ADVERSE REACTIONS
Central Nervous System
Drowsiness, ataxia, dizziness, slurred speech, headache, vertigo, weakness, paresthesias, impairment of visual accommodation, euphoria, overstimulation, paradoxical excitement, fast EEG activity.
Gastrointestinal
Nausea, vomiting, diarrhea.
Cardiovascular
Palpitation, tachycardia, various forms of arrhythmia, transient ECG changes, syncope; also hypotensive crisis (including one fatal case).
Allergic or Idiosyncratic
Allergic or idiosyncratic reactions are usually seen within the period of the first to fourth dose in patients having had no previous contact with the drug. Milder reactions are characterized by an itchy, urticarial, or erythematous maculopapular rash which may be generalized or confined to the groin. Other reactions have included leukopenia, acute nonthrombocytopenic purpura, petechiae, ecchymoses, eosinophilia, peripheral edema, adenopathy, fever, fixed drug eruption with cross reaction to carisoprodol, and cross sensitivity between meprobamate/mebutamate and meprobamate/carbromal.
More severe hypersensitivity reactions, rarely reported, include hyperpyrexia, chills, angioneurotic edema, bronchospasm, oliguria and anuria. Also, anaphylaxis, erythema multiforme, exfoliative dermatitis, stomatitis, proctitis, Stevens-Johnson syndrome and bullous dermatitis, including one fatal case of the latter following administration of meprobamate in combination with prednisolone.
In case of allergic or idiosyncratic reactions to meprobamate, discontinue the drug and initiate appropriate symptomatic therapy, which may include epinephrine, antihistamines, and in severe cases, corticosteroids. In evaluating possible allergic reactions, also consider allergy to excipients.
Hematologic
(See also Allergic or Idiosyncratic .) Agranulocytosis and aplastic anemia have been reported. These cases rarely were fatal. Rare cases of thrombocytopenic purpura have been reported.
Other
Exacerbation of porphyric symptoms.
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REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO MEPROBAMATE
Below is a sample of reports where side effects / adverse reactions may be related to Meprobamate. The information is not vetted and should not be cosidered as verified clinical evidence.
Possible Meprobamate side effects / adverse reactions in 57 year old female
Reported by a individual with unspecified qualification from France on 2007-01-26
Patient: 57 year old female
Reactions: Pneumonia Aspiration, Hypotension, Coma, Life Support, Multiple Drug Overdose
Adverse event resulted in: hospitalization
Suspect drug(s):
Effexor
Dosage: overdose amount 1500 mg
Start date: 1999-01-01
End date: 1999-01-01
Meprobamate
Dosage: overdose amount ^1200^
Start date: 1999-01-01
End date: 1999-01-01
Possible Meprobamate side effects / adverse reactions in 71 year old female
Reported by a individual with unspecified qualification from United States on 2007-05-10
Patient: 71 year old female weighing 59.0 kg (129.7 pounds)
Reactions: Depressed Level of Consciousness, Fall, Cerebral Haemorrhage
Adverse event resulted in: death, life threatening event, hospitalization
Suspect drug(s):
Meprobamate
Possible Meprobamate side effects / adverse reactions in 48 year old female
Reported by a physician from United States on 2007-06-11
Patient: 48 year old female weighing 108.4 kg (238.5 pounds)
Reactions: Malaise, Accidental Overdose, Pallor
Adverse event resulted in: death
Suspect drug(s):
Oxycontin
Dosage: 40 mg, oral
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
Roxicodone
Indication: Drug USE FOR Unknown Indication
Opioids
Dosage: see text
Indication: Drug USE FOR Unknown Indication
Hydrocodone (Hydrocodone)
Dosage: see text
Indication: Drug USE FOR Unknown Indication
Carisoprodol (Carisoprodol)
Dosage: see text
Indication: Drug USE FOR Unknown Indication
Meprobamate
Dosage: see text
Indication: Drug USE FOR Unknown Indication
Diphenhydramine HCL
Dosage: see text
Indication: Drug USE FOR Unknown Indication
Caffeine Citrate
Dosage: see text
Indication: Drug USE FOR Unknown Indication
Nicotine
Dosage: see text
Indication: Smoker
Benzodiazepine Derivatives
Dosage: see tex
Indication: Drug USE FOR Unknown Indication
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