MATULANE SUMMARY
Matulane (procarbazine hydrochloride), a hydrazine derivative antineoplastic agent, is available as capsules containing the equivalent of 50 mg procarbazine as the hydrochloride.
Matulane is indicated for use in combination with other anticancer drugs for the treatment of Stage III and IV Hodgkin's disease. Matulane is used as part of the MOPP (nitrogen mustard, vincristine, procarbazine, prednisone) regimen.
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NEWS HIGHLIGHTS
Published Studies Related to Matulane (Procarbazine)
Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. [2006.06.20]
PURPOSE: Anaplastic oligodendrogliomas are more responsive to chemotherapy than high-grade astrocytomas. We investigated, in a multicenter randomized controlled trial, whether adjuvant procarbazine, lomustine, and vincristine (PCV) chemotherapy improves overall survival (OS) in newly diagnosed patients with anaplastic oligodendrogliomas or anaplastic oligoastrocytomas... CONCLUSION: Adjuvant PCV chemotherapy does not prolong OS but does increase PFS in anaplastic oligodendroglioma. Combined loss of 1p/19q identifies a favorable subgroup of oligodendroglial tumors. No genetic subgroup could be identified that benefited with respect to OS from adjuvant PCV.
Vinorelbine, gemcitabine, procarbazine and prednisone (ViGePP) as salvage therapy in relapsed or refractory aggressive non-Hodgkin's lymphoma (NHL): results of a phase II study conducted by the Gruppo Italiano per lo Studio dei Linfomi. [2006.03]
Patients with aggressive NHL who fail initial treatment or subsequently relapse have a very poor outcome and less than 20-25% achieve a prolonged disease-free interval with salvage therapies. To improve the outcome of patients with refractory aggressive NHL not suitable for High Dose Therapy (HDT) and Autologous Stem Cell Transplant (ASCT), the efficacy of a combination of gemcitabine, vinorelbine, procarbazine and prednisone (ViGePP) were tested.
Phase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or without BUdR for treatment of anaplastic astrocytoma: final report of RTOG 9404. [2004.03.15]
CONCLUSION: No survival advantage was noted by adding BUdR to EBRT and PCV in this patient population
Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme. [2000.10]
Although the efficacy of the nitrosourea-based combination chemotherapy procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosurea, and vincristine (PCV) has been previously demonstrated in the setting of anaplastic/intermediate-grade gliomas, the benefit for glioblastoma patients remains unproven...
A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse. [2000.09]
A randomized, multicentre, open-label, phase II study compared temozolomide (TMZ), an oral second-generation alkylating agent, and procarbazine (PCB) in 225 patients with glioblastoma multiforme at first relapse. Primary objectives were to determine progression-free survival (PFS) at 6 months and safety for TMZ and PCB in adult patients who failed conventional treatment...
Clinical Trials Related to Matulane (Procarbazine)
Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas [Active, not recruiting]
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Combining more than one drug may kill more tumor cells. It is not
yet known whether giving procarbazine alone or with isotretinoin is more effective for
recurrent primary malignant glioma.
PURPOSE: Randomized phase III trial to compare the effectiveness of procarbazine alone or
with isotretinoin in treating patients with recurrent primary malignant gliomas.
Thalidomide and Procarbazine in Treating Patients With Recurrent or Progressive Malignant Glioma [Completed]
RATIONALE: Thalidomide may stop the growth of malignant glioma by stopping blood flow to the
tumor. Drugs used in chemotherapy, such as procarbazine, work in different ways to stop tumor
cells from dividing so they stop growing or die. Combining thalidomide with procarbazine may
kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving thalidomide together with
procarbazine works in treating patients with recurrent or progressive malignant glioma.
SU-101 Compared With Procarbazine in Treating Patients With Glioblastoma Multiforme [Completed]
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. It is not yet known whether SU-101 is more effective than
procarbazine in treating patients with glioblastoma multiforme.
PURPOSE: Randomized phase III trial to compare the effectiveness of SU-101 with that of
procarbazine in treating patients with glioblastoma multiforme that has recurred.
Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and Cytarabine [Recruiting]
The purpose of this study is to evaluate two types of chemotherapy for primary central
nervous system lymphoma in the elderly (age older than 60) :
- Methotrexate, procarbazine, vincristine and cytarabine
- Methotrexate and temozolomide
Procarbazine in Treating Patients With Recurrent Brain Tumor [Completed]
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die.
PURPOSE: Phase I/II trial to study the effectiveness of procarbazine in treating patients who
have progressive or recurrent astrocytoma, oligodendroglioma, or glioblastoma multiforme
following treatment with radiation therapy.
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