DOSAGE AND ADMINISTRATION
MEPHYTON
Summary of Dosage Guidelines
(See circular text for details) |
| Adults | Initial Dosage |
Anticoagulant-Induced
Prothrombin Deficiency
(caused by coumarin or indanedione derivatives) | 2.5 mg-10 mg or up to
25 mg (rarely 50 mg) |
Hypoprothrombinemia due
to other causes
(Antibiotics; Salicylates or other drugs;
Factors limiting absorption or synthesis) | 2.5 mg-25 mg or more
(rarely up to 50 mg) |
Anticoagulant-Induced Prothrombin Deficiency in Adults
To correct excessively prolonged prothrombin times caused by oral anticoagulant therapy— 2.5 to 10 mg or up to 25 mg initially is recommended. In rare instances 50 mg may be required. Frequency and amount of subsequent doses should be determined by prothrombin time response or clinical condition. (See WARNINGS.) If, in 12 to 48 hours after oral administration, the prothrombin time has not been shortened satisfactorily, the dose should be repeated.
Hypoprothrombinemia Due to Other Causes in Adults
If possible, discontinuation or reduction of the dosage of drugs interfering with coagulation mechanisms (such as salicylates, antibiotics) is suggested as an alternative to administering concurrent MEPHYTON. The severity of the coagulation disorder should determine whether the immediate administration of MEPHYTON is required in addition to discontinuation or reduction of interfering drugs.
A dosage of 2.5 to 25 mg or more (rarely up to 50 mg) is recommended, the amount and route of administration depending upon the severity of the condition and response obtained.
The oral route should be avoided when the clinical disorder would prevent proper absorption. Bile salts must be given with the tablets when the endogenous supply of bile to the gastrointestinal tract is deficient.
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