Important Points to Remember
Twenty-eight (28) yellow tablets each containing 90 mcg of levonorgestrel, a totally synthetic progestogen, and 20 mcg of ethinyl estradiol.
Lybrel is indicated for the prevention of pregnancy in women who elect to use oral contraceptives as a method of contraception.
Media Articles Related to Lybrel (Levonorgestrel / Ethinyl Estradiol)
First scientific data for Lybrel presented at ASRM meeting
Source: The Doctors Lounge - Gynecology
Lybrel is an investigational combination low-dose oral contraceptive designed to be taken daily, 365 days a year.
Research reveals more than half of young women who have abortions were using contraception when they fell pregnant
Source: Abortion News From Medical News Today [2014.04.30]
Reproductive health charity Marie Stopes UK has launched the findings of the first research in the UK into the contraceptive use of women aged 16-24 having one or more abortions.
New study finds that the probability of unprotected intercourse in hookups doubles between freshman
Source: Sexual Health / STDs News From Medical News Today [2014.10.20]
An article released by Social Forces titled, "Casual Contraception in Casual Sex: Life-Cycle Change in Undergraduates' Sexual Behavior in Hookups" by Jonathan Marc Bearak (New York University)...
Free birth control reduces teen pregnancies and abortions
Source: Abortion News From Medical News Today [2014.10.03]
Teens who received free contraception and were educated about the pros and cons of various birth control methods were dramatically less likely to get pregnant, give birth or get an abortion compared...
Published Studies Related to Lybrel (Levonorgestrel / Ethinyl Estradiol)
Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17beta-estradiol, compared with those of levonorgestrel/ethinyl estradiol. A double-blind, randomised study. [2011.03]
Use of oral contraceptives (OC) that combine a progestogen with synthetic ethinyl estradiol (EE) is associated with increased risk of venous thromboembolism. NOMAC/E2 is a new monophasic OC that combines nomegestrol acetate (NOMAC), a highly selective progestogen, with 17beta-estradiol (E2)...
Continuous, daily levonorgestrel/ethinyl estradiol vs. 21-day, cyclic levonorgestrel/ethinyl estradiol: efficacy, safety and bleeding in a randomized, open-label trial. [2009.12]
BACKGROUND: This Phase 3, randomized, open-label, multicenter study conducted at 44 sites in Europe evaluated the safety and efficacy of a continuous, daily regimen of levonorgestrel (LNG) 90 mcg/ethinyl estradiol (EE) 20 mcg compared with a 21-day, cyclic LNG 100 mcg/EE 20 mcg regimen... CONCLUSIONS: Continuous LNG 90 mcg/EE 20 mcg was shown to be a safe and effective OC in this direct comparison to a cyclic OC. Suppression of menses and the potential for no bleeding requiring sanitary protection may be provided by this continuous, low-dose OC.
Cycle control with oral contraceptives containing 20 micrograms of ethinyl estradiol. A multicenter, randomized comparison of levonorgestrel/ethinyl estradiol (100 micrograms/20 micrograms) and norethindrone/ethinyl estradiol (1000 micrograms/20 micrograms). [1999.03]
A randomized, open-label, multicenter study was undertaken to compare the effects of oral contraceptives (OC) containing 100 micrograms levonorgestrel (LNG)/20 micrograms ethinyl estradiol (EE) (Aless/Loette) and 1000 micrograms norethindrone acetate (NETA)/20 micrograms EE (Loestrin Fe 1/20) on menstrual cycle control over four cycles of use...
Continuous oral levonorgestrel/ethinyl estradiol for treating premenstrual dysphoric disorder. [2012.01]
BACKGROUND: The study was conducted to investigate continuous daily levonorgestrel 90 mcg/ethinyl estradiol 20 mcg (LNG/EE) on premenstrual dysphoric disorder (PMDD)... CONCLUSIONS: Continuous daily LNG 90 mcg/EE 20 mcg was well tolerated and may be useful for managing the physical, psychological and behavioral symptoms and loss of work productivity related to PMDD. Copyright (c) 2012 Elsevier Inc. All rights reserved.
