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Lorazepam (Lorazepam) - Summary

 
 



LORAZEPAM SUMMARY

LORAZEPAM INJECTION USP

Lorazepam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration. It has the chemical formula: 7-chloro-5(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2 H -1, 4-benzodiazepin-2-one.

Status Epilepticus

Lorazepam Injection is indicated for the treatment of status epilepticus.

Preanesthetic

Lorazepam Injection is indicated in adult patients for preanesthetic medication, producing sedation (sleepiness or drowsiness), relief of anxiety, and a decreased ability to recall events related to the day of surgery. It is most useful in those patients who are anxious about their surgical procedure and who would prefer to have diminished recall of the events of the day of surgery (see PRECAUTIONS, Information for Patients).


See all Lorazepam indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Lorazepam

RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics. [2011.10]
Early treatment of prolonged seizures with benzodiazepines given intravenously by paramedics in the prehospital setting has been shown to be associated with improved outcomes. However, an increasing number of Emergency Medical System (EMS) protocols use an intramuscular (IM) route because it is faster and consistently achievable...

Lorazepam effects on Word Memory Test performance: a randomized, double-blind, placebo-controlled, crossover trial. [2011.07]
The Word Memory Test (WMT) is a common measure of symptom validity. To investigate the effects of acute benzodiazepines on WMT scores, oral lorazepam 2 mg (LOR) and placebo were administered 1 week apart in a randomized, double-blind, placebo-controlled, crossover study.

Intranasal versus intravenous lorazepam for control of acute seizures in children: a randomized open-label study. [2011.04]
PURPOSE: Intravenous lorazepam is considered the drug of first choice for control of acute convulsive seizures. However, resource or personnel constraints necessitate the study of alternative routes and medications...

Neurocognitive effects of brivaracetam, levetiracetam, and lorazepam. [2011.02]
PURPOSE: Brivaracetam (BRV) is a new anticonvulsant under development...

One milligram of lorazepam does not decrease anxiety induced by CCK-4 in healthy volunteers: investigation of neural correlates with BOLD MRI. [2011.01]
Benzodiazepine effects on cholecystokinin tetrapeptide (CCK-4)-induced panic attack (PA) in humans are incompletely characterized, in particular on the neurofunctional level. This work explores the effects of lorazepam on brain activity and behavioral and physiological symptoms related to CCK-4-induced PA in healthy volunteers...

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Clinical Trials Related to Lorazepam

Lorazepam Sedation for Critically Ill Children [Suspended]
This clinical trial is being performed under the Best Pharmaceuticals for Children Act, signed into law in 2002 in order to improve pediatric labeling for off-patent drugs. The purpose of this study is to make sure that lorazepam, when given to children who are very sick in the Intensive Care Unit and who are on a breathing machine, is safe and works as well as a drug called midazolam. Midazolam is already approved by the FDA for this use, but lorazepam is not, even though both drugs are commonly used for sedation.

A Comparison of Lorazepam and Diazepam in the Treatment of Alcohol Withdrawal [Completed]
The purpose of this study is to compare the efficacy of two commonly used medications in the treatment of alcohol withdrawal, diazepam and lorazepam.

Fasting Study of Lorazepam Tablets 2 mg and Ativan Tablets 2 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's lorazepam 2 mg tablets to Wyeth's Ativan 2 mg tablets following a single, oral 2 mg (1 x 2 mg) dose administered under fasting conditions.

Efficacy and Safety Study Comparing Lorazepam and Diazepam for Children in the Emergency Department With Seizures (Status 2) [Recruiting]
Children with seizures are frequently seen in the emergency department. The drug lorazepam, which is commonly used, is not labeled by the US Food and Drug Administration for children for this use. The FDA, under the Best Pharmaceuticals for Children Act, has requested that a study comparing diazepam, a drug that is labeled by the FDA for this indication, with lorazepam be performed. The study will show whether one drug is more effective and safe than the other.

