LORAZEPAM SUMMARY
Lorazepam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration. It has the chemical formula 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2
H
-1,4-benzodiazepin-2-one.
Status Epilepticus
Lorazepam Injection is indicated for the treatment
of status epilepticus.
Preanesthetic
Lorazepam injection
is indicated in adult patients for preanesthetic medication, producing
sedation (sleepiness or drowsiness), relief of anxiety, and a decreased
ability to recall events related to the day of surgery. It is most
useful in those patients who are anxious about their surgical procedure
and who would prefer to have diminished recall of the events of the
day of surgery (see
PRECAUTIONS:
Information for Patients
).
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NEWS HIGHLIGHTSMedia Articles Related to Lorazepam
Final Frontier: Managing Acute Delirium in Last Days of Life Source: Medscape Hematology-Oncology Headlines [2017.09.28] Lorazepam plus haloperidol were more effective than haloperidol alone in controlling agitated delirium in patients with advanced cancer. Medscape Medical News
Published Studies Related to Lorazepam
Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical
trial. [2014] IMPORTANCE: Benzodiazepines are considered first-line therapy for pediatric
status epilepticus...
Intravenous promethazine versus lorazepam for the treatment of peripheral vertigo
in the emergency department: A double blind, randomized clinical trial of
efficacy and safety. [2014] vertigo reduction compared with lorazepam in ED patients... CONCLUSION: Our study demonstrated the evidence that promethazine is superior to
A comparative study of fixed tapering dose regimen versus symptom-triggered
regimen of lorazepam for alcohol detoxification. [2014] symptom-triggered regimens of lorazepam for alcohol detoxification... CONCLUSION: Symptom-triggered lorazepam treatment for alcohol withdrawal resulted
A double blind randomised comparison of chlordiazepoxide and lorazepam in alcohol
withdrawal. [2013] withdrawal in a double blind design... CONCLUSION: Lorazepam is more effective than chlordiazepoxide in alcohol
RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics. [2011.10] Early treatment of prolonged seizures with benzodiazepines given intravenously by paramedics in the prehospital setting has been shown to be associated with improved outcomes. However, an increasing number of Emergency Medical System (EMS) protocols use an intramuscular (IM) route because it is faster and consistently achievable...
Clinical Trials Related to Lorazepam
Lorazepam Sedation for Critically Ill Children [Completed]
This clinical trial is being performed under the Best Pharmaceuticals for Children Act,
signed into law in 2002 in order to improve pediatric labeling for off-patent drugs. The
purpose of this study is to make sure that lorazepam, when given to children who are very
sick in the Intensive Care Unit and who are on a breathing machine, is safe and works as
well as a drug called midazolam. Midazolam is already approved by the FDA for this use, but
lorazepam is not, even though both drugs are commonly used for sedation.
ADASUVE-Lorazepam Drug-Drug Interaction [Completed]
This study will compare the safety and effects over time for giving both ADASUVE and
lorazepam (intramuscular) compared to that of each agent given alone.
Exploring the Effects of Diazepam and Lorazepam [Completed]
Aims :
- exploring lorazepam (0. 038 mg/kg) effects, after a single oral intake, in healthy
volunteers, on the neural correlates of encoding and retrieval of information during a
word-stem completion task (implicit memory), using fMRI
- comparing lorazepam effects to diazepam (0. 3 mg/kg)effects
- exploring benzodiazepines effects, after a single oral intake, on the neural correlates
of successful encoding of information within explicit memory using fMRI
Hypothesis :
- both diazepam and lorazepam will impair explicit memory performance, but lorazepam only
will impair perceptual priming
- lorazepam and diazepam will modify the normal correlates of information encoding within
explicit memory
- lorazepam only will alter the neural correlates of perceptual priming
Catatonia in Nodding Syndrome and Lorazepam Treatment [Completed]
Nodding Syndrome is an enigmatic neuropsychiatric syndrome affecting children and
adolescents mostly in Eastern Africa. The symptoms of Nodding Syndrome and catatonia seem to
overlap. The researchers' objectives in this study were to investigate the presence and
types of catatonic symptoms in children with Nodding Syndrome and observe their response to
one or two doses of lorazepam, the first-line treatment for catatonia.
