridia (Sibutramine)
Weight Loss in Response to Sibutramine (MERIDIA) is Influenced by the Inherited Genes [Completed]
Control of food intake, size and frequency of meals are critical to the development of
obesity. The stomach signals feelings of fullness after a meal and therefore plays a role in
control of calorie intake. It is unclear whether the approved appetite reducing drug
sibutramine changes the function of the stomach. Differences in the way individuals respond
to treatment with the appetite suppressant sibutramine may also explain why some people lose
weight while others do not.
In a previous study of 48 overweight or obese participants, we preliminarily observed that
variation in the gene for the promoter of the serotonin transporter protein was significantly
associated with degree of weight loss.
This new single center clinical study aims to evaluate the effects of the FDA-approved
appetite suppressing medication, sibutramine (MERIDIA)on weight loss and stomach emptying in
patients who are overweight or obese. The effect of individual differences in inherited
genes that modify serrotonin and noradrenergic receptors on weight reduction with sibutramine
will be tested.
Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives [Completed]
To study the effect of sibutramine treatment on weight reduction and blood pressure
improvement in three groups with antihypertensive therapy whose blood pressure was not
adequately controlled with antihypertensive combination treatment.
Study to Examine the Longer-Term Efficacy and Safety of Sibutramine Hydrochloride in Obese Subjects [Terminated]
The study was designed to evaluate the long term efficacy and safety of Meridia 15 mg daily
in obese subjects.
Efficacy and Safety Study of Sibutramine in Overweight Non-Diabetic Malaysian Population [Completed]
The primary objective of this study was to evaluate the efficacy and the safety of
sibutramine vs. placebo in combination with a hypocaloric diet on weight-loss in overweight
and obese Malaysian subjects.
A Study to Examine the Efficacy and Safety of Meridia® (Sibutramine Hydrochloride) in Binge-Eating Disorder [Completed]
The purpose of this study is to examine the safety and efficacy of sibutramine in preventing
binge eating episodes. Additionally the study aim is to evaluate the safety and efficacy of
sibutramine in reducing body weight in subjects with binge-eating disorder.
Reports of Suspected Meridia (Sibutramine) Side Effects
Aphasia (2),
Hemiparesis (2),
Cerebrovascular Accident (2),
Disability (2),
Drug Ineffective (1),
Foetal Exposure During Pregnancy (1),
Impaired Work Ability (1),
Pain (1),
Paralysis (1),
Pulmonary Embolism (1), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 17 ratings/reviews, Meridia has an overall score of 8.53. The effectiveness score is 8.71 and the side effect score is 7.88. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Meridia review by 21 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Overeating, weight gain |
| Dosage & duration: | | 15mg taken once daily (best in the morning) for the period of 7 months |
| Other conditions: | | Insomnia, dry mouth, mild headaches |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | I lost 90 pounds in 6 months. The key was drinking water all throughout the day. I ate 1 meal a day before 6pm & snacked on fruit (applesauce, fruit cups, canned fruit,etc.) all through the day (instead of fast food, icecream, chips or any other food that is unhealthy). I saw no results in the first month, but once 30 days had passed, I started to lose 1 lb. a day & sometimes 1 1'2 lb. a day. Even after getting off of Meridia, I still continued to lose weight 2 months later. Product was VERY expensive but worth it! The more weight you have to lose the more you WILL lose! |
| Side effects: | | Insomnia sometimes. My bedtime(before Meridia) was around 10pm but once I began taking the medicine, I couldn't sleep sometimes until 12am or 1am, but even with lack of sleep, I never felt fatigued like I thought I would. Every once in a while, mild headaches & dry mouth. But nothing too major or life-threatening. |
| Comments: | | Lost 91 lbs. in 6-7 months. Kept the weight off even to this day (4 years later) b/c the Meridia taught me the key to weight loss: Less calorie intake. And since the Meridia trained my body to get full quicker, I was able to still eat & crave less even after getting off of the medication. |
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| | Meridia review by 26 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | Over eating, reduce wieght gain |
| Dosage & duration: | | 10mg taken once daily for the period of 3 months |
| Other conditions: | | high cholesterol, hypoglycemia |
| Other drugs taken: | | pantoprazole | | |
Reported Results |
| Benefits: | | Decreased meal size, felt more satisfied when I ate and felt fuller quicker. Didn't get hunger urges as often and started to loose weight as decreased my calorie intake |
| Side effects: | | Insomnia, headaches, nausea, increased heart rate |
| Comments: | | Reductil gave me a motivational start to healthy eating and decreasing my portion sizes. Because of low sugar levels I always feel hungry and it gave me some relief as I didnt get hungry as often and when I ate, I couldnt eat as much, but I felt satisfied. I felt that the effects of the drug started to ware off after a few months but now I dont take it anymore as I have lost about 5 kilos and want to continue to lose another 5 through healthy controlled eating and exercise. I feel I can control my eating a bit better and realised that the overeating was creating the roller coaster ride, so I think the drug helped me mentally with portion control and now I tell myself as I have created the habbit with better eating habbits. |
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| | Meridia review by 57 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | weight loss |
| Dosage & duration: | | 10 mg a day taken daily for the period of 2 mos |
| Other conditions: | | heartburn |
| Other drugs taken: | | prilosec | | |
Reported Results |
| Benefits: | | Definitely lifted mood. Helped me feel full and able to turn down unhealthy snacks. Helped me eat reasonable portions. |
| Side effects: | | Occasional headache. Mild occasional insomnia |
| Comments: | | Taken once a day it acts as a mood lifter and helps you feel full with less food. It helped me take off a few pounds. However, it is only a tool and patient has to be diligent about monitoring hunger and deciding to limit portions. It's easy to "eat around" the drug and overeat. For short term weight loss or to help lose 10 -15 lbs it is great. VERY expensive...$125 for one months supply. |
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Page last updated: 2013-03-09
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