ADVERSE REACTIONS
Leukopenia, anemia and thrombopenia occur frequently. Nausea and vomiting are the most commonly reported side effects.
Other adverse reactions are: Hematologic: Pancytopenia; eosinophilia; hemolytic anemia; bleeding tendencies such as petechiae, purpura, epistaxis and hemoptysis.
Gastrointestinal: Hepatic dysfunction, jaundice, stomatitis, hematemesis, melena, diarrhea, dysphagia, anorexia, abdominal pain, constipation, dry mouth.
Neurologic: Coma, convulsions, neuropathy, ataxia, paresthesia, nystagmus, diminished reflexes, falling, foot drop, headache, dizziness, unsteadiness. Cardiovascular: Hypotension, tachycardia, syncope.
Ophthalmic: Retinal hemorrhage, papilledema, photophobia, diplopia, inability to focus.
Respiratory: Pneumonitis, pleural effusion, cough.
Dermatologic: Herpes, dermatitis, pruritus, alopecia, hyperpigmentation, rash, urticaria, flushing. Allergic: Generalized allergic reactions. Genitourinary: Hematuria, urinary frequency, nocturia.
Musculoskeletal: Pain, including myalgia and arthralgia; tremors. Psychiatric: Hallucinations, depression, apprehension, nervousness, confusion, nightmares. Endocrine: Gynecomastia in prepubertal and early pubertal boys. Miscellaneous: Intercurrent infections, hearing loss, pyrexia, diaphoresis, lethargy, weakness, fatigue, edema, chills, insomnia, slurred speech, hoarseness, drowsiness.
Second nonlymphoid malignancies (including lung cancer, acute myelocytic leukemia and malignant myelosclerosis), and azoospermia have been reported in patients with Hodgkin's disease treated with procarbazine in combination with other chemotherapy and/or radiation. The risks of secondary lung cancer from treatment appear to be multiplied by tobacco use.
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REPORTS OF SUSPECTED MATULANE SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Matulane. The information is not vetted and should not be considered as verified clinical evidence.
Possible Matulane side effects / adverse reactions in 73 year old male
Reported by a physician from United States on 2011-12-02
Patient: 73 year old male
Reactions: Respiratory Failure, Neutropenic Sepsis
Adverse event resulted in: death
Suspect drug(s):
Matulane
Dosage: 100 mg;x1;po
Administration route: Oral
Indication: Hodgkin's Disease
Prednisone TAB
Indication: Hodgkin's Disease
Cyclophosphamide
Indication: Hodgkin's Disease
Etoposide
Indication: Hodgkin's Disease
Possible Matulane side effects / adverse reactions in 23 year old female
Reported by a consumer/non-health professional from United States on 2011-12-15
Patient: 23 year old female
Reactions: Hospitalisation
Adverse event resulted in: hospitalization
Suspect drug(s):
Matulane
Possible Matulane side effects / adverse reactions in 82 year old male
Reported by a individual with unspecified qualification from United States on 2011-12-15
Patient: 82 year old male weighing 71.2 kg (156.7 pounds)
Reactions: White Blood Cell Count Decreased, Colitis, Neutropenia, Escherichia Infection
Adverse event resulted in: hospitalization
Suspect drug(s):
Matulane
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