LOXITANE SUMMARY
LOXITANE, loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines.
LOXITANE is indicated for the treatment of schizophrenia. The efficacy of LOXITANE in schizophrenia was established in clinical studies which enrolled newly hospitalized and chronically hospitalized acutely ill schizophrenic patients as subjects.
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NEWS HIGHLIGHTS
Published Studies Related to Loxitane (Loxapine)
Aggression in the demented patient: a double-blind study of loxapine versus haloperidol. [1993.06]
Aggression is common in dementia, with devastating social consequences. While high or low potency neuroleptics are the usual treatment of choice, they have been shown to yield inconsistent behavioral improvement and significant iatrogenic disability...
The role of metabolites in a bioequivalence study 1: loxapine, 7-hydroxyloxapine and 8-hydroxyloxapine. [1993.04]
Loxapine is a drug which is used in the treatment of psychotic disorders. The drug is extensively biotransformed in humans to produce a variety of metabolites, some of which have pharmacological activity.In fact, the within-subject variabilities of the metabolites were relatively low, so that the 90% confidence intervals for ln AUC0 infinity, ln AUC0t and ln Cmax calculated for the metabolites, were narrower that those for the parent drug.(ABSTRACT TRUNCATED AT 250 WORDS).
Loxapine for schizophrenia. [2007.10.17]
CONCLUSIONS: Loxapine is an antipsychotic which is not clearly distinct from typical or atypical drugs in terms of its effects on global or mental state. Loxapines profile of adverse effects is similar to that of the older generation of antipsychotic drugs.
Effect of loxapine on electrical brain activity, intracranial pressure, and middle cerebral artery flow velocity in traumatic brain-injured patients. [2007]
INTRODUCTION: Delirium is a frequent complication of traumatic brain injury, especially during the weaning period. Antipsychotic drugs are often used in this case. Loxapine is a tricyclic antipsychotic drug with sedating properties. The effects of intravenous loxapine on EEG as well as on systemic and cerebral hemodynamics after traumatic brain injury are unknown... CONCLUSION: 10 mg of loxapine administered intravenously over 10 min decreased brain electrical activity. There is a concomitant reduction in ICP without any significant change in cerebral blood flow velocity. The use of intravenous loxapine to control agitation is not accompanied by deleterious hemodynamic or systemic effects in ICU's traumatic brain injured patients.
Effect of loxapine on peripheral dopamine-like and serotonin receptors in patients with schizophrenia. [2003.01]
OBJECTIVE: To investigate the effect of loxapine on peripheral dopamine D2-like and serotonin receptor binding and on psychotic symptoms. PATIENTS: Patients (n = 24) meeting the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, for schizophrenia were selected from an outpatient clinic (age range 18-70 yr)... CONCLUSION: Loxapine down-regulated both lymphocyte D2-like and platelet 5-HT2A receptors to the same extent, suggesting that both receptors are involved in the mechanism of action of loxapine in patients with schizophrenia.
Clinical Trials Related to Loxitane (Loxapine)
StaccatoŽ Loxapine Treatment of Agitation in Bipolar Disorder Patients [Recruiting]
Randomized Double-Blind Trial of Midazolam and Loxapine in Agitated Patients [Recruiting]
Neuroleptics are used since a long time in the management of severely agitated patients.
Loxapine is routinely used in our country, with, to our knowledge no severe adverse event
reported, in this indication.
However, recently, benzodiazepines have appeared interesting in agitated patients, with the
use of midazolam.
The aim of this study is to compare midazolam to loxapine in the treatment of severe
agitated patients admitted in the emergency department.
Staccato Loxapine for Outpatient Migraine [Recruiting]
Assess the safety and efficacy of Staccato Loxapine in patients with moderate to severe
migraine headache with or without aura in an outpatient setting.
Pulmonary Safety of Staccato LoxapineŽ in Healthy Volunteers [Recruiting]
The objective of this trial is to assess the pulmonary safety of 2 inhaled doses of Staccato
Loxapine within a day.
Haloperidol vs Olanzapine for the Management of ICU Delirium [Recruiting]
The purpose of this randomized clinical trial is to determine whether haloperidol is
superior to olanzapine for the treatment of ICU acquired delirium. The hypothesis is that
haloperidol is in fact superior to olanzapine in treating ICU acquired delirium and
sustaining delirium free time.
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