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Maxalt-Mlt (Rizatriptan Benzoate) - Summary



MAXALT contains rizatriptan benzoate, a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist.

MAXALT is indicated for the acute treatment of migraine attacks with or without aura in adults.

MAXALT is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine (see CONTRAINDICATIONS). Safety and effectiveness of MAXALT have not been established for cluster headache, which is present in an older, predominantly male population.

See all Maxalt-Mlt indications & dosage >>


Media Articles Related to Maxalt-Mlt (Rizatriptan)

Psoriasis and Migraine: What's the Connection?
Source: Medscape Allergy & Clinical Immunology Headlines [2015.11.25]
A disease severity-dependent increased risk for migraine in psoriasis and increased risk for new-onset migraine in psoriatic arthritis could be mediated by the usual suspects--proinflammatory cytokines.
Medscape Dermatology

Precision injections of Botox into migraine "centres"
Source: Headache / Migraine News From Medical News Today [2015.10.12]
Researchers are using a high-precision instrument to inject toxins that alleviate migraine attacks. This means even better needle guidance and user-friendliness.

Scientists discover potential biomarker for migraine in the blood
Source: Headache / Migraine News From Medical News Today [2015.09.10]
Researchers may have found a biomarker for episodic migraine in the blood, a discovery that could have implications for the diagnosis and treatment of the condition.

Balance Disorders Pictures Slideshow: Vertigo, Migraines, Motion Sickness and More
Source: MedicineNet Vestibular Balance Disorders Specialty [2015.08.18]
Title: Balance Disorders Pictures Slideshow: Vertigo, Migraines, Motion Sickness and More
Category: Slideshows
Created: 3/6/2012 12:00:00 AM
Last Editorial Review: 8/18/2015 12:00:00 AM

Can migraine increase your risk of stroke?
Source: Headache / Migraine News From Medical News Today [2015.07.23]
New research suggests older people who experience migraines may have an increased risk of stroke, but only if they are smokers.

more news >>

Published Studies Related to Maxalt-Mlt (Rizatriptan)

Efficacy and tolerability of rizatriptan for the treatment of acute migraine in sumatriptan non-responders. [2011.05]
OBJECTIVE: The study was carried out to assess the efficacy and tolerability of rizatriptan orally disintegrating tablet (ODT) for treating acute migraine in patients who are non-responders to sumatriptan. BACKGROUND: Many migraineurs report dissatisfaction with sumatriptan efficacy. It is unclear whether sumatriptan 100 mg non-responders will respond to other triptans... CONCLUSION: Rizatriptan 10-mg ODT was superior to placebo at providing two-hour pain relief and two-hour pain freedom in the treatment of acute migraine in those who do not respond to sumatriptan 100 mg. Rizatriptan was generally well tolerated in this population.

A double-blind, randomized, multicenter, Italian study of frovatriptan versus rizatriptan for the acute treatment of migraine. [2011.04]
The objective of this study was to assess patient satisfaction with acute treatment of migraine with frovatriptan or rizatriptan by preference questionnaire. 148 subjects with a history of migraine with or without aura (IHS 2004 criteria), with at least one migraine attack per month in the preceding 6 months, were enrolled and randomized to frovatriptan 2.5 mg or rizatriptan 10 mg treating 1-3 attacks...

Rizatriptan reduces vestibular-induced motion sickness in migraineurs. [2011.02]
A previous pilot study suggested that rizatriptan reduces motion sickness induced by complex vestibular stimulation. In this double-blind, randomized, placebo-controlled study we measured motion sickness in response to a complex vestibular stimulus following pretreatment with either rizatriptan or a placebo...

Efficacy of frovatriptan in the acute treatment of menstrually related migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, comparative study versus rizatriptan. [2011]
The objectives of this study are to assess the efficacy and safety of frovatriptan, and rizatriptan in the subgroup of women with menstrually related migraine of a multicenter, randomized, double blind, cross-over study. Each patient received frovatriptan 2.5 mg or rizatriptan 10 mg in a randomized sequence: after treating 3 episodes of migraine in not more than 3 months with the first treatment, the patient had to switch to the other treatment...

A pilot study of rizatriptan and visually-induced motion sickness in migraineurs. [2009.08.06]
CONCLUSIONS: These pilot data suggest that rizatriptan does not consistently reduce visually-induced motion sickness in migraineurs. Rizatriptan may diminish motion sickness potentiation by cranial pain.

more studies >>

Clinical Trials Related to Maxalt-Mlt (Rizatriptan)

Drug Study in Pediatric Subjects With Migraines (MK0462-083 AM1) [Completed]
A study to assess the safety, tolerability, and single dose pharmacokinetics of a marketed drug in pediatric subjects with migraines. After completion of a portion of the study (Panels A and B), a regulatory agency issued an amended request that the 12-17 year old age group studied should include a similar number of male and female subjects. Therefore, the study was amended to add an additional panel of subjects (Panel C) to ensure gender balance specifically in this age group.

Study of Rizatriptan in the Treatment of Acute Attacks of Post-traumatic Headache in U.S. Military Troops [Withdrawn]

Long-Term Exposure to Rizatriptan 5-mg and 10-mg Oral Tablet (Combined Extension Protocols MK-0462-022, MK-0462-025, MK-0462-029) [Completed]

Rizatriptan 5 mg and 10 mg, Sumatriptan 100 mg, and Placebo Comparison Study (0462-030) [Completed]
A study to compare rizatriptan 10 mg verse sumatriptan 100 mg in the treatment of migraine attacks and duration of relief provided. This study will also provide additional efficacy data on rizatriptan 5 mg and 10 mg for the treatment of migraine.

A Study to Evaluate the Efficacy and Tolerability of Rizatriptan for Treatment of Acute Migraine in Children and Adolescents (MK-0462-082 AM7) [Completed]

more trials >>

Reports of Suspected Maxalt-Mlt (Rizatriptan) Side Effects

Drug Ineffective (3)Intestinal Ischaemia (2)Vomiting (2)Epilepsy (2)Abdominal Pain (1)Cardiac Tamponade (1)Contusion (1)Sudden Death (1)Abortion Spontaneous (1)Drug Label Confusion (1)more >>

Page last updated: 2015-11-25

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