LYSODREN (mitotane tablets, USP) should be administered under the supervision of a qualified physician experienced in the uses of cancer chemotherapeutic agents. LYSODREN should be temporarily discontinued immediately following shock or severe trauma since adrenal suppression is its prime action. Exogenous steroids should be administered in such circumstances, since the depressed adrenal may not immediately start to secrete steroids.
LYSODREN® (mitotane tablets, USP) is an oral chemotherapeutic agent.
LYSODREN is indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types.
Published Studies Related to Lysodren (Mitotane)
Effect of mitotane on pituitary corticotrophs in clinically normal dogs. [2006.08]
OBJECTIVE: To evaluate the effects of mitotane administration on the function and morphology of pituitary corticotrophs in clinically normal dogs...
The combination of insulin-like growth factor receptor 1 (IGF1R) antibody
cixutumumab and mitotane as a first-line therapy for patients with
recurrent/metastatic adrenocortical carcinoma: a multi-institutional
NCI-sponsored trial. 
Adrenocortical carcinoma (ACC) is an aggressive malignancy, which lacks an
effective systemic treatment. Abnormal activation of insulin-like growth factor
receptor 1 (IGF1R) has been frequently observed...
[Mitotane as possible cause of acute intermittent porphyria]. [2011.09.12]
A 54 year-old woman with acute intermittent porphyria (AIP) developed an attack of porphyria after 156 days of treatment with mitotane following a non-radical adrenalectomy for adrenocortical carcinoma. Mitotane therapy was discontinued but the attack of porphyria persisted for more than four months and included episodes with severe metabolic and neurologic toxicities.
Plasma concentrations of o,p'DDD, o,p'DDA, and o,p'DDE as predictors of tumor response to mitotane in adrenocortical carcinoma: results of a retrospective ENS@T multicenter study. [2011.06]
CONCLUSIONS: Our data confirm the value of o,p'DDD plasma monitoring as well as targeting the 14 mg/liter cutoff level in the therapeutic management of ACC patients. Furthermore, our results suggest additional benefit of higher levels of o,p'DDD and combined measurement of o,p'DDD and o,p'DDA.
High (18)F-FDG uptake by the remaining adrenal gland four months after surgery and initiation of mitotane treatment in two patients with adrenocortical carcinoma. [2011.05]
Two men, one 42 and the other 35 years old were both subjected to adrenalectomy for adrenocortical carcinoma (ACC). Adjuvant treatment with mitotane [o,p-dichloro-diphenyl-dichloroethane, (o,p-DDD)], was initiated following surgery... In conclusion, an abnormal high (18)F-FDG uptake was observed in the contralateral adrenal gland in both our adrenalectomized ACC patients, 4 months after starting mitotane treatment, probably related to mitotane's effect on steroid metabolism, not yet fully understood.
Clinical Trials Related to Lysodren (Mitotane)
Efficacy of Adjuvant Mitotane Treatment (ADIUVO) [Recruiting]
Study Rationale Adrenocortical carcinoma (ACC) is a very rare disease with a high risk of
relapse after radical surgery. The efficacy of adjuvant mitotane treatment is suggested by a
retrospective multicenter international study showing that postoperative mitotane treatment
was associated with a significant reduction of the risk of relapse and death. However, these
promising results need confirmation in a randomized prospective study. Caution should be
adopted particularly in patients with low risk of disease relapse, in whom the benefit of
therapy should be weighted against the side effects. Even if an adjuvant treatment seems
justified in patients at high risk of relapse, a randomised prospective study is needed to
assess whether such a treatment is efficacious in patients at low-intermediate risk.
The purpose of the present study is to determine whether adjuvant mitotane treatment is
effective in prolonging the disease free survival in patients with adrenocortical carcinoma
at low-intermediate risk of progression who underwent radical resection
A Safety and Feasibility Study of Mitotane in Prostate Cancer [Active, not recruiting]
1. The primary objective of this study is to assess the feasibility of treating patients
with metastatic castration resistant prostate cancer with mitotane. Secondary
objectives are to assess safety and tolerability as well as response rate of therapy
2. To assess the toxicity of Mitotane in men with HRPC
3. To assess the relationship between baseline serum adrenal androgens and their response
IMC-A12 With Mitotane vs Mitotane Alone in Recurrent, Metastatic, or Primary ACC That Cannot Be Removed by Surgery [Terminated]
This randomized phase II trial is studying mitotane and IMC-A12 to see how well they work
compared with mitotane alone in treating patients with recurrent, metastatic, or primary
adrenocortical cancer that cannot be removed by surgery. Drugs used in chemotherapy, such as
mitotane, work in different ways to stop the growth of tumor cells, either by killing the
cells or by stopping them from dividing. Monoclonal antibodies, such as IMC-A12, can block
tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
Others find tumor cells and help kill them or carry tumor-killing substances to them. It is
not yet known whether mitotane is more effective with or without monoclonal antibody IMC-A12
in treating adrenocortical cancer.
Evaluation of Side Effects of Mitotane [Recruiting]
Mitotane is standard therapy in the treatment of adrenocortical carcinoma. However, many
side effects are not well documented. Therefore, we are aiming at collecting data about side
effects in patients treated with mitotane
A Study of Combination Chemotherapy and Surgical Resection in the Treatment of Adrenocortical Carcinoma: Continuous Infusion Doxorubicin, Vincristine and Etoposide With Daily Mitotane Before and After Surgical Resection [Completed]
Patients who have no response to preoperative chemotherapy and no residual disease following
surgery on Regimen A are treated on Regimen B postoperatively.
The following acronyms are used:
DDD Mitotane, NSC-38721
DOX Doxorubicin, NSC-123127
VCR Vincristine, NSC-67574
VP-16 Etoposide, NSC-141540
Regimen A: 4-Drug Combination Chemotherapy followed by Surgery followed by 4-Drug
Combination Chemotherapy. DDD/DOX/VCR/VP-16; followed by surgical debulking; followed by
Regimen B: Single-Agent Chemotherapy. DDD.
Reports of Suspected Lysodren (Mitotane) Side Effects
Altered State of Consciousness (5),
Adrenal Insufficiency (4),
OFF Label USE (3),
Gamma-Glutamyltransferase Increased (3),
Cytolytic Hepatitis (3),
Neoplasm Progression (2), more >>
Page last updated: 2015-08-10