Lumigan (Bimatoprost) - Summary

LUMIGAN SUMMARY

LUMIGAN^®
(bimatoprost ophthalmic solution) 0.03%

LUMIGAN^® (bimatoprost ophthalmic solution) 0.03% is a synthetic prostamide analog with ocular hypotensive activity.

LUMIGAN^® (bimatoprost ophthalmic solution) 0.03% is indicated for the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.

See all Lumigan indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Lumigan (Bimatoprost)

Eyelash growth in subjects treated with bimatoprost: a multicenter, randomized, double-masked, vehicle-controlled, parallel-group study. [2012]
topical administration to upper eyelid margins... CONCLUSION: Bimatoprost 0.03% was found to be effective at enhancing eyelashes in

Twenty-four-hour intraocular pressure control with latanoprost-timolol-fixed combination versus bimatoprost in patients who switched from timolol. [2011.10]
PURPOSE: To evaluate bimatoprost versus latanoprost and timolol fixed combination (LTFC) over the 24-hour diurnal curve in patients who switched from timolol... CONCLUSIONS: The LTFC and bimatoprost therapies were equally effective in maintaining IOP at lower levels during the 24-hour period in patients who switched from timolol therapy. Adverse events were more frequent with bimatoprost therapy.

Eyelash growth in subjects treated with bimatoprost: A multicenter, randomized, double-masked, vehicle-controlled, parallel-group study. [2011.09.05]
BACKGROUND: Bimatoprost 0.03% is associated with increased growth and prominence of eyelashes. OBJECTIVE: We sought to compare the safety and efficacy of once-daily bimatoprost 0.03% versus vehicle in increasing eyelash length, thickness, and darkness after topical administration to upper eyelid margins... CONCLUSION: Bimatoprost 0.03% was found to be effective at enhancing eyelashes in adults with a very good safety profile. Copyright (c) 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

The comparison of the effects of latanoprost, travoprost, and bimatoprost on central corneal thickness. [2011.08]
PURPOSE: To compare the effects of latanoprost, travoprost, and bimatoprost on central corneal thickness (CCT)... CONCLUSIONS: Topical therapy with prostaglandin analogues is associated with CCT reduction. Latanoprost, travoprost, and bimatoprost have a similar effect on CCT.

Twenty-four-hour intraocular pressure control with latanoprost-timolol-fixed combination versus bimatoprost in patients who switched from timolol. [2011]
(LTFC) over the 24-hour diurnal curve in patients who switched from timolol... CONCLUSIONS: The LTFC and bimatoprost therapies were equally effective in

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Clinical Trials Related to Lumigan (Bimatoprost)

Intraocular Pressure Reduction With the Bimatoprost/Timolol Fixed Combination [Recruiting]
The purpose of this study is to examine the ocular hypotensive effect of Bimatoprost and the potential additional effect of the Bimatoprost/Timolol fixed combination in eyes with ocular hypertension, primary open angle glaucoma or exfoliation glaucoma.

Latisse (Bimatoprost .03% Opthalmic Solution) for the Treatment of Hypotrichosis of the Eyebrows: Latisse Versus Placebo [Recruiting]
The primary purpose of this study is to assess efficacy and safety of Latisse (bimatoprost .03% ophthalmic solution) applied to the lateral and medial eyebrows. The primary outcome is a increase in overall eyebrow prominence as measured by at least a 1-grade increase on the Global Eyebrow Assessment (GEyA) scale, from baseline to the end of the treatment which will be day 270 period.

The Effects of Xalatan, Travatan and Lumigan on Skin Pigmentation Near the Eye [Recruiting]

Efficacy Study of Latanoprost and Bimatoprost Solutions in Promoting Eyelash Growth in Patients With Alopecia Areata [Active, not recruiting]
This is a single center, randomized, investigator-masked study to determine the efficacy and safety of latanaprost and bimatoprost ophthalmic solutions in promoting eyelash growth in patients who have lost their eyelashes due to alopecia areata. These medications are FDA-approved as eyedrops for patients with glaucoma who have been noted to grow longer, darker, and thicker eyelashes with their use. In this study, patients will be asked to apply these solutions to the affected eyelid margins of one eye with a sterile cotton-tipped applicator once a day.

Safety and Efficacy Study of Different Formulations of Bimatoprost Once-Daily in Patients With Glaucoma or Ocular Hypertension [Completed]
This study evaluates the safety and efficacy of different formulations of bimatoprost ophthalmic solution compared with Bimatoprost 0. 03% once-daily in patients with glaucoma or ocular hypertension. One of the test formulations was given to one eye and bimatoprost 0. 03% given to the fellow eye of each patient

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Reports of Suspected Lumigan (Bimatoprost) Side Effects

Ocular Hyperaemia (61),  Eye Irritation (60),  Eye Pain (40),  Headache (29),  Drug Ineffective (24),  Growth of Eyelashes (24),  Eye Pruritus (24),  Intraocular Pressure Increased (23),  Vision Blurred (23),  Visual Acuity Reduced (18), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Lumigan review by 35 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		o increase length and fullness of eyelashes
Dosage & duration:		Apply to eyelashes (dosage frequency: once per day) for the period of Four months
Other conditions:		N/A
Other drugs taken:		N/A
		Reported Results
Benefits:		My eyelashes grew extremely long.
Side effects:		If I got any of the product on my eyelids, it stained them purple.
Comments:		This was prescribed off-label to me. It is a potent glaucoma drug. It is essential that you not get it in your eyes or on your eyelids. It only needs to be painted on the eyelashes, away from the eyelids, to be effective. Results were seen within a month.

Lumigan review by 49 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Longer eyelashes
Dosage & duration:		once thin strip on eyelashes nightly (dosage frequency: once a night) for the period of 3 months
Other conditions:		itchy eyelids
Other drugs taken:		only vitamins
		Reported Results
Benefits:		The Lumigan made my lashes grown longer and thicker. I didn't need to use as much mascara.
Side effects:		I got itchy eyelids. The itching was fairly mild.
Comments:		I put a drop of lumigan on an upside down teacup. Then I applied lumigan with a very fine artists type paintbrush. I would paint a thin line just above the lashes on top and just below the lashes on bottom. I would then use the remainder on my eyebrows. After about 6 weeks I noticed my lashes were longer and thicker. I washed the paintbrush carefully after each use and was careful to keep the line thin. After the first week, I began to use it every other night.

Lumigan review by 34 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		Eyelash growth
Dosage & duration:		One or two drops along the lash line (dosage frequency: once a day) for the period of One month
Other conditions:		None
Other drugs taken:		Birth Control pills
		Reported Results
Benefits:		The upper and lower eyelashes grew longer, thicker, and darker. There is less need for mascara or eyelash curlers with this product. Lumigan contains the same active ingredient that Latisse will contain when it is released but the difference is that Lumigan is prescribed as a glaucoma medication while Latisse will be marketed and sold as an eyelash growth product. It does work.
Side effects:		I developed dark under eye circles, itching, redness and a slight headache after each use but I was told that the under eye circles and headaches I experienced were less common side effects. Once the treatment was stopped all of the side effects disappeared including the dark under eye circles. Also, once the treatment is stopped the eyelashes eventually return to their original state.
Comments:		I was told to use it once a day at night and to apply it with clean brush. It is important to try to keep the bottle from having direct contact with the skin in order to avoid contamination. I used a new eyelash brush daily and Latisse contains once a day applicators.