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Lortab (Hydrocodone Bitartrate / Acetaminophen) - Summary

 
 



LORTAB SUMMARY

Hydrocodone bitartrate and acetaminophen is supplied in tablet form for oral administration.

Lortab Tablets are indicated for the relief of moderate to moderately severe pain.


See all Lortab indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Lortab (Hydrocodone / Acetaminophen)

Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge. [2014]
(DEA) Schedule III narcotics... CONCLUSIONS: Both medications decreased NRS pain scores by approximately 50%.

Hydrocodone/acetaminophen and tramadol chlorhydrate combination tablets for the management of chronic cancer pain: a double-blind comparative trial. [2008.01]
OBJETIVES: The purpose of this study was to compare the analgesic efficacy and tolerability of opioids hydrocodone and tramadol in the relief of cancer pain... CONCLUSIONS: There was no superior analgesic efficacy with the administration of hydrocodone/acetaminophen when compared to patients receiving tramadol in the relief of cancer pain. Tramadol produced more mild side effects than hydrocodone.

Tramadol/acetaminophen or hydrocodone/acetaminophen for the treatment of ankle sprain: a randomized, placebo-controlled trial. [2007.04]
STUDY OBJECTIVE: This randomized, multicenter study compares the analgesic efficacy and safety of tramadol/acetaminophen versus hydrocodone/acetaminophen versus placebo for the treatment of acute musculoskeletal pain caused by ankle sprain... CONCLUSION: One or 2 capsules of 37.5 mg tramadol/325 mg acetaminophen and 1 capsule of 7.5 mg hydrocodone/650 mg acetaminophen were well tolerated, had comparable clinical utility, and were more effective than placebo in the management of acute musculoskeletal pain caused by ankle sprain.

Tramadol/Acetaminophen or Hydrocodone/Acetaminophen for the Treatment of Ankle Sprain: A Randomized, Placebo-Controlled Trial. [2006.11.17]
STUDY OBJECTIVE: This randomized, multicenter study compares the analgesic efficacy and safety of tramadol/acetaminophen versus hydrocodone/acetaminophen versus placebo for the treatment of acute musculoskeletal pain caused by ankle sprain... CONCLUSION: One or 2 capsules of 37.5 mg tramadol/325 mg acetaminophen and 1 capsule of 7.5 mg hydrocodone/650 mg acetaminophen were well tolerated, had comparable clinical utility, and were more effective than placebo in the management of acute musculoskeletal pain caused by ankle sprain.

Rofecoxib versus hydrocodone/acetaminophen for postoperative analgesia in functional endoscopic sinus surgery. [2006.04]
OBJECTIVES/HYPOTHESIS: Functional endoscopic sinus surgery (FESS) is less invasive and more tissue sparing than extirpative techniques, with an assumed benefit of diminished postoperative pain. Oral opioids are commonly prescribed after sinus surgery but are associated with adverse effects, including gastrointestinal and neurologic symptoms. Nonopioid analgesics have been suggested to offer similar pain control efficacy with fewer adverse effects. STUDY DESIGN: To investigate postoperative analgesia in FESS, a prospective randomized, double-blinded comparison of hydrocodone/acetaminophen 7.5/750 mg (an opioidderivative) with rofecoxib 50 mg (a cyclooxygenase-2 inhibitor) was performed... CONCLUSIONS: The use of nonopioid analgesics after FESS may provide similar pain control to oral opioids.

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Clinical Trials Related to Lortab (Hydrocodone / Acetaminophen)

A Study Comparing VicodinŽ CR and NORCOŽ to Placebo in Subjects With Acute Pain Following Bunionectomy [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of the administration of Extended Release Hydrocodone/Acetaminophen and Immediate Release Hydrocodone/Acetaminophen with placebo over a 12 hour dosing period in patients who have had a bunionectomy, and to assess the safety of the drug for 7 days after patients are discharged from the hospital.

Pharmacokinetics and Bioequivalence of Vycavert (10 mg Hydrocodone Bitartrate/325 mg Acetaminophen) Compared to the Reference Drug Norco [Recruiting]
This study aims to determine whether the hydrocodone and acetaminophen exposures following oral dosing of Vycavert are comparable to those following oral dosing of Norco.

