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Lotrel (Amlodipine Besylate / Benazepril Hydrochloride) - Summary

 
 



WARNING: FETAL TOXICITY

When pregnancy is detected, discontinue Lotrel as soon as possible (5.4). Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus (5.4)

 

LOTREL SUMMARY

Lotrel is a combination of amlodipine besylate and benazepril hydrochloride.

Hypertension

Lotrel is indicated for the treatment of hypertension in patients not adequately controlled on monotherapy with either agent.  


See all Lotrel indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Lotrel (Amlodipine / Benazepril)

ESC: Coffee, Naps, and Depression in Hypertension (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2015.08.29]
(MedPage Today) -- Observations support naps but suggest risk with espresso and depression

Medical News Today: Could hypertension during pregnancy signal elevated risk for siblings?
Source: Featured Health News from Medical News Today [2015.08.28]
The male siblings of women who have high blood pressure during pregnancy are at an increased risk of developing cardiovascular disease in later life, a new study finds.

Could hypertension during pregnancy signal elevated risk for siblings?
Source: Biology / Biochemistry News From Medical News Today [2015.08.28]
The male siblings of women who have high blood pressure during pregnancy are at an increased risk of developing cardiovascular disease in later life, a new study finds.

Common 'heart attack' blood test may predict future hypertension
Source: Hypertension News From Medical News Today [2015.08.27]
Small rises in troponin levels may have value as markers for subclinical heart damage and high blood pressureAnalysis of blood samples from more than 5,000 people suggests that a more sensitive...

ICD-10: Coding for Hypertension and Heart Disease
Source: Medscape Business of Medicine Headlines [2015.08.25]
There are some important elements to be aware of when coding for hypertension, heart disease, and kidney disease in ICD-10.
Medscape Business of Medicine

more news >>

Published Studies Related to Lotrel (Amlodipine / Benazepril)

Comparative efficacy and safety of amlodipine/benazepril combination therapy and amlodipine monotherapy in severe hypertension. [2010.06]
This multicentre, double-blind, trial in subjects with severe hypertension compared the efficacy and tolerability of two parallel drug regimens: A/B (amlodipine/benazepril: 5/20 or 10/40 mg daily, if necessary) with A (amlodipine: 5 or 10 mg daily, if necessary)... We conclude that titration of amlodipine and benazepril in single-pill combinations is more effective than titration of amlodipine alone for rapid BP control in patients with severe hypertension.

An eight-week, multicenter, randomized, double-blind study to evaluate the efficacy and tolerability of fixed-dose amlodipine/benazepril combination in comparison with amlodipine as first-line therapy in chinese patients with mild to moderate hypertension. [2008.06]
CONCLUSIONS: In this group of patients, comparable antihypertensive effects were seen with the fixed-dose combination therapy, compared with amlodipine monotherapy. Both treatments appeared well tolerated in the studied population, but cough was more common in the fixed-dose combination group.

The effects of high-dose amlodipine/benazepril combination therapies on blood pressure reduction in patients not adequately controlled with amlodipine monotherapy. [2007.03]
BACKGROUND: This study compared the efficacy and safety of amlodipine/benazepril (10/40 mg/day and 10/20 mg/day) with amlodipine 10 mg/day in patients whose blood pressure (BP) was not adequately controlled with amlodipine monotherapy... CONCLUSION: Amlodipine/benazepril combinations were well tolerated and resulted in significant BP reductions and better BP responder rates than amlodipine monotherapy.

Efficacy of combination therapy with amlodipine besylate/benazepril hydrochloride for lowering systolic blood pressure in stage 2 hypertension. [2006.05]
The Systolic Evaluation of Lotrel Efficacy and Comparative Therapies (SELECT) study compared daily treatment with combination amlodipine besylate/benazepril hydrochloride 5/20 mg, amlodipine besylate 5 mg, and benazepril hydrochloride 20 mg in 505 patients aged 55 years of age or older with stage 2 hypertension (systolic blood pressure [BP] > or =160 and < or =200 mm Hg and diastolic BP > or =60 and < or =100 mm Hg)...

