MAXIDEX SUMMARY
MAXIDEX® 0.1% (dexamethasone ophthalmic suspension) is an adrenocortical steroid prepared as a sterile topical ophthalmic suspension.
Maxidex (dexamethasone OPHTHALMIC) is indicated for the following:
Steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctuate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitides when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation; corneal injury from chemical, radiation, or thermal burns, or penetration of foreign bodies.
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NEWS HIGHLIGHTS
Published Studies Related to Maxidex (Dexamethasone Ophthalmic)
Phase 2 trial results with the novel neurokinin-1 receptor antagonist casopitant in combination with ondansetron and dexamethasone for the prevention of chemotherapy-induced nausea and vomiting in cancer patients receiving moderately emetogenic chemotherapy. [2009.10.15]
BACKGROUND:: This randomized, double-blind, dose-ranging, placebo-controlled, phase 2 trial evaluated the neurokinin-1 receptor antagonist casopitant mesylate in combination with ondansetron/dexamethasone (ond/dex) for the prevention of chemotherapy-induced nausea and vomiting (CINV) related to moderately emetogenic chemotherapy (MEC)... CONCLUSIONS:: Casopitant plus ond/dex was more effective than ond/dex alone for the prevention of CINV. Cancer 2009. (c) 2009 American Cancer Society.
Dexamethasone decreases oxycodone consumption following osteotomy of the first metatarsal bone: a randomized controlled trial in day surgery. [2009.10.10]
Background: Dexamethasone may improve multimodal pain management following painful orthopedic day surgery procedures, and decrease the need for post-operative opioids. We hypothesized that dexamethasone would reduce the need for oxycodone after surgical correction of hallux valgus... Conclusion: Oral dexamethasone combined with paracetamol significantly reduced total oxycodone consumption following surgical correction of hallux valgus.
Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations and clinical outcomes in tuberculous meningitis. [2009.09.30]
BACKGROUND: Adjunctive dexamethasone reduces mortality from tuberculous meningitis, but how it produces this effect is not known. Matrix metalloproteinases (MMPs) are important in the immunopathology of many inflammatory CNS diseases thus we hypothesized that that their secretion is important in TBM and might be influenced by dexamethasone...
l-Epinephrine and dexamethasone in postextubation airway obstruction: A prospective, randomized, double-blind placebo-controlled study. [2009.09.15]
CONCLUSIONS: Dexamethasone and l-epinephrine did not reduce the clinical progression of airway obstruction due to laryngeal edema in the early postextubation period.
An Open Randomized Controlled Trial of Desmopressin, and Pulse Dexamethasone as Adjunctive Therapy in Patients with Pulmonary Involvement Associated with Severe Leptospirosis. [2009.09.02]
Abstract Pulmonary involvement in leptospirosis is emerging as a common complication associated with severe leptospirosis. A prospective randomized controlled trial of desmopressin or high dose (pulse) dexamethasone as adjunctive therapy in 68 patients with pulmonary involvement associated with severe leptospirosis was conducted between July 2003 and October 2006 at 5 hospitals in Thailand...
Clinical Trials Related to Maxidex (Dexamethasone Ophthalmic)
Dexamethasone for Paediatric Adeno-Tonsillectomy - A Dose-Finding Study [Terminated]
Adeno-tonsillectomy is a commonly performed surgical procedure in children. Main morbidities
are postoperative pain, nausea and vomiting, and haemorrhage. Non-steroidal anti-inflammatory
drugs (NSAIDs)widely used for paincontrol increase the risk of postoperative bleeding and
reoperation. Dexamethasone is an powerful antiemetic and has shown analgesic efficacy.
Antiemetic and analgesic dose-response has never been established.
XERECEPT® (hCRF) for Patients Requiring Dexamethasone to Treat Edema Associated With Brain Tumors [Completed]
The purpose of this study is to compare the safety and efficacy of XERECEPT® to dexamethasone
(Decadron) a common treatment for symptoms of brain swelling (edema). This study is
specifically aimed at patients who require chronic high doses of dexamethasone to manage
symptoms.
Vincristine, DOXIL® (Doxorubicin HCl Liposome Injection) and Dexamethasone vs. Vincristine, Doxorubicin, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma [Completed]
The purpose of this study is to determine how well newly diagnosed multiple myeloma patients
respond to an experimental regimen of Vincristine, DOXIL (doxorubicin HCl liposome injection)
and Dexamethasone (VDD) versus the standard treatment of Vincristine, Doxorubicin and
Dexamethasone (VAD).
Dexamethasone or Dexamethasone in Combination With Thalidomide as Salvage Therapy [Completed]
The purpose of this investigational trial is to find out how well patients respond and how
long their response lasts when treated with a standard regimen of dexamethasone with or
without thalidomide and also find out what kind of side effects patients will experience.
Thalidomide + Dexamethasone vs. DOXIL (Doxorubicin HCl Liposome Injection) + Thalidomide + Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma [Active, not recruiting]
The main purpose of this study is to determine if Thalidomide + Dexamethasone or DOXIL
(doxorubicin HCl liposome injection) + Thalidomide + Dexamethasone is more effective in
treating patients newly diagnosed with multiple myeloma. The number of patients whose
multiple myeloma disappears for a period of time (also called "Complete Response") will be
studied to make the determination of which treatment is more effective.
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