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Lotensin HCT (Benazepril Hydrochloride / Hydrochlorothiazide) - Summary

 
 



USE IN PREGNANCY

When used in pregnancy, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, Lotensin HCT should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.

 

LOTENSIN HCT SUMMARY

Lotensin HCT

Benazepril inhibit angiotensin-converting enzyme (ACE). Hydrochlorothiazide is a diuretiuc.

Lotensin HCT is indicated for the treatment of hypertension.

This fixed combination drug is not indicated for the ini-tial therapy of hypertension (DOSAGE AND ADMINISTRATION).

In using Lotensin HCT, consideration should be given to the fact that another angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen-vascular disease. Available data are insufficient to show that benazepril does not have a similar risk (see WARNINGS, Neutropenia/ Agranulocytosis).

Black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to nonblacks.
See all Lotensin HCT indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Lotensin HCT (Benazepril / Hydrochlorothiazide)

Diet Effects Debated in Intracranial Hypertension
Source: Medscape Ophthalmology Headlines [2015.02.27]
Does acetazolamide improve symptoms of intracranial hypertension by lowering cerebrospinal fluid pressure, or does it work by increasing weight loss?
Medscape Medical News

Pulmonary Hypertension
Source: MedicineNet Fainting Specialty [2015.02.19]
Title: Pulmonary Hypertension
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 2/19/2015 12:00:00 AM

"Danger" molecule may be new therapeutic target for male hypertension
Source: Hypertension News From Medical News Today [2015.02.17]
Higher levels of a "danger" molecule may be one reason males tend to become hypertensive earlier and more severely than females, scientists say.

Pregnancy associated hypertension linked to an increased frequency of subsequent hypertension and metabolic syndrome
Source: Hypertension News From Medical News Today [2015.02.04]
In a study to be presented on Feb. 5 in an oral concurrent session at 2:45 p.m.

New hypertension guidelines could save lives and money
Source: Hypertension News From Medical News Today [2015.01.30]
Increased treatment of severe hypertension particularly cost-effectiveFull implementation of new hypertension guidelines could prevent 56,000 cardiovascular disease events (mostly heart attacks...

more news >>

Published Studies Related to Lotensin HCT (Benazepril / Hydrochlorothiazide)

Comparison of benazepril-amlodipine and captopril-thiazide combinations in the management of mild-to-moderate hypertension. [2002.06]
CONCLUSIONS: These data suggest a higher antihypertensive efficacy of the fixed combination BZ 10 mg+AM 5 mg as compared with CP 50 mg+HT 25 mg.

Combination of hydrochlorothiazide or benazepril with valsartan in hypertensive patients unresponsive to valsartan alone. [2001.11]
OBJECTIVE : The aim of this open multicentric study was to investigate the efficacy and safety of the addition of an angiotensin converting enzyme (ACE) inhibitor (benazepril, 10 mg/day) or a diuretic (hydrochlorothiazide, 12.5 mg/day) for 4 weeks in patients with mild to moderate essential hypertension having been treated for 4 weeks by an angiotensin II antagonist (valsartan, 80 mg/day) but still having a diastolic blood pressure (BP) > 90 mmHg on this medication given alone...

[Antihypertensive action and predictive factors of efficacy of benazepril in mild-to-moderate hypertension: clinical trial in general medical practice on 16,987 patients] [1998.01]
CONCLUSION: This large-scale study confirms, the antihypertensive efficacy and good tolerability of benazepril alone or associated with hydrochlorothiazide in general practice.

Effects of benazepril and hydrochlorothiazide, given alone and in low- and high-dose combinations, on blood pressure in patients with hypertension. [1996.01]
OBJECTIVE: To assess the efficacy and safety of several combinations of benazepril, an angiotensin-converting enzyme inhibitor, and hydrochlorothiazide, as compared with placebo, in the treatment of patients with essential hypertension... CONCLUSION: Benazepril in combination with hydrochlorothiazide, including a low-dose combination of 5/6.25 mg, is effective in reducing sitting diastolic and systolic blood pressure in patients with hypertension.

[Comparison of blood pressure profile during exercise with benazepril 10 mg and benazepril 5 mg/hydrochlorothiazide 6.25 mg fixed combination] [1995.07]
This double-blind placebo-controlled study was designed to compare the efficacy of benazepril 10 mg (BZ 10) and the low-dose combination benazepril 5 mg/hydrochlorothiazide 6.25 mg (BZ + HCTZ) on exercise blood pressure in 71 patients with mild to moderate hypertension (diastolic blood pressure 95 to 114 mmHg at the end of a 2 week placebo run-in)...

more studies >>

Clinical Trials Related to Lotensin HCT (Benazepril / Hydrochlorothiazide)

Fed Study of Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Lotensin HCT® Tablets 20 mg/25 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan benazepril HCl and hydrochlorothiazide 20 mg/25 mg to Novartis Lotensin HCT® 20 mg/25 mg combination tablets following a single, oral 40 mg/50 mg (2 x 20 mg/25 mg) dose administration under fed conditions.

Fasting Study of Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Lotensin HCT® Tablets 20 mg/25 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan benazepril HCl and hydrochlorothiazide 20 mg/25 mg to Novartis Lotensin HCT® 20 mg/25 mg combination tablets following a single, oral 40 mg/50 mg (2 x 20 mg/25 mg) dose administration under fasting conditions.

Fed Study of Amlodipine and Benazepril HCl Capsules 10 mg/20 mg to Lotrel® Capsules 10 mg/20 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan amlodipine and benazepril HCl 10 mg/20 mg to Novartis Lotrel® 10 mg/20 mg combination capsules following a single, oral 10 mg/20 mg (1 x 10 mg/20 mg) dose administered under fed conditions.

Fasting Study of Amlodipine and Benazepril HCl Capsules 10 mg/20 mg to Lotrel® Capsules 10 mg/20 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's amlodipine and benazepril HCl 10 mg/20 mg to Novartis' Lotrel® 10 mg/20 mg combination capsules following a single, oral 10 mg/20 mg (1 x 10mg/20mg) dose administered under fasting conditions.

Combination of Benazepril Plus Hydrochlorothiazide in Chinese Patients With Mild to Moderate Essential Hypertension [Completed]
This study will evaluate efficacy and safety data for benazepril/hydrochlorothiazide in adult Chinese patients with mild to moderate essential hypertension. Patients whose blood pressure is not adequately controlled with benazepril monotherapy during a 4 week run-in period will be randomly allocated to double blind treatment over 8 weeks with either a combination of benazepril/hydrochlorothiazide per day or continuation of benazepril per day.

more trials >>


Page last updated: 2015-02-27

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