Mephyton (Phytonadione) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

Drug Interactions

Temporary resistance to prothrombin-depressing anticoagulants may result, especially when larger doses of phytonadione are used. If relatively large doses have been employed, it may be necessary when reinstituting anticoagulant therapy to use somewhat larger doses of the prothrombin-depressing anticoagulant, or to use one which acts on a different principle, such as heparin sodium.

OVERDOSAGE

The intravenous and oral LD₅₀s in the mouse are approximately 1.17 g/kg and greater than 24.18 g/kg, respectively.

CONTRAINDICATIONS

Hypersensitivity to any component of this medication.