Mafenide Acetate, USP is a synthetic antimicrobial agent designated chemically as α-amino- p -toluenesulfonamide monoacetate.
Mafenide Acetate,USP For 5% Topical Solution is indicated for use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.
Clinical Trials Related to Mafenide
Prospective Evaluation of the Effects of Topical Therapy With SulfamylonŽ For 5% Topical Solution on Autograft Healing in Subjects With Thermal Injuries Requiring Meshed Autografts: A Comparison to a Historical Control Group [Completed]
The primary objective is to compare the effectiveness of treatment with SulfamylonŽ solution
as the initial topical moist dressing over meshed autografts following the initial graft
procedure on preventing graft loss in a prospective cohort of subjects versus a historical
control group in a non-inferiority trial.
Study of the Treatment of Burn Wounds With Antimicrobial Topical Soaks [Terminated]
Determine effectiveness of various antimicrobial solutions on burn wounds (infections, wound
healing, length of hospital stay).
Patients Response to Early Switch To Oral:Osteomyelitis Study [Not yet recruiting]
Based on the current literature, investigators hypothesize that patients with osteomyelitis
who are treated with the standard approach of intravenous antibiotics for the full duration
of therapy will have the same clinical outcomes as patients treated with the experimental
approach of intravenous antibiotics with early switch to oral antibiotics.
The primary objective of this study is to compare patients with osteomyelitis treated with
the standard approach of intravenous antibiotics for the full duration of therapy versus
patients treated with intravenous antibiotics with an early switch to oral antibiotics in
relation to clinical outcomes at 12 months after discontinuation of antibiotic therapy.
Secondary objectives of the study include the evaluation of adverse events related to the
use of antibiotics as well as the cost of care evaluated from the hospital perspective.
Study of Low Adherent Dressing Versus the Standard of Care for the Management of Skin Grafts Over Thermal Burns [Active, not recruiting]
The purpose of this study is to evaluate the P6 Low Adherent Study Dressing relative to the
Standard of Care (SOC, Mafenide Acetate 5% Solution) for the management of skin grafts in
burn wounds resulting from thermal burn injuries.
Page last updated: 2013-02-14