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Lyrica (Pregabalin) - Summary



Pregabalin is a drug with anti-seizure and anti-nociceptive properties.

LYRICA is indicated for:

  • Management of neuropathic pain associated with diabetic peripheral neuropathy
  • Management of postherpetic neuralgia
  • Adjunctive therapy for adult patients with partial onset seizures
  • Management of fibromyalgia
  • Management of neuropathic pain associated with spinal cord injury

See all Lyrica indications & dosage >>


Published Studies Related to Lyrica (Pregabalin)

The efficacy of pregabalin for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled double-blind study. [2015]
DESIGN: Prospective, randomized, placebo controlled, double blinded study... CONCLUSION: Pretreatment with pregabalin 150 mg prevents CRBD and also decreases

Pre-emptive analgesia with pregabalin and celecoxib decreases postsurgical pain following maxillomandibular advancement surgery: a randomized controlled clinical trial. [2014]
obstructive sleep apnea... CONCLUSION: Within the limitations of this study, a 1-time preoperative oral dose

Evaluation of the efficacy and safety of pregabalin, venlafaxine, and carbamazepine in patients with painful diabetic peripheral neuropathy. A randomized, double-blind trial. [2014]
venlafaxine in patients with painful diabetic neuropathy (PDN)... CONCLUSION: This study showed the efficacy of venlafaxine, pregabalin, and

Adjunctive use of controlled-release pregabalin in adults with treatment-resistant partial seizures: a double-blind, randomized, placebo-controlled trial. [2014]
OBJECTIVES: To assess the efficacy and tolerability of add-on pregabalin controlled-release formulation (PGB-CR) (doses of 165 or 330 mg/day) in patients with partial-onset seizures (POS). METHODS: This was a randomized, double-blind (DB), parallel-group study of PGB-CR once-daily as adjunctive treatment in adults with treatment-resistant partial seizures...

Comparison of pregabalin with pramipexole for restless legs syndrome. [2014]
alternative... CONCLUSIONS: Pregabalin provided significantly improved treatment outcomes as

more studies >>

Clinical Trials Related to Lyrica (Pregabalin)

Efficacy And Safety Study Of Pregabalin (Lyrica) As Monotherapy In Patients With Partial Seizures [Recruiting]
This study will determine the safety and efficacy of pregabalin (Lyrica) when administered by itself (without any other anti-epileptic medication) to epilepsy subjects for the treatment of partial seizures. The duration of the trial is about 6 months.

Pregabalin and Orofacial Neuropathic Pain [Recruiting]
The purpose of this study is to determine whether pregabalin can decrease pain and improve quality of life in patients who have nerve pain on the mouth or the face

Safety and Efficacy Evaluation Of Pregabalin (Lyrica) With Patients With Generalized Anxiety Disorder [Recruiting]
The purpose of this study is to characterize the safety and efficacy in patients with generalized anxiety disorder after short- (3 months) and long-term (6 months) use of Pregabalin (Lyrica).

Pregabalin for the Treatment of Vulvodynia [Recruiting]
The purpose of this study is to determine whether pregabalin is effective in the treatment of vulvodynia.

Special Investigation of Pregabalin for Fibromyalgia (Regulatory Post Marketing Commitment Plan) [Not yet recruiting]

more trials >>

Reports of Suspected Lyrica (Pregabalin) Side Effects

Pain (1561)Drug Ineffective (952)Dizziness (696)Weight Increased (605)Feeling Abnormal (562)Somnolence (501)Malaise (471)Pain in Extremity (471)Oedema Peripheral (440)Insomnia (373)more >>


Based on a total of 30 ratings/reviews, Lyrica has an overall score of 5.80. The effectiveness score is 6.73 and the side effect score is 5.67. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Lyrica review by 46 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   Fibromyalgia
Dosage & duration:   150mg taken 2x per day for the period of Still taking it
Other conditions:   None
Other drugs taken:   None
Reported Results
Benefits:   Lyrica has made a huge difference with my fibromyalgia pain. I have had fibromyalgia for 13 plus years and was excited about the FDA finally approving Lyrica for fibromyalgia patients. I would recomend that anyone suffering from fibromyalgia try this medication, along with a healthy diet and exercise. Lyrica is not a cure, but I have improved probably 75% over this last year.
Side effects:   It took my body 3-4 weeks to get used to Lyrica. It did make me feel a little different "high" would probably be the best way to describe it. I have since adjusted and have had no further side effects.
Comments:   Started with 50 mg 2x a day (morning and afternoon), then gradually built up to 150mg 2x a day.


Lyrica review by 63 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   fibromylgia
Dosage & duration:   5 0mg. taken 2 to 3 times day for the period of app. 4 yrs.
Other conditions:   arthritis- asteproesis
Other drugs taken:   zanaz- lorotab- pristiq
Reported Results
Benefits:   the benefits foe the pain was good, it helped the constant pain i was having in my muscles and the over all aching
Side effects:   sleepiness- fatigu memory loss- confusion-depression- trouble breathigng
Comments:   good relief from pain . i take 100mg. at bed time it helps me sleep well but am tired in the am. it makes me just want to lie on couch and sleep all day this makes my arthritis worse. am tired and draggy all day with no desire to do any thing, even the thing that have always interested me.am prescribed one 50g for daytimebut cannot tolerate it because i will sleep all day and be very light headed and unable to concentrate.


Lyrica review by 58 year old female patient

Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   neuropathic pain aand fibromyalgia
Dosage & duration:   300mg/day taken 150mg twice/day for the period of 2 months
Other conditions:   severe spasms, severe osteoarthritis, migraines
Other drugs taken:   Klonopin, Ultram
Reported Results
Benefits:   None
Side effects:   Extreme swelling of face, hands and feet, as well as, raised welts on skin
Comments:   Patient was being weened off of 3600mg/day of Neurontin on to Lyrica. As the dosage taken of Neurontin lessened and that of Lyrica increased so did the side effects. Patient was taken totally off of Lyrica and, successfully, placed back on Neurontin.

See all Lyrica reviews / ratings >>

Page last updated: 2015-08-10

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