DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Meprobamate (Meprobamate) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Central Nervous System

Drowsiness, ataxia, dizziness, slurred speech, headache, vertigo, weakness, paresthesias, impairment of visual accommodation, euphoria, overstimulation, paradoxical excitement, fast EEG activity.

Gastrointestinal

Nausea, vomiting, diarrhea.

Cardiovascular

Palpitation, tachycardia, various forms of arrhythmia, transient ECG changes, syncope; also hypotensive crisis (including one fatal case).

Allergic or Idiosyncratic

Allergic or idiosyncratic reactions are usually seen within the period of the first to fourth dose in patients having had no previous contact with the drug. Milder reactions are characterized by an itchy, urticarial, or erythematous maculopapular rash which may be generalized or confined to the groin. Other reactions have included leukopenia, acute nonthrombocytopenic purpura, petechiae, ecchymoses, eosinophilia, peripheral edema, adenopathy, fever, fixed drug eruption with cross reaction to carisoprodol, and cross sensitivity between meprobamate/mebutamate and meprobamate/carbromal.

More severe hypersensitivity reactions, rarely reported, include hyperpyrexia, chills, angioneurotic edema, bronchospasm, oliguria and anuria. Also, anaphylaxis, erythema multiforme, exfoliative dermatitis, stomatitis, proctitis, Stevens-Johnson syndrome and bullous dermatitis, including one fatal case of the latter following administration of meprobamate in combination with prednisolone.

In case of allergic or idiosyncratic reactions to meprobamate, discontinue the drug and initiate appropriate symptomatic therapy, which may include epinephrine, antihistamines, and in severe cases, corticosteroids. In evaluating possible allergic reactions, also consider allergy to excipients.

Hematologic

(See also Allergic or Idiosyncratic.) Agranulocytosis and aplastic anemia have been reported. These cases rarely were fatal. Rare cases of thrombocytopenic purpura have been reported.

Other

Exacerbation of porphyric symptoms.



REPORTS OF SUSPECTED MEPROBAMATE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Meprobamate. The information is not vetted and should not be considered as verified clinical evidence.

Possible Meprobamate side effects / adverse reactions in 41 year old male

Reported by a individual with unspecified qualification from United States on 2011-10-07

Patient: 41 year old male weighing 108.0 kg (237.5 pounds)

Reactions: Cholesterosis, Sudden Death, Hepatic Steatosis, Visceral Congestion, Aspiration, Pulmonary Congestion, Coronary Ostial Stenosis, Pulmonary Oedema, Brain Oedema, Multiple Drug Overdose

Adverse event resulted in: death

Suspect drug(s):
Methadone HCL
    Indication: Back Disorder

Meprobamate
    Indication: Back Disorder

Opana
    Indication: Back Disorder

Carisoprodol
    Indication: Back Disorder

Fentanyl
    Indication: Back Disorder



Possible Meprobamate side effects / adverse reactions in 25 year old male

Reported by a physician from United States on 2011-10-12

Patient: 25 year old male

Reactions: Multiple Drug Overdose Accidental

Adverse event resulted in: death

Suspect drug(s):
Carisoprodol

Alprazolam

Methadone HCL

Meprobamate



Possible Meprobamate side effects / adverse reactions in 27 year old female

Reported by a physician from United States on 2011-10-24

Patient: 27 year old female weighing 58.5 kg (128.7 pounds)

Reactions: Contusion, Hepatic Necrosis, Pulmonary Congestion, Accidental Death, Pulmonary Oedema, Toxicity TO Various Agents

Adverse event resulted in: death

Suspect drug(s):
Carisoprodol
    Indication: Product Used FOR Unknown Indication

Meprobamate
    Indication: Product Used FOR Unknown Indication

Benzodiazepines (Unknown)
    Indication: Product Used FOR Unknown Indication

Xyrem
    Dosage: 5 gm (2.5 gm, 2 in 1 d), oral; 13.5 gm (6.75 gm, 2 in 1 d), oral
    Administration route: Oral
    Indication: Insomnia
    Start date: 2011-05-10
    End date: 2011-07-01

Xyrem
    Dosage: 5 gm (2.5 gm, 2 in 1 d), oral; 13.5 gm (6.75 gm, 2 in 1 d), oral
    Administration route: Oral
    Indication: Insomnia
    Start date: 2005-11-10

Nicotine
    Indication: Product Used FOR Unknown Indication

Ibuprofen
    Indication: Product Used FOR Unknown Indication

Chlordiazepoxide
    Indication: Product Used FOR Unknown Indication

Nordiazepam (Unknown)
    Indication: Product Used FOR Unknown Indication

Opiates (Unknown)
    Indication: Product Used FOR Unknown Indication

Acetaminophen
    Indication: Product Used FOR Unknown Indication

Oxazepam
    Indication: Product Used FOR Unknown Indication



See index of all Meprobamate side effect reports >>

Drug label data at the top of this Page last updated: 2011-07-19

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017