ADVERSE REACTIONS
Side effects observed in association with the use of MAXZIDE, other combination products containing triamterene/hydrochlorothiazide, and products containing triamterene or hydrochlorothiazide include the following:
Gastrointestinal: jaundice (intrahepatic cholestatic jaundice), pancreatitis, nausea, appetite disturbance, taste alteration, vomiting, diarrhea, constipation, anorexia, gastric irritation, cramping.
Central Nervous System: drowsiness and fatigue, insomnia, headache, dizziness, dry mouth, depression, anxiety, vertigo, restlessness, paresthesias.
Cardiovascular: tachycardia, shortness of breath and chest pain, orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics).
Renal: acute renal failure, acute interstitial nephritis, renal stones composed of triamterene in association with other calculus materials, urine discoloration.
Hematologic: leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia and megaloblastosis.
Ophthalmic: xanthopsia, transient blurred vision.
Hypersensitivity: anaphylaxis, photosensitivity, rash, urticaria, purpura, necrotizing angiitis (vasculitis, cutaneous vasculitis), fever, respiratory distress including pneumonitis.
Other: muscle cramps and weakness, decreased sexual performance and sialadenitis.
Whenever adverse reactions are moderate to severe, therapy should be reduced or withdrawn.
Altered Laboratory Findings:
Serum Electrolytes: hyperkalemia, hypokalemia, hyponatremia, hypomagnesemia, hypochloremia (see WARNINGS, PRECAUTIONS).
Creatinine, Blood Urea Nitrogen: Reversible elevations in BUN and serum creatinine have been observed in hypertensive patients treated with MAXZIDE.
Glucose: hyperglycemia, glycosuria and diabetes mellitus (see PRECAUTIONS).
Serum Uric Acid, PBI and Calcium: (see PRECAUTIONS).
Other: Elevated liver enzymes have been reported in patients receiving MAXZIDE.
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REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO MAXZIDE
Below is a sample of reports where side effects / adverse reactions may be related to Maxzide. The information is not vetted and should not be cosidered as verified clinical evidence.
Possible Maxzide side effects / adverse reactions in 58 year old female
Reported by a pharmacist from United States on 2007-01-22
Patient: 58 year old female
Reactions: Drug Ineffective, Hypercalcaemia
Suspect drug(s):
Maxzide
Other drugs received by patient: Docusate NA; Lansoprazole; Phenazopyridine HCL TAB; Humibid SR; Estrogens Sol/inj
Possible Maxzide side effects / adverse reactions in 86 year old female
Reported by a consumer/non-health professional from United States on 2007-02-26
Patient: 86 year old female weighing 38.5 kg (84.7 pounds)
Reactions: Asthma, HIP Arthroplasty, Dementia, Clostridium Colitis, Fall, Suicidal Ideation, Suicide Attempt, Pulmonary Oedema, Depression, Kidney Infection
Adverse event resulted in: hospitalization
Suspect drug(s):
Maxzide
Dosage: oral
Administration route: Oral
Start date: 1999-01-01
End date: 2006-12-20
Mirtazapine
Dosage: 30 mg, qhs; oral; 30 mg qhs; oral
Administration route: Oral
Indication: Depression
Start date: 2006-06-01
End date: 2006-12-20
Mirtazapine
Dosage: 30 mg, qhs; oral; 30 mg qhs; oral
Administration route: Oral
Indication: Depression
Start date: 2007-02-08
End date: 2007-02-11
Other drugs received by patient: Namenda; Albuterol; Aricept
Possible Maxzide side effects / adverse reactions in 56 year old female
Reported by a lawyer from United States on 2007-03-02
Patient: 56 year old female weighing 68.0 kg (149.7 pounds)
Reactions: Heart Rate Decreased, Blood Potassium Decreased, Pharmaceutical Product Complaint, Loss of Consciousness
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Maxzide
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