Efficacy of combination therapy for systolic blood pressure in patients with severe systolic hypertension: the Systolic Evaluation of Lotrel Efficacy and Comparative Therapies (SELECT) study. [2005.11]
Systolic hypertension is predominant among patients over 50 years of age, is a more important cardiovascular risk factor than diastolic blood pressure, and is more difficult to control than diastolic blood pressure. Consequently, the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) recommends combination therapy as first-line treatment for patients with stage 2 hypertension...

more studies >>

Clinical Trials Related to Lotrel (Amlodipine / Benazepril)

Amlodipine-Benazepril 10mg-20mg Capsules in Healthy Subjects Under Fed Conditions [Completed]

Amlodipine-Benazepril 10mg-20mg Capsules in Healthy Subjects Under Fasting Conditions [Completed]

Bioequivalence Study of 10 mg Amlodipine Besylate/ 20 mg Benazepril Hydrochloride Capsules of Dr.Reddys Laboratories Limited Under Fasting Conditions [Completed]
The objective of this study was to compare the single-dose relative bioavailability of Dr. Reddy's Laboratories, Ltd. and Lotrel®) 10 mg amlodipine besylate/20 mg benazepril hydrochloride capsules, under fasting conditions.

Bioequivalence Study of 10 mg Amlodipine Besylate/ 20 mg Benazepril Hydrochloride Capsules of Dr.Reddys Laboratories Limited Under Non-fasting (Fed) Conditions [Completed]
The objective of this study was to compare the single-dose relative bioavailability of Dr. Reddy's Laboratories, Ltd. and Lotrel®) 10 mg amlodipine besylate/20 mg benazepril hydrochloride capsules, under non-fasting (fed) conditions.

Bioequivalence Study of Amlodipine Besylate/Benazepril HCl 10 mg/40 mg Capsules of Dr. Reddy's Under Fed Conditions [Completed]
The purpose of this study single dose bioequivalence of Amlodipine Besylate/Benazepril HCl 10 mg/40 mg capsules with Lotrel® capsules in healthy human subjects and monitor clinical status, adverse events and laboratory investigations and assess relative safety and tolerance under fed conditions.

more trials >>

Reports of Suspected Lotrel (Amlodipine / Benazepril) Side Effects

Drug Ineffective (5)Blood Pressure Increased (5)Headache (4)Dizziness (4)Cough (4)Rash (4)LIP Swelling (3)Urticaria (3)Drug Hypersensitivity (3)Cerebrovascular Accident (3)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Lotrel has an overall score of 7.67. The effectiveness score is 9.33 and the side effect score is 6.67. The scores are on ten point scale: 10 - best, 1 - worst.
 

Lotrel review by 57 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   blood pressure
Dosage & duration:   10/20 (dosage frequency: every nite) for the period of 2 years
Other conditions:   hepatitis c
Other drugs taken:   none
  
Reported Results
Benefits:   blodd pressure remained in the low area
Side effects:   drowsiness, loss of libido
Comments:   once a day

 

Lotrel review by 45 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   High Blood Pressure
Dosage & duration:   5mg./10mg taken 1 x daily for the period of 30 days
Other conditions:   Celiac Disease
Other drugs taken:   Trazadone
  
Reported Results
Benefits:   I have slightly high blood pressure on the diastolic side. Lotrel did a good job at maintaining good levels without increasing my pulse which I experienced with other BP meds.
Side effects:   After introducing Lotrel within two weeks I notices small red dots appear on my ankles which I thought was just a heat rash. I developed Petechiae which is the bleeding of small capillaries in the skin or mucous membrane. It appears as round pinpoint sized dots that vary in colour from red to blue or purple. These dots most commonly appear on the legs but can appear all over the body. Also an onset on Acne developed on my back at about the same time which was quite severe, and I have never had Acne related problems, even in my youth.
Comments:   Currently my physician has taken me off of my BP meds to allow the Petechiae to fade, and to ensure that the reaction was indeed related to the Lotrel. It has been 4 days and slowly the rash and redness is mellowing.

 

Lotrel review by 45 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   High Blood Pressure
Dosage & duration:   5mg./10mg taken 1 x daily for the period of 30 days
Other conditions:   Celiac Disease
Other drugs taken:   Trazadone
  
Reported Results
Benefits:   I have slightly high blood pressure on the diastolic side. Lotrel did a good job at maintaining good levels without increasing my pulse which I experienced with other BP meds.
Side effects:   After introducing Lotrel within two weeks I notices small red dots appear on my ankles which I thought was just a heat rash. I developed Petechiae which is the bleeding of small capillaries in the skin or mucous membrane. It appears as round pinpoint sized dots that vary in colour from red to blue or purple. These dots most commonly appear on the legs but can appear all over the body. Also an onset on Acne developed on my back at about the same time which was quite severe, and I have never had Acne related problems, even in my youth.
Comments:   Currently my physician has taken me off of my BP meds to allow the Petechiae to fade, and to ensure that the reaction was indeed related to the Lotrel. It has been 4 days and slowly the rash and redness is mellowing.

See all Lotrel reviews / ratings >>

Page last updated: 2015-08-29

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