Ovarian activity and safety of a novel levonorgestrel/ethinyl estradiol continuous oral contraceptive regimen. [2009.09]
BACKGROUND: A continuous regimen of oral levonorgestrel (LNG) 90 mcg/ethinyl estradiol (EE) 20 mcg was evaluated for inhibition of ovulation, time to return to ovulation after stopping treatment and safety... CONCLUSIONS: The continuous LNG/EE regimen completely inhibited ovulation, with little evidence of follicular development and with rapid return of ovulatory capacity after stopping treatment.
Clinical Trials Related to Lybrel (Levonorgestrel / Ethinyl Estradiol)
Effects of Administration of Fostamatinib on Blood Concentrations of an Oral Contraceptive in Healthy Female Subjects [Recruiting]
A crossover study to assess the effect of repeated doses of fostamatinib on the levels of
oral contraceptive (Microgynon® 30) in the blood of healthy female subjects. The study will
consist of a screening period of up to 35 days, followed by 2 treatment periods (28 days
each) of an oral contraceptive (Microgynon® 30) in the absence and presence of fostamatinib.
The study will also evaluate the safety and tolerability of fostamatinib in combination
with an oral contraceptive
AZD6140 Oral Contraceptive Interaction Study [Recruiting]
A Study to Investigate the Potential Pharmacokinetic Interaction of Perampanel With Oral Contraceptives in Healthy Female Subjects [Recruiting]
Evaluation Of The Product Cicloï¿½ 21 Pharmacodynamics (Levonorgestrel + Ethinyl Estradiol), Marketed By Uniï¿½o Quï¿½mica Farmacï¿½utica Nacional S / A, Compared To Nordetteï¿½ Product To The Lab Wyeth Pharmaceutical Industries Ltd. [Not yet recruiting]
Assessment of the pharmacodynamic profile of the drug Ciclo 21 ®, marketed by União Química
Farmacêutica Nacional S / A, compared to the drug Nordette ® Laboratory Wyeth Pharmaceutical
Ltda. Through the modulation of hormonal response (inhibition of the pituitary) evidenced by
measurement serum LH and FSH for 28 days, as well as by the absence of follicle formation
demonstrated by transvaginal ultrasound examinations
Assessment of Effects on Ovarian Activity of a Combined Oral Contraceptive Pill When Preceded by the Intake of ellaOneï¿½ or Placebo. [Recruiting]
Reports of Suspected Lybrel (Levonorgestrel / Ethinyl Estradiol) Side Effects
Weight Increased (3),
Increased Appetite (1),
Appetite Disorder (1),
Vaginal Haemorrhage (1),
Menstruation Irregular (1),
Androgen Deficiency (1),
Oestrogen Deficiency (1), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 2 ratings/reviews, Lybrel has an overall score of 4. The effectiveness score is 5 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst.
Lybrel review by 36 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Considerably Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || no more monthly periods|
|Dosage & duration:|| || 1 pill per day taken every day for the period of since Nov. 2007|
|Other conditions:|| || none|
|Other drugs taken:|| || none|
|Benefits:|| || no more monthly periods|
|Side effects:|| || slight spotting for more than 7 days each cycle|
|Comments:|| || Since Nov 2007 I have been taking Lybrel to avoid my period. According to the manufacturer it is normal to have spotting for the first 6-12 month. I had many days of spotting until this July- so for 8 month. Since this August I had no more bleeding.|
Lybrel review by 18 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Ineffective|
|Side effects:|| || Moderate Side Effects|
|Condition / reason:|| || no more period|
|Dosage & duration:|| || normal dose (dosage frequency: everydat) for the period of 9 months|
|Other conditions:|| || non-stop bleeding for 9 months no sex drive rapid weight loss|
|Other drugs taken:|| || none|
|Benefits:|| || i couldn't get pregnant|
|Side effects:|| || *
mild nausea, vomiting, bloating, stomach cramps;
breast pain, tenderness, or swelling;
freckles or darkening of facial skin;
increased hair growth, loss of scalp hair;
changes in weight or appetite;
problems with contact lenses;
vaginal itching or discharge;
changes in your menstrual periods, decreased sex drive; or
headache, nervousness, dizziness, tired feeling.
|Comments:|| || take a pill everday peferablly the same time|
Page last updated: 2014-10-20