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Lupron (Leuprolide Acetate) - Summary



Leuprolide acetate is a synthetic nonapeptide analog of naturally occurring gonadotropin releasing hormone (GnRH or LH-RH). The analog possesses greater potency than the natural hormone.

LUPRON INJECTION (leuprolide acetate) is indicated in the palliative treatment of advanced prostatic cancer.


LUPRON INJECTION is indicated in the treatment of children with central precocious puberty. Children should be selected using the following criteria:

  1. Clinical diagnosis of CPP (idiopathic or neurogenic) with onset of secondary sexual characteristics earlier than 8 years in females and 9 years in males.
  2. Clinical diagnosis should be confirmed prior to initiation of therapy:
      Confirmation of diagnosis by a pubertal response to a GnRH stimulation test. The sensitivity and methodology of this assay must be understood.
    • Bone age advanced 1 year beyond the chronological age.
  3. Baseline evaluation should also include:
      Height and weight measurements.
    • Sex steroid levels.
    • Adrenal steroid level to exclude congenital adrenal hyperplasia.
    • Beta human chorionic gonadotropin level to rule out a chorionic gonadotropin secreting tumor.
    • Pelvic/adrenal/testicular ultrasound to rule out a steroid secreting tumor.
    • Computerized tomography of the head to rule out intracranial tumor.

See all Lupron indications & dosage >>


Media Articles Related to Lupron (Leuprolide)

Are Too Many Prostate Cancer Patients Receiving Treatment?
Source: MedicineNet Cancer Specialty [2015.02.20]
Title: Are Too Many Prostate Cancer Patients Receiving Treatment?
Category: Health News
Created: 2/19/2015 12:00:00 AM
Last Editorial Review: 2/20/2015 12:00:00 AM

Study: Surveillance Is for Middle-Risk Prostate Cancer Too
Source: Medscape Hematology-Oncology Headlines [2015.02.19]
Active surveillance might be useful in 'favorable' intermediate-risk disease, American researchers say about their study of more than 5000 men.
Medscape Medical News

Alternative to Overall Survival in Prostate Cancer Trials?
Source: Medscape Hematology-Oncology Headlines [2015.02.19]
Radiographic progression-free survival correlates with overall survival in patients with metastatic castration-resistant prostate cancer.
Medscape Medical News

New study reveals how to improve chemotherapy use in prostate cancer
Source: Endocrinology News From Medical News Today [2015.02.19]
Next generation chemotherapy for prostate cancer has unique properties that could make it more effective earlier in treatment if confirmed in clinical trialsProstate cancer is the second leading...

Two major studies strengthen case for prostate cancer drug before chemotherapy
Source: Prostate / Prostate Cancer News From Medical News Today [2015.02.06]
Pioneering prostate cancer drug abiraterone significantly extends the lives of men with advanced prostate cancer if given before chemotherapy, the results of a major phase III clinical trial have...

more news >>

Published Studies Related to Lupron (Leuprolide)

A phase III extension trial with a 1-arm crossover from leuprolide to degarelix: comparison of gonadotropin-releasing hormone agonist and antagonist effect on prostate cancer. [2011.09]
PURPOSE: We investigated the efficacy and safety of degarelix treatment and the effects of switching from leuprolide to degarelix in an ongoing extension study with a median 27.5-month followup of a pivotal 1-year prostate cancer trial... CONCLUSIONS: Data support the statistically significant prostate specific antigen progression-free survival benefit for degarelix over leuprolide seen during year 1 and the use of degarelix as first line androgen deprivation therapy as an alternative to a gonadotropin-releasing hormone agonist. Copyright (c) 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

A randomized trial of microdose leuprolide acetate protocol versus luteal phase ganirelix protocol in predicted poor responders. [2011.06.30]
We performed a randomized trial to compare IVF outcomes in 54 poor responder patients undergoing a microdose leuprolide acetate (LA) protocol or a GnRH antagonist protocol incorporating a luteal phase E(2) patch and GnRH antagonist in the preceding menstrual cycle.

Hot flushes in prostatic cancer patients during androgen-deprivation therapy with monthly dose of degarelix or leuprolide. [2011.06]
The aim of the study was to compare the onset, incidence and frequency/intensity of hot flushes during androgen-deprivation therapy with a gonadotropin-releasing hormone antagonist (GnRH) blocker versus an agonist using data from a randomized Phase 3 clinical trial...

Randomized trial of leuprolide versus continuous oral contraceptives in the treatment of endometriosis-associated pelvic pain. [2011.04]
OBJECTIVE: To compare the efficacy of leuprolide and continuous oral contraceptives in the treatment of endometriosis-associated pain...

Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trial. [2010.11]
OBJECTIVE: To determine whether insulin sensitizers lower androgen levels and whether androgen suppression improves insulin resistance in nondiabetic postmenopausal women... They confirm that treatment of insulin resistance decreases T production in this population and demonstrate that pharmacologic lowering of T does not affect insulin resistance.

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Clinical Trials Related to Lupron (Leuprolide)

Pharmacodynamics of Lorelin Depot (Leuprorelin Acetate - Bergamo) Compared to Lupron Depot � (Leuprorelin Acetate - Abbot) [Recruiting]
The primary objective of this study is to examine, in healthy subjects, the comparative pharmacodynamics of Lorelin Depot (leuprorelin), manufactured by the Chemical Pharmaceutical Laboratory Bergamo Ltda with the product Lupron Depot ® (leuprorelin), manufactured by Abbott Laboratories Ltd, through the strength of biological markers follicle stimulating hormone (FSH), luteinizing hormone (LH) and total testosterone, associated with the activity of the substance.

Secondarily be observed safety (tolerability) of subjects in clinical research through the comparison of clinical and laboratory parameters pre-and post-study, and incidence of adverse events.

Neoadjuvant Abiraterone Acetate Plus Leuprolide Acetate in Men With Localized High Risk Prostate Cancer [Recruiting]
The purpose of this research study is to determine the effects of abiraterone acetate plus leuprolide acetate and prednisone versus leuprolide acetate alone on hormone levels in the blood and prostate. For this study, patients are required to be suitable candidates for a radical prostatectomy (prostate surgery) which will be performed after 24 weeks of treatment.

Treatment of Endometriosis With Norethindrone Acetate ( NA) VS. Gonadotropin- Releasing Hormone (GnRH) Agonist (Lupron Depot 11.25 mg) [Recruiting]
(A) Major 1) to compare the effectiveness of norethindrone acetate (NA) with GnRH agonist (Lupron-Depot-3) in relieving symptoms of endometriosis, 2) to compare bone density in the two treated groups in order to demonstrate that NA does not affect bone density; (B) Minor: 1) To compare the lipid profiles of patients in the two groups to confirm the hypothesis that the effects of NA and GnRH agonists on lipid profiles are similar, 2) To determine whether quality of life, assessed by questionnaire, is better in patients assigned to NA than in patients assigned to GnRH, 3) To determine whether NA has fewer adverse effects than GnRH agonist.

Initiation of Androgen Deprivation Therapy for Prostate Cancer Using Degarelix Followed by Leuprolide [Recruiting]
The purpose of this study is to determine if patients initiating androgen deprivation therapy (ADT) for prostate cancer can be transitioned from degarelix acetate to leuprolide acetate after an initial three-month period without a rise in serum testosterone. The investigators expect testosterone will quickly and reliably reach castrate levels after initiation of ADT and will remain castrate during the transition, and there will be no "testosterone surge" after leuprolide injection.

Ipilimumab + Androgen Deprivation Therapy in Prostate Cancer [Recruiting]
The goal of this clinical research study is to learn if ipilimumab in combination with either Lupron® (leuprolide), Zoladex® (goserelin), or Firmagon® (degarelix) can affect prostate-specific antigen (PSA) levels in patients with prostate cancer. Researchers also want to learn if these drug combinations affect the body's immune system. The safety of these drug combinations will also be studied.

more trials >>

Reports of Suspected Lupron (Leuprolide) Side Effects

Headache (21)Fatigue (14)Hot Flush (12)Pain (9)Night Sweats (8)Abortion Spontaneous (8)Back Pain (8)Dyspnoea (8)Arthralgia (8)Bone Pain (7)more >>


Based on a total of 2 ratings/reviews, Lupron has an overall score of 5. The effectiveness score is 8 and the side effect score is 5. The scores are on ten point scale: 10 - best, 1 - worst.

Lupron review by 54 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   uterine fibroids/heavy bleeding
Dosage & duration:   one injection once a month (dosage frequency: once a month) for the period of 6 months
Other conditions:   anemia
Other drugs taken:   iron
Reported Results
Benefits:   The drug stopped my menstrual periods and put me into artificial menopause. The hope was that it would trigger my body to go into menpause and stop the heavy bleeding associated with my fibroids. Unfortunately, my period came back approximately 2 months after the last injection
Side effects:   Hot flashes, night sweats and vaginal dryness.
Comments:   I was injected once a month subcutaneously in my abdomen just below the belly button.


Lupron review by 40 year old female patient

Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   Endometriosis
Dosage & duration:   1 syringe (dosage frequency: once a month) for the period of 3 months
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   The Lupron suppressed the growth of the Endometriosis on my urethas.
Side effects:   I experienced memory loss.
Comments:   Received one shot during each visit once a month. Then after the third shot started having severe memory loss. Could not remember where I was driving to while in my car, could not remember where I lived etc.

See all Lupron reviews / ratings >>

Page last updated: 2015-02-20

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