A Study to Evaluate the Interaction Between VicodinŽ CR and Ethanol in Healthy Male and Female Moderate Alcohol Drinkers [Completed]

Post-operative Pain Control After Pediatric Adenotonsillectomy [Recruiting]
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in children. Post-operative pain following adenotonsillectomy has significant morbidity and may result in prolonged hospital stay or re-admission to the hospital. Post-operative analgesia is most commonly managed with narcotic-containing pain medication. In recent years however, there is evidence that some patients may manifest increased sensitivity to narcotics, resulting in life-threatening respiratory compromise. Though there is a theoretical risk that nonsteroidal anti-inflammatory drugs (NSAIDs) increase bleeding time by disrupting platelet aggregation, evidence of detrimental effects (i. e. increased risk of postoperative bleeding) remains inconclusive for these generally well-tolerated medications. The goal of this study is to determine the incidence of post-operative bleeding and to determine the efficacy of NSAIDs in the management of post-operative pain following pediatric adenotonsillectomy, versus more commonly used narcotic pain medication. The study design will be an initial retrospective study to collect pilot data on the incidence of postoperative hemorrhage and indicators of adequate/inadequate pain control in children age 4 to 17 undergoing adenotonsillectomy. This will be followed by a prospective, randomized, single-blind controlled study in which orally-administered ibuprofen (test intervention) is compared to acetaminophen-hydrocodone (control intervention) in the postoperative period following adenotonsillectomy.

A Study Comparing the Analgesic Activity of Extended Release Hydrocodone/Acetaminophen (VicodinŽ CR) and Placebo in Subjects With Pain Following Bunionectomy Surgery [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of the administration of 2 different dose levels of Extended Release Hydrocodone/Acetaminophen with placebo over a 48 hour dosing period in patients who have had bunionectomy surgery, and to assess the safety of the drug for 7 days after patients are discharged from the hospital.

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Reports of Suspected Lortab (Hydrocodone / Acetaminophen) Side Effects

Headache (27)Vomiting (27)Fatigue (21)Abdominal Pain (19)Nausea (19)Malaise (18)Cognitive Disorder (18)Drug Ineffective (17)Anxiety (17)Pain (15)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 6 ratings/reviews, Lortab has an overall score of 7. The effectiveness score is 9 and the side effect score is 6.33. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Lortab review by 37 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   pain
Dosage & duration:   10 mg taken one to two tablets every eight hours for the period of still taking it
Other conditions:   neck pain, arm pain, hands numbness
Other drugs taken:   Diazapam
  
Reported Results
Benefits:   Had surgery on my neck, the lortab reduce the pain.The lortab help relieve th pain upto eight hours so I did not need to take as many pills to find release. This is a good thing because I do not like pills. This medication helped tremedously.
Side effects:   a little nausea. This medication has a high risk of addiction. When you take it be very careful that you do not misuse. The lortab reduces the pain on the first pill however as you take the medication it seems to take more pills as you go along to recieve the same releif as first.
Comments:   take one to two tablets by mouth every 8 hours as needed for pain.

 

Lortab review by 23 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   oral surgery
Dosage & duration:   1-2 tablets taken every 6 hours for the period of 1 week
Other conditions:   none
Other drugs taken:   amoxicillin, ibuprofen
  
Reported Results
Benefits:   considerably reduced pain, if i experienced any at all.
Side effects:   With two tablets, the main difference was moderate to severe drowsiness. With either dosage, I experienced vibrant dreams/nightmares and/or an elated/lightheaded feeling while awake. Constipation relieved with extra fiber.
Comments:   In my experience with this medication, I've found it moderately addicting and should be taken with caution. I advise to take when in mild-moderate pain because that's what it's for, but hold off taking it every six hours (or as prescribed) if pain is not an issue.

 

Lortab review by 37 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   pain from recovering from abdominal surgery
Dosage & duration:   10 (dosage frequency: every 6 hours) for the period of few weeks
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   treated pain due to an open wound from abdominal surgery
Side effects:   severe nausea, dizziness, lightheaded...I couldn't eat or drink many foods
Comments:   taking pain medication while recovering from surgery...had an open wound with wound vac. The pain was so severe, especially when it came time to change the dressings and clean out the wound in which case I would double up on the medication. It helped with the pain, but also doubled the side effects I was feeling.

See all Lortab reviews / ratings >>

Page last updated: 2014-11-30

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