OVERDOSAGE
Symptoms and Signs
In cases of overdosage with mefloquine, the symptoms mentioned
under
ADVERSE
REACTIONS
may be more pronounced.
Treatment
Patients should be managed by symptomatic and supportive care
following mefloquine overdose. There are no specific antidotes. Monitor cardiac
function (if possible by ECG) and neuropsychiatric status for at least 24 hours.
Provide symptomatic and intensive supportive treatment as required, particularly
for cardiovascular disturbances.
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CONTRAINDICATIONS
Use of mefloquine hydrochloride tablets is contraindicated in patients with a
known hypersensitivity to mefloquine or related compounds (eg, quinine and
quinidine) or to any of the excipients contained in the formulation. Mefloquine
hydrochloride tablets should not be prescribed for prophylaxis in patients with
active depression, a recent history of depression, generalized anxiety disorder,
psychosis, or schizophrenia or other major psychiatric disorders, or with a
history of convulsions.
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