Matulane (Procarbazine Hydrochloride) - Summary

MATULANE SUMMARY

Matulane (procarbazine hydrochloride), a hydrazine derivative antineoplastic agent, is available as capsules containing the equivalent of 50 mg procarbazine as the hydrochloride.

Matulane is indicated for use in combination with other anticancer drugs for the treatment of Stage III and IV Hodgkin's disease. Matulane is used as part of the MOPP (nitrogen mustard, vincristine, procarbazine, prednisone) regimen.

MATULANE NEWS HIGHLIGHTS

Published Studies Related to Matulane (Procarbazine)

Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. [2006.06.20]

Vinorelbine, gemcitabine, procarbazine and prednisone (ViGePP) as salvage therapy in relapsed or refractory aggressive non-Hodgkin's lymphoma (NHL): results of a phase II study conducted by the Gruppo Italiano per lo Studio dei Linfomi. [2006.03]

Phase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or without BUdR for treatment of anaplastic astrocytoma: final report of RTOG 9404. [2004.03.15]

Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme. [2000.10]

A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse. [2000.09]

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Clinical Trials Related to Matulane (Procarbazine)

Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas [Active, not recruiting]

Thalidomide and Procarbazine in Treating Patients With Recurrent or Progressive Malignant Glioma [Completed]

SU-101 Compared With Procarbazine in Treating Patients With Glioblastoma Multiforme [Completed]

Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and Cytarabine [Recruiting]

Procarbazine in Treating Patients With Recurrent Brain Tumor [Completed]

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