WARNING: FETAL TOXICITY
When pregnancy is detected, discontinue Lotrel as soon as possible (5.4). Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus (5.4)
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LOTREL SUMMARY
Lotrel is a combination of amlodipine besylate and benazepril hydrochloride.
Hypertension
Lotrel is indicated for the treatment of hypertension in patients not adequately controlled on monotherapy with either agent. Â
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NEWS HIGHLIGHTSMedia Articles Related to Lotrel (Amlodipine / Benazepril)
High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes Source: MedicineNet Facial Nerve Problems Specialty [2017.09.19] Title: High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes Category: MedicineNet Quiz Created: 2/9/2011 12:00:00 AM Last Editorial Review: 9/19/2017 6:02:11 PM
Pulmonary Hypertension (Symptoms, Treatment Medications, Life Expectancy) Source: MedicineNet Congenital Heart Disease Specialty [2017.07.26] Title: Pulmonary Hypertension (Symptoms, Treatment Medications, Life Expectancy) Category: Diseases and Conditions Created: 12/31/1997 12:00:00 AM Last Editorial Review: 7/26/2017 12:00:00 AM
High Blood Pressure (Hypertension) Source: MedicineNet Polycystic Ovary Specialty [2017.03.31] Title: High Blood Pressure (Hypertension) Category: Symptoms and Signs Created: 1/15/2014 12:00:00 AM Last Editorial Review: 3/31/2017 12:00:00 AM
Portal Hypertension Source: MedicineNet nitroglycerin Specialty [2016.09.06] Title: Portal Hypertension Category: Diseases and Conditions Created: 1/31/2005 12:00:00 AM Last Editorial Review: 9/6/2016 12:00:00 AM
Picture of Hypertension Source: MedicineNet betaxolol ophthalmic Specialty [2014.12.09] Title: Picture of Hypertension Category: Images Created: 2/3/2011 12:00:00 AM Last Editorial Review: 12/9/2014 12:00:00 AM
Published Studies Related to Lotrel (Amlodipine / Benazepril)
Comparative efficacy and safety of amlodipine/benazepril combination therapy and amlodipine monotherapy in severe hypertension. [2010.06] This multicentre, double-blind, trial in subjects with severe hypertension compared the efficacy and tolerability of two parallel drug regimens: A/B (amlodipine/benazepril: 5/20 or 10/40 mg daily, if necessary) with A (amlodipine: 5 or 10 mg daily, if necessary)... We conclude that titration of amlodipine and benazepril in single-pill combinations is more effective than titration of amlodipine alone for rapid BP control in patients with severe hypertension.
An eight-week, multicenter, randomized, double-blind study to evaluate the efficacy and tolerability of fixed-dose amlodipine/benazepril combination in comparison with amlodipine as first-line therapy in chinese patients with mild to moderate hypertension. [2008.06] CONCLUSIONS: In this group of patients, comparable antihypertensive effects were seen with the fixed-dose combination therapy, compared with amlodipine monotherapy. Both treatments appeared well tolerated in the studied population, but cough was more common in the fixed-dose combination group.
The effects of high-dose amlodipine/benazepril combination therapies on blood pressure reduction in patients not adequately controlled with amlodipine monotherapy. [2007.03] BACKGROUND: This study compared the efficacy and safety of amlodipine/benazepril (10/40 mg/day and 10/20 mg/day) with amlodipine 10 mg/day in patients whose blood pressure (BP) was not adequately controlled with amlodipine monotherapy... CONCLUSION: Amlodipine/benazepril combinations were well tolerated and resulted in significant BP reductions and better BP responder rates than amlodipine monotherapy.
Efficacy of combination therapy with amlodipine besylate/benazepril hydrochloride for lowering systolic blood pressure in stage 2 hypertension. [2006.05] The Systolic Evaluation of Lotrel Efficacy and Comparative Therapies (SELECT) study compared daily treatment with combination amlodipine besylate/benazepril hydrochloride 5/20 mg, amlodipine besylate 5 mg, and benazepril hydrochloride 20 mg in 505 patients aged 55 years of age or older with stage 2 hypertension (systolic blood pressure [BP] > or =160 and < or =200 mm Hg and diastolic BP > or =60 and < or =100 mm Hg)...
Efficacy of combination therapy for systolic blood pressure in patients with severe systolic hypertension: the Systolic Evaluation of Lotrel Efficacy and Comparative Therapies (SELECT) study. [2005.11] Systolic hypertension is predominant among patients over 50 years of age, is a more important cardiovascular risk factor than diastolic blood pressure, and is more difficult to control than diastolic blood pressure. Consequently, the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) recommends combination therapy as first-line treatment for patients with stage 2 hypertension...
