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Mephyton (Phytonadione) - Summary

 

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MEPHYTON SUMMARY


MEPHYTON®
(PHYTONADIONE)
TABLETS
Vitamin K1

MEPHYTON tablets possess the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).

MEPHYTON is indicated in the following coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity.

MEPHYTON tablets are indicated in:

  • anticoagulant-induced prothrombin deficiency caused by coumarin or indanedione derivatives;
  • hypoprothrombinemia secondary to antibacterial therapy;
  • hypoprothrombinemia secondary to administration of salicylates;
  • hypoprothrombinemia secondary to obstructive jaundice or biliary fistulas but only if bile salts are administered concurrently, since otherwise the oral vitamin K will not be absorbed.

MEPHYTON NEWS HIGHLIGHTS

Published Studies Related to Mephyton (Phytonadione)

Comparison of oral vs intravenous phytonadione (vitamin K1) in patients with excessive anticoagulation: a prospective randomized controlled study. [2003.11.10]

Randomized, placebo-controlled trial of oral phytonadione for excessive anticoagulation. [2000.10]

Time course of reversal of anticoagulant effect of warfarin by intravenous and subcutaneous phytonadione. [1999.12.13]

Reversal of excessive effect of regular anticoagulation: low oral dose of phytonadione (vitamin K1) compared with warfarin discontinuation. [1993.10]

Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. [2006.02.27]

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Clinical Trials Related to Mephyton (Phytonadione)

Vitamin K Supplementation in Post-Menopausal Osteopenia [Active, not recruiting]

Oral Vitamin K for Warfarin Associated Coagulopathy [Active, not recruiting]

Vitamin K and Bone Turnover in Postmenopausal Women [Completed]

Determinants of Vitamin K Metabolism [Recruiting]

Investigation of the Effect of BONISTEIN(R) Bone Blend on Bone Mineral Density/Content and Biomarkers of Bone Health [Active, not recruiting]

more>>

Page last updated: 2006-11-04

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