NEWS HIGHLIGHTS
Published Studies Related to Marqibo (Vincristine)
Iontophoretic vincristine in the treatment of postherpetic neuralgia: a
double-blind, randomized, controlled trial. [1999]
The effect of iontophoretic administration of vincristine in the treatment of
postherpetic neuralgia (PHN) was investigated in a prospective, double-blind,
placebo-controlled trial. Twenty patients with intercostal or lumbar PHN for more
than 6 months that was unresponsive to conventional medical therapy were
randomized to receive vincristine 0.01% (n = 11) or saline (n = 9), by
iontophoresis over 1 hour daily for 20 days...
Evolution of neuropathy and myopathy during intensive vincristine/corticosteroid
chemotherapy for non-Hodgkin's lymphoma. [1991]
Neuropathy and myopathy are common sequelae of intensive chemotherapy protocols
that contain vincristine and corticosteroids. The authors prospectively monitored
the evolution of neuropathy and myopathy during an intensive 12-week chemotherapy
program for patients with intermediate and high-grade non-Hodgkin's lymphoma...
Prospective clinical trial to compare vincristine and vinblastine in a COP-based
protocol for lymphoma in cats. [2013]
BACKGROUND: Current standard chemotherapy protocols for lymphoma in cats carry
risks of gastrointestinal toxicity, which can decrease quality of life and
complicate response assessment. Protocols with less gastrointestinal toxicity may
improve treatment tolerance... Baseline body weight remains a significant prognostic factor for cats
with lymphoma.
Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed
anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group
study 26951. [2013]
chemotherapy to radiotherapy (RT)... CONCLUSION: The addition of six cycles of PCV after 59.4 Gy of RT increases both
Cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab versus
epirubicin, cyclophosphamide, vinblastine, prednisone and rituximab for the
initial treatment of elderly "fit" patients with diffuse large B-cell lymphoma:
results from the ANZINTER3 trial of the Intergruppo Italiano Linfomi. [2012]
We conducted a prospective study to compare epirubicin, cyclophosphamide,
vinblastine, prednisone and rituximab (R-miniCEOP) with cyclophosphamide,
doxorubicin, vincristine, prednisone and rituximab (R-CHOP) for the treatment of
"fit" elderly patients with diffuse large B-cell lymphoma (DLBCL)... The less intense R-miniCEOP may
be an acceptable option for the treatment of relatively older patients with
low-risk disease.
Clinical Trials Related to Marqibo (Vincristine)
Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane Hydrochloride in Treating Young Patients With Relapsed or Refractory Solid Tumors, Lymphoma, or Leukemia [Terminated]
This phase I trial is studying the side effects and best dose of obatoclax mesylate when
given together with vincristine sulfate, doxorubicin hydrochloride, and dexrazoxane
hydrochloride in treating young patients with relapsed or refractory solid tumors, lymphoma,
or leukemia. Obatoclax mesylate may stop the growth of cancer cells by blocking some of the
proteins needed for cell growth and causing the cells to self-destruct. Drugs used in
chemotherapy, such as vincristine sulfate, doxorubicin hydrochloride, and dexrazoxane
hydrochloride, work in different ways to stop the growth of cancer cells, either by killing
the cells or by stopping them from dividing. Giving obatoclax mesylate together with
combination chemotherapy may kill more cancer cells.
A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors [Recruiting]
In this research study we want to learn more about which treatment works better for patients
diagnosed with a vascular tumor called Kaposiform Hemangioendothelioma (KHE) or other high
risk vascular tumors such as Tufted Angioma (TA). In these tumors, the blood cells that
help your blood clot called platelets become trapped in the tumor causing swelling, pain,
and bruising. Vascular tumors can be life threatening. There are few medical treatments that
will work to shrink the vascular tumor. Some doctors will use steroids and vincristine to
try and shrink vascular tumors.
In this research study, the study doctor will compare two different drugs to see which one
will work better to help shrink your vascular tumor. One of the drugs is vincristine.
Vincristine is approved by the Food and Drug Administration (FDA) to treat people with
cancer. Vincristine is used to stop the abnormal cells from growing such as cells that make
up blood vessels.
The other drug to be used in this study is sirolimus. Sirolimus is currently approved by the
Food and Drug Administration (FDA) to prevent transplanted organ rejection. Sirolimus is not
approved by the FDA for treatment of vascular abnormalities and is considered experimental.
Sirolimus belongs to a class of drugs call 'mTOR inhibitors'. mTOR (mammilian target of
rapamycin) helps cells to grow and may also help blood vessels to grow in a more normal
fashion. Sirolimus is currently being tested in patients with vascular tumors and cancer. In
vascular tumors, we hope sirolimus will stop the blood vessel growth.
Funding Source: FDA - OOPD (Office of Orphan Products Development)
Clinical Trial of Vincristine vs. Prednisolone for Treatment of Complicated Hemangiomas [Terminated]
The goal of this study is to determine the safety and efficacy of Prednisolone and
Vincristine for treatment of large, complicated infantile hemangiomas. The diagnostic,
therapeutic and response criteria experimentally determined in this study will be used as a
framework for future infantile hemangioma studies.
Vincristine Sulfate Liposome in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia [Recruiting]
This pilot phase II trial studies how well vincristine sulfate liposome works in treating
patients with acute myeloid leukemia that has returned after a period of improvement or has
not responded to previous treatment. Drugs used in chemotherapy, such as vincristine sulfate
liposome, work in different ways to stop the growth of cancer cells, either by killing the
cells, by stopping them from dividing, or by stopping them from spreading. Liposomal
encapsulation prolongs bioavailability (proportion of drug that enters the circulation when
introduced into the body) of vincristine sulfate, and may increase its delivery to cancer
cells with fewer side effects.
To Evaluate the Safety, Activity and Pharmacokinetics of Marqibo in Children and Adolescents With Refractory Cancer [Completed]
Background:
- Marqibo(Registered Trademark) is a new anticancer drug. It combines Vincristine
sulfate, which is a widely used anticancer drug, and packages it into a tiny fat bubble
known as a liposome. The goal of this is to improve the drug's ability to destroy
cancer cells and help reduce the potential side effects of treatment.
- Vincristine sulfate was originally developed from chemicals found in the periwinkle
plant and acts against multiple types of malignant cancer. It is approved for multiple
cancer types including solid tumors and blood cancers.
- Research has shown that Marqibo(Registered Trademark) is able to slow or stop the
growth of cancer cells in some adults, both alone and in combination with other
chemotherapy drugs, but more research is needed to determine its use in children.
- There has been one previous small study of Marqibo(Registered Trademark) in children.
Although some anti-cancer activity was seen, side effects and optimal dosing were not
fully determined.
- As is seen with standard Vincristine suflate, the most common side effect of
Marqibo(Registered Trademark) involves the nervous system. It can cause numbness and
tingling in the hands and feet. Symptoms commonly improve when the drug is discontinued
or the dose is lowered.
Objectives:
- To determine the safety and efficacy of Marqibo as a treatment for children who have been
diagnosed with certain types of malignant cancer that has not responded to standard
treatment.
Eligibility:
- Children and adolescents between 2 and 21 years of age who have been diagnosed with
certain types of malignant cancer that has not responded to standard treatment.
- These cancer types include solids tumors, primary brain tumors, leukemias, and
lymphomas....
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