Clinical Trials Related to Lotrel (Amlodipine / Benazepril)
Amlodipine-Benazepril 10mg-20mg Capsules in Healthy Subjects Under Fed Conditions [Completed]
Amlodipine-Benazepril 10mg-20mg Capsules in Healthy Subjects Under Fasting Conditions [Completed]
Bioequivalence Study of 10 mg Amlodipine Besylate/ 20 mg Benazepril Hydrochloride Capsules of Dr.Reddys Laboratories Limited Under Fasting Conditions [Completed]
The objective of this study was to compare the single-dose relative bioavailability of Dr.
Reddy's Laboratories, Ltd. and Lotrel®) 10 mg amlodipine besylate/20 mg benazepril
hydrochloride capsules, under fasting conditions.
Bioequivalence Study of 10 mg Amlodipine Besylate/ 20 mg Benazepril Hydrochloride Capsules of Dr.Reddys Laboratories Limited Under Non-fasting (Fed) Conditions [Completed]
The objective of this study was to compare the single-dose relative bioavailability of Dr.
Reddy's Laboratories, Ltd. and Lotrel®) 10 mg amlodipine besylate/20 mg benazepril
hydrochloride capsules, under non-fasting (fed) conditions.
Bioequivalence Study of Amlodipine Besylate/Benazepril HCl 10 mg/40 mg Capsules of Dr. Reddy's Under Fed Conditions [Completed]
The purpose of this study single dose bioequivalence of Amlodipine Besylate/Benazepril HCl
10 mg/40 mg capsules with Lotrel® capsules in healthy human subjects and monitor clinical
status, adverse events and laboratory investigations and assess relative safety and
tolerance under fed conditions.
Reports of Suspected Lotrel (Amlodipine / Benazepril) Side Effects
Drug Ineffective (5),
Blood Pressure Increased (5),
Headache (4),
Dizziness (4),
Cough (4),
Rash (4),
LIP Swelling (3),
Urticaria (3),
Drug Hypersensitivity (3),
Cerebrovascular Accident (3), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 3 ratings/reviews, Lotrel has an overall score of 7.67. The effectiveness score is 9.33 and the side effect score is 6.67. The scores are on ten point scale: 10 - best, 1 - worst.
| Lotrel review by 57 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Highly Effective |
Side effects: | | Mild Side Effects | | Treatment Info |
Condition / reason: | | blood pressure |
Dosage & duration: | | 10/20 (dosage frequency: every nite) for the period of 2 years |
Other conditions: | | hepatitis c |
Other drugs taken: | | none | | Reported Results |
Benefits: | | blodd pressure remained in the low area |
Side effects: | | drowsiness, loss of libido |
Comments: | | once a day |
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| Lotrel review by 45 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Considerably Effective |
Side effects: | | Severe Side Effects | | Treatment Info |
Condition / reason: | | High Blood Pressure |
Dosage & duration: | | 5mg./10mg taken 1 x daily for the period of 30 days |
Other conditions: | | Celiac Disease |
Other drugs taken: | | Trazadone | | Reported Results |
Benefits: | | I have slightly high blood pressure on the diastolic side. Lotrel did a good job at maintaining good levels without increasing my pulse which I experienced with other BP meds. |
Side effects: | | After introducing Lotrel within two weeks I notices small red dots appear on my ankles which I thought was just a heat rash. I developed Petechiae which is the bleeding of small capillaries in the skin or mucous membrane. It appears as round pinpoint sized dots that vary in colour from red to blue or purple. These dots most commonly appear on the legs but can appear all over the body. Also an onset on Acne developed on my back at about the same time which was quite severe, and I have never had Acne related problems, even in my youth.
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Comments: | | Currently my physician has taken me off of my BP meds to allow the Petechiae to fade, and to ensure that the reaction was indeed related to the Lotrel. It has been 4 days and slowly the rash and redness is mellowing. |
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| Lotrel review by 45 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Considerably Effective |
Side effects: | | Severe Side Effects | | Treatment Info |
Condition / reason: | | High Blood Pressure |
Dosage & duration: | | 5mg./10mg taken 1 x daily for the period of 30 days |
Other conditions: | | Celiac Disease |
Other drugs taken: | | Trazadone | | Reported Results |
Benefits: | | I have slightly high blood pressure on the diastolic side. Lotrel did a good job at maintaining good levels without increasing my pulse which I experienced with other BP meds. |
Side effects: | | After introducing Lotrel within two weeks I notices small red dots appear on my ankles which I thought was just a heat rash. I developed Petechiae which is the bleeding of small capillaries in the skin or mucous membrane. It appears as round pinpoint sized dots that vary in colour from red to blue or purple. These dots most commonly appear on the legs but can appear all over the body. Also an onset on Acne developed on my back at about the same time which was quite severe, and I have never had Acne related problems, even in my youth.
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Comments: | | Currently my physician has taken me off of my BP meds to allow the Petechiae to fade, and to ensure that the reaction was indeed related to the Lotrel. It has been 4 days and slowly the rash and redness is mellowing. |
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Page last updated: 2017-09-19
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