LOTENSIN HCT SUMMARY
Benazepril inhibit angiotensin-converting enzyme (ACE). Hydrochlorothiazide is a diuretiuc.
Lotensin HCT is indicated for the treatment of hypertension.
This fixed combination drug is not indicated for the ini-tial therapy of hypertension (DOSAGE AND ADMINISTRATION).
In using Lotensin HCT, consideration should be given to the fact that another angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen-vascular disease. Available data are insufficient to show that benazepril does not have a similar risk (see WARNINGS, Neutropenia/ Agranulocytosis).
Black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to nonblacks.
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NEWS HIGHLIGHTSMedia Articles Related to Lotensin HCT (Benazepril / Hydrochlorothiazide)
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Published Studies Related to Lotensin HCT (Benazepril / Hydrochlorothiazide)
Comparison of benazepril-amlodipine and captopril-thiazide combinations in the management of mild-to-moderate hypertension. [2002.06] CONCLUSIONS: These data suggest a higher antihypertensive efficacy of the fixed combination BZ 10 mg+AM 5 mg as compared with CP 50 mg+HT 25 mg.
Combination of hydrochlorothiazide or benazepril with valsartan in hypertensive patients unresponsive to valsartan alone. [2001.11] OBJECTIVE : The aim of this open multicentric study was to investigate the efficacy and safety of the addition of an angiotensin converting enzyme (ACE) inhibitor (benazepril, 10 mg/day) or a diuretic (hydrochlorothiazide, 12.5 mg/day) for 4 weeks in patients with mild to moderate essential hypertension having been treated for 4 weeks by an angiotensin II antagonist (valsartan, 80 mg/day) but still having a diastolic blood pressure (BP) > 90 mmHg on this medication given alone...
[Antihypertensive action and predictive factors of efficacy of benazepril in mild-to-moderate hypertension: clinical trial in general medical practice on 16,987 patients] [1998.01] CONCLUSION: This large-scale study confirms, the antihypertensive efficacy and good tolerability of benazepril alone or associated with hydrochlorothiazide in general practice.
Effects of benazepril and hydrochlorothiazide, given alone and in low- and high-dose combinations, on blood pressure in patients with hypertension. [1996.01] OBJECTIVE: To assess the efficacy and safety of several combinations of benazepril, an angiotensin-converting enzyme inhibitor, and hydrochlorothiazide, as compared with placebo, in the treatment of patients with essential hypertension... CONCLUSION: Benazepril in combination with hydrochlorothiazide, including a low-dose combination of 5/6.25 mg, is effective in reducing sitting diastolic and systolic blood pressure in patients with hypertension.
[Comparison of blood pressure profile during exercise with benazepril 10 mg and benazepril 5 mg/hydrochlorothiazide 6.25 mg fixed combination] [1995.07] This double-blind placebo-controlled study was designed to compare the efficacy of benazepril 10 mg (BZ 10) and the low-dose combination benazepril 5 mg/hydrochlorothiazide 6.25 mg (BZ + HCTZ) on exercise blood pressure in 71 patients with mild to moderate hypertension (diastolic blood pressure 95 to 114 mmHg at the end of a 2 week placebo run-in)...
Clinical Trials Related to Lotensin HCT (Benazepril / Hydrochlorothiazide)
Bioequivalence Study of 10 mg Amlodipine Besylate/ 20 mg Benazepril Hydrochloride Capsules of Dr.Reddys Laboratories Limited Under Fasting Conditions [Completed]
The objective of this study was to compare the single-dose relative bioavailability of Dr.
Reddy's Laboratories, Ltd. and Lotrel®) 10 mg amlodipine besylate/20 mg benazepril
hydrochloride capsules, under fasting conditions.
Bioequivalence Study of 10 mg Amlodipine Besylate/ 20 mg Benazepril Hydrochloride Capsules of Dr.Reddys Laboratories Limited Under Non-fasting (Fed) Conditions [Completed]
The objective of this study was to compare the single-dose relative bioavailability of Dr.
Reddy's Laboratories, Ltd. and Lotrel®) 10 mg amlodipine besylate/20 mg benazepril
hydrochloride capsules, under non-fasting (fed) conditions.
Amlodipine-Benazepril 10mg-20mg Capsules in Healthy Subjects Under Fed Conditions [Completed]
Amlodipine-Benazepril 10mg-20mg Capsules in Healthy Subjects Under Fasting Conditions [Completed]
Bioequivalence Study of Amlodipine Besylate/Benazepril HCl 10 mg/40 mg Capsules of Dr. Reddy's Under Fed Conditions [Completed]
The purpose of this study single dose bioequivalence of Amlodipine Besylate/Benazepril HCl
10 mg/40 mg capsules with Lotrel® capsules in healthy human subjects and monitor clinical
status, adverse events and laboratory investigations and assess relative safety and
tolerance under fed conditions.
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