Meperidine (Meperidine Hydrochloride) - Summary

MEPERIDINE SUMMARY

MEPERIDINE HYDROCHLORIDE
TABLETS, USP
Rx Only

Meperidine Hydrochloride Injection, USP 10 mg/mL is a sterile, nonpyrogenic, hypotonic solution of meperidine hydrochloride, USP, in an acetate buffer. This product is to be administered by the intravenous route via a compatible Hospira infusion device. Each mL contains meperidine hydrochloride 10 mg. Sodium acetate, anhydrous 1.5 mg and glacial acetic acid, 0.0012 mL are added as buffers. pH 4.5 (3.5 to 6.0). The solution contains no bacteriostat or antimicrobial agent and is intended only for use as a single-dose unit to provide analgesia via the intravenous route using a compatible Hospira infusion device. Meperidine is classified pharmacologically as a synthetic narcotic analgesic. Meperidine Hydrochloride is ethyl-1-methyl-4-phenylisonipecotate hydrochloride, a white, crystalline substance with a melting point of 186° to 189°C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling.

Meperidine hydrochloride administered by slow intravenous injection is indicated for the relief of moderate to severe pain.

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NEWS HIGHLIGHTS

Published Studies Related to Meperidine

Perineural meperidine blocks nerve conduction in a dose-related manner: a randomized double-blind study. [2009.07]
BACKGROUND: Meperidine has been shown to exhibit a sensory block in peripheral nerves. However, its motor blockade ability is controversial...

Remifentanil vs. meperidine for patient-controlled analgesia during colonoscopy: a randomized double-blind trial. [2009.05]
OBJECTIVES: The aim was to compare patients' and endoscopists' satisfaction in terms of efficacy and safety of remifentanil patient-controlled analgesia (PCA) during colonoscopy with that of a combination of midazolam and meperidine... CONCLUSIONS: Remifentanil PCA is safe and effective to induce sedoanalgesia during colonoscopy. Further studies should address the optimization of dosing and lock out setting.

Clinical trial: a randomized, study comparing meperidine (pethidine) and fentanyl in adult gastrointestinal endoscopy. [2009.04.15]
BACKGROUND: There is little evidence to guide choice between meperidine (pethidine) and fentanyl for sedation for gastrointestinal endoscopy. AIM: To compare meperidine with fentanyl in terms of procedure time and analgesia... CONCLUSIONS: Fentanyl shortened total procedure time by reducing recovery time. A simple change in narcotic choice could increase endoscopy unit efficiency.

Midazolam with meperidine or fentanyl for colonoscopy: results of a randomized trial. [2009.03]
BACKGROUND: A combination of midazolam and opioid is usually used to achieve sedation and analgesia during colonoscopy. Two commonly used opioids are meperidine and fentanyl, but few studies have compared their efficacy. OBJECTIVE: This randomized trial aimed to compare the efficacy and recovery time of 2 sedation regimens consisting of midazolam in combination with either meperidine or fentanyl... CONCLUSIONS: The use of fentanyl in combination with low-dose midazolam results in significantly faster recovery from sedation compared with meperidine, without any apparent loss of analgesic effect.

Clinical trial: a randomized, study comparing fentanyl and meperidine in adult gastrointestinal endoscopy. [2009.01.20]
Background: There is little evidence to guide choice between meperidine and fentanyl for sedation for gastrointestinal endoscopy Aim: To compare meperidine to fentanyl in terms of procedure time and analgesia...

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Clinical Trials Related to Meperidine

Neuraxial Pethidine After Lumbar Surgery Trial [Recruiting]
The hypothesis is that epidural pethidine is an effective form of pain relief following lumbar spinal surgery, resulting in significantly lower usage of concomitantly administered (intravenous) patient-controlled analgesia (PCA) pethidine.

Comparison Between Nurse-Administered Propofol Sedation and Diazemuls / Pethidine in Outpatient Colonoscopy [Completed]
Colonoscopy is a common endoscopic procedure as an investigation of colorectal pathology. Different modalities of pain control have been described in the past. Propofol is a perfect drug for endoscopic procedure since it has the characteristic of fast onset, short half-life and early recovery. Its unfamiliarity and its potential cardiovascular and respiratory side effect make it unpopular to endoscopists. Recent reports showed propofol is safe in bolus titration by nurse in Caucasian in all endoscopic procedures. Our previous pilot study showed nurse administered propofol sedation (NAPS) is effective and safe and highly acceptable by Chinese patients. Here we conduct a randomized controlled study to compare the effectiveness of NAPS versus traditional sedation.

Epidural Analgesia Versus IV Meperidine for Labor Pain Control [Completed]
60 female that care for pain control during second stage of delivery, will choose between epidural or systemic analgesia. Continuous ECG (3 lead)monitoring will be recorded during the second stage for 10 minutes. 30 minutes after administration of either pain relief, a second recording of maternal ECG will take place for 10 minutes.

Adjunct Sedatives in Procedures Involving Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP) [Recruiting]
The purpose of this study is to compare meperidine/midazolam with diphenhydramine, meperidine/midazolam with promethazine, and meperidine/midazolam with placebo as sedation methods. The investigators are interested to see whether adjunct sedatives (diphenhydramine and promethazine) will improve sedation.

Sedation and Analgesia for Transjugular Liver Biopsy: A Randomized Double Blind Placebo Controlled Trial [Completed]
Transjugular liver catheterisation allows the measurement of hepatic venous pressure gradient (HVPG) and the sampling of liver tissue but patient's tolerance to the procedure is unknown. The aim of this study was to assess tolerance to transjugular hepatic liver biopsy with or without conscious sedation/analgesia.

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PATIENT REVIEWS / RATINGS / COMMENTS

Meperidine review by 31 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		painkiller after surgery
Dosage & duration:		50mg taken every 4 hours for the period of 1 week
Other conditions:		none
Other drugs taken:		antibiotics
		Reported Results
Benefits:		it was a very strong pain killer.
Side effects:		extreme disorientation.
Comments:		even though it was a very strong pain killer there was still considerable pain felt before the next prescribed dose was to be taken. i don't know if the anti nausea ingredient was effective because i felt like vomiting every time i smelled food and did vomit whenever i tried to eat, for about 3 days. however, i didn't feel nauseous when there was no food present. i was too disoriented to perform daily functions without help, or think clearly while using the prescription. after i stopped taking the pills it took a day or two before this effect wore off.