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Lunesta (Eszopiclone) - Summary

 
 



LUNESTA SUMMARY

LUNESTA (eszopiclone) is a nonbenzodiazepine hypnotic agent that is a pyrrolopyrazine derivative of the cyclopyrrolone class.

LUNESTA is indicated for the treatment of insomnia. In controlled outpatient and sleep laboratory studies, LUNESTA administered at bedtime decreased sleep latency and improved sleep maintenance.

The clinical trials performed in support of efficacy were up to 6 months in duration. The final formal assessments of sleep latency and maintenance were performed at 4 weeks in the 6-week study (adults only), at the end of both 2-week studies (elderly only) and at the end of the 6-month study (adults only).


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NEWS HIGHLIGHTS

Media Articles Related to Lunesta (Eszopiclone)

Insomnia Quiz: What Is Insomnia?
Source: MedicineNet Sleep Specialty [2017.09.19]
Title: Insomnia Quiz: What Is Insomnia?
Category: MedicineNet Quiz
Created: 6/6/2016 12:00:00 AM
Last Editorial Review: 9/19/2017 6:44:12 PM

20 Tips to Beat Insomnia and Sleep Better
Source: MedicineNet Sleep Aids And Stimulants Specialty [2017.07.26]
Title: 20 Tips to Beat Insomnia and Sleep Better
Category: Slideshows
Created: 10/1/2014 12:00:00 AM
Last Editorial Review: 7/26/2017 12:00:00 AM

Insomnia
Source: MedicineNet Hyperthyroidism Specialty [2017.05.12]
Title: Insomnia
Category: Symptoms and Signs
Created: 7/28/2006 12:00:00 AM
Last Editorial Review: 5/12/2017 12:00:00 AM

Insomnia (Symptoms, Causes, Remedies, and Cures)
Source: MedicineNet Biorhythms Specialty [2017.04.19]
Title: Insomnia (Symptoms, Causes, Remedies, and Cures)
Category: Diseases and Conditions
Created: 6/6/2005 12:00:00 AM
Last Editorial Review: 4/19/2017 12:00:00 AM

Sleep Disorders: Insomnia, Sleep Apnea, and More
Source: MedicineNet modafinil Specialty [2016.08.22]
Title: Sleep Disorders: Insomnia, Sleep Apnea, and More
Category: Slideshows
Created: 7/23/2010 2:39:00 PM
Last Editorial Review: 8/22/2016 12:00:00 AM

more news >>

Published Studies Related to Lunesta (Eszopiclone)

A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in patients with chronic low back pain. [2014]
therapy to pain-targeted treatment might improve sleep and pain in LBP... CONCLUSIONS: The addition of insomnia-specific therapy to a standardized naproxen

Eszopiclone for insomnia associated with attention-deficit/hyperactivity disorder. [2014]
attention-deficit/hyperactivity disorder (ADHD)... CONCLUSIONS: Eszopiclone (up to 3 mg) failed to reduce latency to persistent

Effect of eszopiclone on sleep, fatigue, and pain in patients with mucositis associated with hematologic malignancies. [2011.12]
PURPOSE: Patients with malignancy sometimes develop painful mucositis and require patient-controlled analgesia (PCA) to treat their pain. Pain disrupts sleep and there is some evidence that analgesic medications also disrupt sleep. This study examined whether treatment with the sedative hypnotic eszopiclone could improve self-reports of sleep, fatigue, and pain as well as decrease opioid self-administered via PCA... CONCLUSION: Sedative hypnotic agents improve sleep and analgesia even in the setting of considerable pain and discomfort.

Eszopiclone for the treatment of posttraumatic stress disorder and associated insomnia: a randomized, double-blind, placebo-controlled trial. [2011.07]
CONCLUSIONS: This study provides initial evidence that pharmacotherapy with eszopiclone may be associated with short-term improvement in overall PTSD severity as well as associated sleep disturbance. Longer, more definitive study of eszopiclone in PTSD is warranted. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00120250. (c) Copyright 2011 Physicians Postgraduate Press, Inc.

A post hoc analysis of the effect of nightly administration of eszopiclone and a selective serotonin reuptake inhibitor in patients with insomnia and anxious depression. [2011.04]
CONCLUSIONS: In this post hoc analysis of patients with insomnia and comorbid anxious depression derived from 2 trials, 8 weeks of eszopiclone therapy coadministered with an SSRI resulted in significantly greater improvements in insomnia, significantly greater reductions in HDRS-17 total score, and significantly greater HDRS-17 response rates compared with placebo coadministration. There were no significant differences in response rates (when insomnia items were excluded) and remission rates, as well as in anxiety/somatization scores. Further research is warranted to determine whether these modest antidepressant effects can be replicated, and anxiolytic effects demonstrated, when evaluated in a prospective manner. (c) Copyright 2011 Physicians Postgraduate Press, Inc.

more studies >>

Clinical Trials Related to Lunesta (Eszopiclone)

The Effects of Eszopiclone and Lexapro on Prefrontal Glutamate and GABA in Depression With Anxiety and Insomnia [Completed]
The study examined the effects of adding the sleep aid eszopiclone to Lexapro on mood and levels of the neurotransmitters glutamate, glutamine, and GABA in women with depression, anxiety, and insomnia. Specifically, the objective was to determine the role of glutamate, glutamine, and GABA in mediating the response the to the combined treatment. The hypothesis was that levels of glutamine and glutamate will be increased in women receiving eszopiclone compared to those receiving placebo. The antidepressant effect of the medication combination and its effect on sleep status was also assessed.

Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban [Terminated]
Objectives: The primary objective of this study is to determine the efficacy of eszopiclone at treating sleep problems related to withdrawal from nicotine in healthy smokers attempting smoking cessation. Sleep disturbances are a significant problem for smokers who are trying to quit smoking. Smokers may be more likely to have sleep problems and both nicotine withdrawal and agents used to aid smoking cessation (e. g., pharmacotherapies) may disrupt sleep. Lunesta (eszopiclone) is a medication that has been approved by the FDA to treat insomnia. Eszopiclone's efficacy for treating insomnia makes it a promising agent for treating nicotine withdrawal-related symptoms of sleep disturbance. This study will be 7 weeks duration. All participants will begin taking Zyban at the beginning of week 1 and will be asked to try to quit smoking at the beginning of week 2. Participants will also begin to take Lunesta or matched placebo (3 mg qd x 6 weeks) on the target quit date at the beginning of week 2. All subjects will receive eight (8) weekly sessions of brief individual supportive smoking cessation counseling. Hypothesis: It is hypothesized that significantly fewer sleep problems will be reported by participants taking Lunesta as compared to placebo. Specifically, it is expected that participants taking Lunesta will report less difficulty falling and staying asleep, higher sleep quality, and less insomnia-related fatigue and distress than participants taking placebo.

Efficacy & Safety of Eszopiclone (Lunesta) in Nursing Home Patients [Completed]
The purpose of this study is to examine the effects of the sleep aid Lunesta (Eszopiclone), on older adults who reside in a nursing home and have poor sleep as determined by wrist actigraphy.

Eszopiclone for Sleep Disturbance and Nightmares in Post-Traumatic Stress Disorder [Completed]
The purpose of this study is to obtain data investigating the safety and efficacy of eszopiclone for the treatment of post-traumatic stress disorder (PTSD)-related sleep disturbance and the impact of improved sleep with eszopiclone treatment on neuroendocrine correlates of PTSD. The investigators hypothesize that eszopiclone will be significantly more effective than placebo and well tolerated for PTSD-related sleep disturbance, improvement in sleep will be associated with improvement in overall PTSD symptoms, and patients with PTSD-related sleep disturbances will have abnormal levels of stress hormones.

Treatment of Insomnia in Patients With Parkinson's Disease: A Multi-site, Placebo-controlled Study of Eszopiclone [Completed]
Parkinson's disease (PD) is the second most common neurodegenerative disease in the US, affecting nearly 1 million Americans. Up to 82% of community dwelling individuals with PD complain of sleep disturbances, typically sleep fragmentation. Despite the high prevalence of sleep problems and their impact on the life of these individuals, there has been, until recently, little research focus on the problem. This will be a multi-site, double blind, placebo-controlled, two arm, parallel group, fixed-dose trial which will last 6 weeks. Seventy patients at four sites (30 at the PI's site and a total of 40 patients at three external sites) will be equally randomized to eszopiclone or placebo. The primary hypothesis is that eszopiclone will be superior to placebo for the treatment of insomnia in patients with Parkinson's disease

more trials >>

Reports of Suspected Lunesta (Eszopiclone) Side Effects

Drug Ineffective (16)Insomnia (15)Somnolence (7)Agitation (6)Fatigue (6)Depression (6)Anxiety (6)Middle Insomnia (6)Somnambulism (6)Confusional State (5)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 19 ratings/reviews, Lunesta has an overall score of 5.74. The effectiveness score is 7.16 and the side effect score is 7.16. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Lunesta review by 52 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   insomnia
Dosage & duration:   5mg taken every night for the period of 1 yr
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   I have trouble sleeping -- I usually toss and turn all night, sleep a couple of hours and wake up. Normally, I never get a complete night's rest. After my doctor prescribed Lunesta, it was the first time in a very long time, that I was able to sleep from the time I laid my head on the pillow until my alarm sounded in the morning.
Side effects:   I had no side effects from using Lunesta. I felt refreshed in the morning without that groggy feeling or "hang over" like feeling.
Comments:   The treatment involved taking one pill in the evening right before bed. Lunesta works relatively fast, so you do not want to take it unless you are going right to bed because you become drowsy within 10 minutes.

 

Lunesta review by 41 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   insomnia
Dosage & duration:   3 mg taken every night for the period of 1 year
Other conditions:   anxiety
Other drugs taken:   none
  
Reported Results
Benefits:   Lunesta definitely put me to sleep and kept me asleep until morning.
Side effects:   There was a hangover from the medication well into the morning hours after waking.
Comments:   For years I had suffered with insomnia until my doctor prescribed Lunesta in a 3mg dose. It worked very well putting me to sleep and I did not wake until morning. Unfortunately I could sleep 10 - 12 hours and still wake up with a hangover from the medicine. Sometimes a half of a pill would do but I would still have somewhat of a hangover although not as bad. Now I only take during times of stress when sleeping is more important than any of the side effects.

 

Lunesta review by 33 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Insomina
Dosage & duration:   3mg taken 1 daily for the period of 1 day
Other conditions:   Alpha 1 Antitrpsin Disorder
Other drugs taken:   Prolastin
  
Reported Results
Benefits:   NONE
Side effects:   HORRIABLE taste in mouth with 15 minutes of taking it. Even breathing tasted bad as when the air hit my mouth and airway the taste was intensified. I tried to drink water to get rid of the taste and promptly threw up the taste was so bad. Within half an hour of taking the pill I developed a red rash on my face, and in an hour had a full blown lights and floaties migraine. To top it all of my insomonia was actually MADE worse. Two hours after taking the pill I am more awake and alert then I was BEFORE taking it.
Comments:   This is by far the worst medication I have ever taken. I got no help, in fact the problem got much worse and the side effects were unbearable!

See all Lunesta reviews / ratings >>

Page last updated: 2017-09-19

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