Bupivacaine hydrochloride is 2-Piperidinecarboxamide, 1-butyl- N -(2,6-dimethylphenyl)-, monohydrochloride, monohydrate, a white crystalline powder that is freely soluble in 95 percent ethanol, soluble in water, and slightly soluble in chloroform or acetone.
MARCAINE Spinal is indicated for the production of subarachnoid block (spinal anesthesia).
Standard textbooks should be consulted to determine the accepted procedures and techniques for the administration of spinal anesthesia.
Media Articles Related to Marcaine Spinal (Bupivacaine Intraspinal)
Combining dental, medical procedures may safely limit children's anesthesia exposure
Source: Dentistry News From Medical News Today [2016.10.27]
Children who require both dental and non-dental medical procedures should have them completed under one general anesthesia session whenever possible, which is ideal for both the patient and family...
Trends in Tramadol: Pharmacology, Metabolism, and Misuse
Source: Medscape Anesthesiology Headlines [2017.02.15]
Learn about the unique characteristics of tramadol, its pharmacogenomic considerations, and its potential for abuse in this comprehensive review.
Anesthesia & Analgesia
UW study: Incidence of consciousness during surgery lower than previous estimates
Source: Pain / Anesthetics News From Medical News Today [2016.12.19]
An international study of 260 surgical patients found that, contrary to many previous studies, just more than four percent were conscious of the external world while under general anesthesia but...
Published Studies Related to Marcaine Spinal (Bupivacaine Intraspinal)
Spinal anaesthesia for pelvic surgery: low concentrations of lignocaine and
bupivacaine are effective with less adverse events. 
subarachnoid block for pelvic surgeries... CONCLUSION: [corrected] For subarachnoid block for pelvic surgeries longer than
The effect of preemptive analgesia with bupivacaine on postoperative pain of
inguinal hernia repair under spinal anesthesia: a randomized clinical trial. 
conducted to provide some evidence for possible benefits of such practice... CONCLUSION: The pre-operative local infiltration of bupivacaine reduces pain,
Periarticular infiltration of 0.25% bupivacaine on top of femoral nerve block and
intrathecal morphine improves quality of pain control after total knee
arthroplasty: a randomized double-blind placebo controlled clinical trial. 
CONCLUSION: Adding periarticular infiltration to femoral block and intrathecal
Does the baricity of bupivacaine influence intrathecal spread in the prolonged sitting position before elective cesarean delivery? A prospective randomized controlled study. [2011.10]
BACKGROUND: Difficulties in inserting an epidural catheter while performing combined spinal-epidural anesthesia for cesarean delivery may lead to undue delays between the spinal injection of the local anesthetic mixture and the adoption of the supine position with lateral tilt. We hypothesized that this delay may affect the intrathecal distribution of local anesthetic of different baricities such that hypobaric local anesthetic would lead to a higher sensory block level... CONCLUSIONS: We demonstrated that when parturients undergoing cesarean delivery were maintained in the sitting position for 5 minutes after spinal injection of the local anesthetic, hypobaric bupivacaine resulted in sensory block levels that were higher compared with isobaric and hyperbaric bupivacaine, respectively, during the study period.
Subarachnoid bupivacaine and pethidine for caesarean section: assessment of quality of perioperative analgesia and side effects. [2011.09]
AIMS AND OBJECTIVES: This study determined the quality of perioperative analgesia and side effect profile of spinal bupivacaine plus pethidine for caesarean section... CONCLUSION: Bupivacaine with pethidine 7.5mg resulted in better quality of anaesthesia, longer postoperative analgesia with acceptable side effect profile. This will be of value in the management of post-caesarean section pain particularly in the resource poor setting.
Clinical Trials Related to Marcaine Spinal (Bupivacaine Intraspinal)
Marcaine Use in Laparoscopic Gynecological Surgery [Terminated]
Comparison of Standard and Minidose Spinal Anesthesia for Cesarean Section Operation Using Marcaine Spinal 0.5% Heavy [Not yet recruiting]
The objectives of this study is to test a combination of low dose local anesthetic
Bupivacaine diluted in patient's CSF with lipophilic opiate Fentanyl for optimal spinal
anesthesia during Cesarean Section. The dilution of Bupivacaine with CSF in our study would
result in effective spinal anesthesia with relatively limited motor block, quick recovery of
motor function and relatively long lasting analgesia. We expect lower incidence of side
effects with this combination than with convenient dose of Bupivacaine.
2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula [Recruiting]
ED50 and ED95 of Intrathecal Bupivacaine With or Without Epinephrine for Total Knee Replacement Arthroplasty [Completed]
This prospective randomized double-blind dose-response study is aimed to investigate the
ED50 and ED95 of intrathecal bupivacaine with or without epinephrine 100 mcg for total knee
Determination of the Effective Volume of 0.125% Bupivacaine-fentanyl 5mcg/mL in Labour Epidurals [Completed]
Different medications can be used as analgesics in labor epidurals. Bupivacaine is one of
the most commonly used drugs for that purpose. The efficacy of a certain medication injected
epidurally depends on the dose that is given. A certain dose can be administered in
different concentrations, which will consequently mean different volumes. Studies have been
done to determine volumes for different concentrations of bupivacaine. However, those
studies fall short in the sense that this information cannot be readily applicable in
clinical practice, as we don't use bupivacaine plain. The combination of bupivacaine and
fentanyl or sufentanil is common practice, as it is well established that the opioids will
reduce the concentration of local anesthetic required to produce optimal effect with the
least side effects.
This study is being planned to determine and compare the EV90 of the bupivacaine
0. 125%-fentanyl mixture for initiation of labor epidural analgesia, following the
administration of the 2 different test doses (3cc of lidocaine 2% or 3cc of the bupivacaine
0. 125%-fentanyl mixture) used in our Department.