The Impact of Lorazepam on Cognition in APOE e4 Carriers [Completed]
We expect the results of this pilot study to justify a larger study that follows people to determine if certain tests of memory and attention, performed while sleepiness is induced by a single dose of lorazepam (a widely used anti-anxiety medication) could predict an individual's risk of developing AD. We plan to compare cognitively normal people who possess a common gene that increases risk for AD— the apolipoprotein E (APOE) e4 allele—to individuals without this gene. We hypothesize that a single 2 mg dose of lorazepam will cause more cognitive impairment in carriers of the APOE e4 allele than in noncarriers, and that the carriers will recover more slowly from these impairments than noncarriers.

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Reports of Suspected Lorazepam Side Effects

Completed Suicide (230)Respiratory Arrest (136)Cardiac Arrest (116)Toxicity TO Various Agents (103)Suicide Attempt (78)Agitation (75)Somnolence (72)Delirium (70)Fall (68)Poisoning (62)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 11 ratings/reviews, Lorazepam has an overall score of 7.55. The effectiveness score is 7.82 and the side effect score is 7.64. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Lorazepam review by 51 year old male patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   ANXIETY
Dosage & duration:   0.5 MG taken once a day for the period of 1 WEEK
Other conditions:   HIGH BLOOD PRESSURE
Other drugs taken:   HYZARR AND LIPIDOR
  
Reported Results
Benefits:   THE BENEFITS WERE NONE. HOWEVER, IT DID NOT CAUSE ME ANY DIFFICULTIES OR SIDE EFFECTS. I APPROVED OF THE IDEA OF TAKING THE MEDICATION TO REDUCE MY GENERAL LOW LEVEL ANXIETY AS AN ADDITIONAL TREATMENT TO LOWERING MY HIGH BLOOD PRESSURE. BUT I EXPERIENCED NO IMPROVEMENTS AT THIS DOSE.
Side effects:   THE IDEA WAS TO HELP WITH ANXIETY AS AN AID TO LOWER MY BLOOD PRESSURE. HOWEVER, NEITHER MY BLOOD PRESSURE, WITH ANOTHER MEDICATION, OR THE LEVEL OF ANXIETY WAS REDUCED. THE LORAZEPAM WAS STOPPED AFTER A WEEK WHEN I COMPLAINED OF INEFFECTIVENESS. I DID NOT EXPERIENCE ANY SIDE EFFECTS WITH THIS MEDICATION.
Comments:   I WAS TO TAKE THIS MEDICATION ONCE A DAY IN THE MORNING. WHEN I FELT NO BENEFIT I DISCUSSED IT WITH THE DOCTOR WHO SUGGESTED AN INCREASE OF THE DOSAGE. I DECLINED. THE TREATMENT THEORY WAS THAT THE LORAZEPAM WOULD HELP ME WITH ANXIETY AND STRESS WHICH IN TURN WOULD BE AN AID IN ADDITION WITH THE BLOOD PRESSURE MEDICATION TO LOWER MY BLOOD PRESSURE.

 

Lorazepam review by 45 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Mild sedative
Dosage & duration:   1 mg taken 2 perscriptions for the period of taken when needed
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   The prescription was given for anxiety and to help with sleep during long flights and when under high anxiety situations. Lorazepam helped to calm and induced drowziness. I would not recomend this if you have to stay alert as it can make functioning dificult.
Side effects:   none
Comments:   To be taken when needed to relieve stress and assist in sleeping.

 

Lorazepam review by 52 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   anxiety
Dosage & duration:   2 mg taken 4 times for the period of about 2 months
Other conditions:   headaches
Other drugs taken:   ibuprophen
  
Reported Results
Benefits:   The ativan decreased my anxiety so that I was able to sleep through the night.
Side effects:   2 mg was way too much. After 7 hours of sleep, I continued to be spaced out and clumsy, bumping into walls and dropping things for another 7 hours. My mind also felt really slow, stunned and stupid. These side effects were so strong, my co-workers noticed and were concerned for me. A week later, I took half a pill to ease my anxiety and help me sleep. The side effects were less, but still noticeable by others the next day at work. The last two times I tried ativan, I only took 1/4 of a pill. It did still ease my anxiety and the side effects were mild, but I decided I'd rather live with the anxiety than live with a mind that felt slow and stupid.
Comments:   Dissolve one tablet under the tongue at bedtime as needed to a maximum of 3 tablets per week.

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Page last updated: 2011-12-09

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