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Lotrel (Amlodipine Besylate / Benazepril Hydrochloride) - Summary

 

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USE IN PREGNANCY

When used in pregnancy, ACE inhibitors can cause injury and even death to the developing fetus.  When pregnancy is detected, Lotrel should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.

 

LOTREL SUMMARY

Lotrel®

Benazepril hydrochloride is a white to off-white crystalline powder, soluble (>100 mg/mL) in water, in ethanol, and in methanol.

Lotrel is indicated for the treatment of hypertension.

This fixed combination drug is not indicated for the ini-tial therapy of hypertension (see DOSAGE AND ADMINISTRATION).

In using Lotrel, consideration should be given to the fact that an ACE inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen-vascular disease. Available data are insufficient to show that benazepril does not have a similar risk (see WARNINGS, Neutropenia/Agranulocytosis).

Black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to nonblacks.

LOTREL NEWS HIGHLIGHTS

Media Articles Related to Lotrel (Amlodipine / Benazepril)

Pseudotumor Cerebri (Idiopathic Intracranial Hypertension)
Source: MedicineNet Brain Tumor Specialty [2008.09.30]

Study Finds Antioxidant Deficiency Linked To Pulmonary Hypertension
Source: Hypertension News From Medical News Today [2008.09.24]

Vitamin C Might Help Lower Hypertension
Source: MedicineNet High Blood Pressure Specialty [2008.09.22]

Using Honeybee Venom Toxin To Develop A New Tool For Studying Hypertension
Source: Hypertension News From Medical News Today [2008.09.19]

Prehypertension by Age 35 Clogs Arteries
Source: MedicineNet CAT Scan Specialty [2008.07.15]

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Published Studies Related to Lotrel (Amlodipine / Benazepril)

The effects of high-dose amlodipine/benazepril combination therapies on blood pressure reduction in patients not adequately controlled with amlodipine monotherapy. [2007.03]

Efficacy of combination therapy with amlodipine besylate/benazepril hydrochloride for lowering systolic blood pressure in stage 2 hypertension. [2006.05]

Efficacy of combination therapy for systolic blood pressure in patients with severe systolic hypertension: the Systolic Evaluation of Lotrel Efficacy and Comparative Therapies (SELECT) study. [2005.11]

Amlodipine/benazepril combination therapy for hypertensive patients nonresponsive to benazepril monotherapy. [2004.07]

Effect of benazepril amlodipine combination on fibrinolysis in hypertensive diabetic patients. [2003.08]

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Clinical Trials Related to Lotrel (Amlodipine / Benazepril)

Fed Study of Amlodipine and Benazepril HCl Capsules 10 mg/20 mg to Lotrel® Capsules 10 mg/20 mg [Completed]

Fasting Study of Amlodipine and Benazepril HCl Capsules 10 mg/20 mg to Lotrel® Capsules 10 mg/20 mg [Completed]

Tarka® vs. Lotrel® in Hypertensive, Diabetic Subjects With Renal Disease (TANDEM) [Active, not recruiting]

Fed Study of Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Lotensin HCT® Tablets 20 mg/25 mg [Completed]

Fasting Study of Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Lotensin HCT® Tablets 20 mg/25 mg [Completed]

more>>

Page last updated: 2008-09-30

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