Lyrica (Pregabalin) - Summary

LYRICA SUMMARY

LYRICA (pregabalin) binds with high affinity to the alpha₂-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin is unknown, results with genetically modified mice and with compounds structurally related to pregabalin (such as gabapentin) suggest that binding to the alpha₂-delta subunit may be involved in pregabalin's antinociceptive and antiseizure effects in animal models. In vitro, pregabalin reduces the calcium-dependent release of several neurotransmitters, possibly by modulation of calcium channel function.

LYRICA is indicated for:

Management of neuropathic pain associated with diabetic peripheral neuropathy

Management of postherpetic neuralgia

Adjunctive therapy for adult patients with partial onset seizures

Management of fibromyalgia

See all Lyrica indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Lyrica (Pregabalin)

Effects of pregabalin on central sensitization in patients with chronic pancreatitis in a randomized, controlled trial. [2012]
sensory testing (QST)... CONCLUSION: Our study provides first evidence that pregabalin has moderate

Pregabalin and gabapentin for post-photorefractive keratectomy pain: a randomized controlled trial. [2012]
post-photorefractive keratectomy (PRK) pain... CONCLUSIONS: Pregabalin and gabapentin seem to be helpful in alleviating post-PRK

Safety profile and tolerability of up to 1 year of pregabalin treatment in 3 open-label extension studies in patients with fibromyalgia. [2012]
mg BID) treatment for up to 1 year in patients with FM... CONCLUSIONS: The data from these extension studies suggest that the adverse event

Addition of pregabalin to multimodal analgesic therapy following ankle surgery: a randomized double-blind, placebo-controlled trial. [2012]
opioid and pregabalin adverse effects... CONCLUSIONS: No clinical benefit was obtained from perioperative administration

The adverse event profile of pregabalin across different disorders: a meta-analysis. [2012]
in which PGB was investigated... CONCLUSIONS: Although drug-resistant partial epilepsy is associated with a higher

more studies >>

Clinical Trials Related to Lyrica (Pregabalin)

Efficacy And Safety Study Of Pregabalin (Lyrica) As Monotherapy In Patients With Partial Seizures [Recruiting]
This study will determine the safety and efficacy of pregabalin (Lyrica) when administered by itself (without any other anti-epileptic medication) to epilepsy subjects for the treatment of partial seizures. The duration of the trial is about 6 months.

Pregabalin and Orofacial Neuropathic Pain [Recruiting]
The purpose of this study is to determine whether pregabalin can decrease pain and improve quality of life in patients who have nerve pain on the mouth or the face

Safety and Efficacy Evaluation Of Pregabalin (Lyrica) With Patients With Generalized Anxiety Disorder [Recruiting]
The purpose of this study is to characterize the safety and efficacy in patients with generalized anxiety disorder after short- (3 months) and long-term (6 months) use of Pregabalin (Lyrica).

A Placebo-Controlled Trial of Pregabalin (Lyrica) for Irritable Bowel Syndrome [Recruiting]
This study is being done to see if Lyrica helps people with irritable bowel syndrome, otherwise known as "IBS". Lyrica is the trade name for pregabalin, which was first approved by the FDA in June 2005 and has been available through prescription since fall 2005, and is marketed by Pfizer. Lyrica is known to have clinical efficacy treating pain disorders including IBS-related conditions such as fibromyalgia.

A Study of Pregabalin (Lyrica) Augmentation in Serotonin Reuptake Inhibitor-Refractory Obsessive Compulsive Disorder [Recruiting]
This study will examine the efficacy of pregabalin (Lyrica) added to SRI treatment in OCD for individuals who have not responded or only partially responded to an adequate trial of SRI. Although SRIs have demonstrated efficacy in OCD in numerous placebo-controlled trials, response rates have been as low as 40%. Augmentation strategies would be beneficial to maximize treatment response in OCD.

Pregabalin (Lyrica) is an anticonvulsant medication that appears to have a novel mechanism of action. It has been shown to enhance activity at gamma-amino-butyric acid (GABA) receptors as well as inhibit glutamate release. These two neurotransmitters systems have been implicated in the neurobiology of OCD.

The study will consist of patients who have not attained full response to an SRI. The patients will be randomized in a double-blind fashion to augmentation with pregabalin (Lyrica) or placebo. The dose of study medication will be flexible, starting at 75 mg/day and increasing in 75 mg increments to a maximum of 600 mg/day, based on efficacy and any side effects. Patients' response to treatment will be measured by the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Montgomery Asberg Depression Rating Scale (MADRS), and the Clinical Global Impression Scale(CGI).

more trials >>

Reports of Suspected Lyrica (Pregabalin) Side Effects

Pain (1561),  Drug Ineffective (952),  Dizziness (696),  Weight Increased (605),  Feeling Abnormal (562),  Somnolence (501),  Malaise (471),  Pain in Extremity (471),  Oedema Peripheral (440),  Insomnia (373), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Lyrica review by 46 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Fibromyalgia
Dosage & duration:		150mg taken 2x per day for the period of Still taking it
Other conditions:		None
Other drugs taken:		None
		Reported Results
Benefits:		Lyrica has made a huge difference with my fibromyalgia pain. I have had fibromyalgia for 13 plus years and was excited about the FDA finally approving Lyrica for fibromyalgia patients. I would recomend that anyone suffering from fibromyalgia try this medication, along with a healthy diet and exercise. Lyrica is not a cure, but I have improved probably 75% over this last year.
Side effects:		It took my body 3-4 weeks to get used to Lyrica. It did make me feel a little different "high" would probably be the best way to describe it. I have since adjusted and have had no further side effects.
Comments:		Started with 50 mg 2x a day (morning and afternoon), then gradually built up to 150mg 2x a day.

Lyrica review by 63 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		fibromylgia
Dosage & duration:		5 0mg. taken 2 to 3 times day for the period of app. 4 yrs.
Other conditions:		arthritis- asteproesis
Other drugs taken:		zanaz- lorotab- pristiq
		Reported Results
Benefits:		the benefits foe the pain was good, it helped the constant pain i was having in my muscles and the over all aching
Side effects:		sleepiness- fatigu memory loss- confusion-depression- trouble breathigng
Comments:		good relief from pain . i take 100mg. at bed time it helps me sleep well but am tired in the am. it makes me just want to lie on couch and sleep all day this makes my arthritis worse. am tired and draggy all day with no desire to do any thing, even the thing that have always interested me.am prescribed one 50g for daytimebut cannot tolerate it because i will sleep all day and be very light headed and unable to concentrate.

Lyrica review by 58 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		neuropathic pain aand fibromyalgia
Dosage & duration:		300mg/day taken 150mg twice/day for the period of 2 months
Other conditions:		severe spasms, severe osteoarthritis, migraines
Other drugs taken:		Klonopin, Ultram
		Reported Results
Benefits:		None
Side effects:		Extreme swelling of face, hands and feet, as well as, raised welts on skin
Comments:		Patient was being weened off of 3600mg/day of Neurontin on to Lyrica. As the dosage taken of Neurontin lessened and that of Lyrica increased so did the side effects. Patient was taken totally off of Lyrica and, successfully, placed back on Neurontin.