Effect of Additive Lorazepam on Patient Satisfaction as a Premedication in Diagnostic Flexible Bronchoscopy [Recruiting]
Many patients undergoing flexible bronchoscopy (FB) experience anxiety and discomfort during
the procedure. The investigators want to evaluate whether an additional Lorazepam
premedication would improve patient satisfaction for FB.
Reports of Suspected Lorazepam Side Effects
Completed Suicide (230),
Respiratory Arrest (136),
Cardiac Arrest (116),
Toxicity TO Various Agents (103),
Suicide Attempt (78),
Agitation (75),
Somnolence (72),
Delirium (70),
Fall (68),
Poisoning (62), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 11 ratings/reviews, Lorazepam has an overall score of 7.55. The effectiveness score is 7.82 and the side effect score is 7.64. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| Lorazepam review by 51 year old male patient | | Rating |
Overall rating: | |           |
Effectiveness: | | Ineffective |
Side effects: | | No Side Effects | | Treatment Info |
Condition / reason: | | ANXIETY |
Dosage & duration: | | 0.5 MG taken once a day for the period of 1 WEEK |
Other conditions: | | HIGH BLOOD PRESSURE |
Other drugs taken: | | HYZARR AND LIPIDOR | | Reported Results |
Benefits: | | THE BENEFITS WERE NONE. HOWEVER, IT DID NOT CAUSE ME ANY DIFFICULTIES OR SIDE EFFECTS. I APPROVED OF THE IDEA OF TAKING THE MEDICATION TO REDUCE MY GENERAL LOW LEVEL ANXIETY AS AN ADDITIONAL TREATMENT TO LOWERING MY HIGH BLOOD PRESSURE. BUT I EXPERIENCED NO IMPROVEMENTS AT THIS DOSE. |
Side effects: | | THE IDEA WAS TO HELP WITH ANXIETY AS AN AID TO LOWER MY BLOOD PRESSURE. HOWEVER, NEITHER MY BLOOD PRESSURE, WITH ANOTHER MEDICATION, OR THE LEVEL OF ANXIETY WAS REDUCED. THE LORAZEPAM WAS STOPPED AFTER A WEEK WHEN I COMPLAINED OF INEFFECTIVENESS. I DID NOT EXPERIENCE ANY SIDE EFFECTS WITH THIS MEDICATION. |
Comments: | | I WAS TO TAKE THIS MEDICATION ONCE A DAY IN THE MORNING. WHEN I FELT NO BENEFIT I DISCUSSED IT WITH THE DOCTOR WHO SUGGESTED AN INCREASE OF THE DOSAGE. I DECLINED. THE TREATMENT THEORY WAS THAT THE LORAZEPAM WOULD HELP ME WITH ANXIETY AND STRESS WHICH IN TURN WOULD BE AN AID IN ADDITION WITH THE BLOOD PRESSURE MEDICATION TO LOWER MY BLOOD PRESSURE. |
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| Lorazepam review by 45 year old male patient | | Rating |
Overall rating: | |           |
Effectiveness: | | Considerably Effective |
Side effects: | | No Side Effects | | Treatment Info |
Condition / reason: | | Mild sedative |
Dosage & duration: | | 1 mg taken 2 perscriptions for the period of taken when needed |
Other conditions: | | none |
Other drugs taken: | | none | | Reported Results |
Benefits: | | The prescription was given for anxiety and to help with sleep during long flights and when under high anxiety situations. Lorazepam helped to calm and induced drowziness. I would not recomend this if you have to stay alert as it can make functioning dificult. |
Side effects: | | none |
Comments: | | To be taken when needed to relieve stress and assist in sleeping. |
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| Lorazepam review by 52 year old female patient | | Rating |
Overall rating: | |           |
Effectiveness: | | Considerably Effective |
Side effects: | | Severe Side Effects | | Treatment Info |
Condition / reason: | | anxiety |
Dosage & duration: | | 2 mg taken 4 times for the period of about 2 months |
Other conditions: | | headaches |
Other drugs taken: | | ibuprophen | | Reported Results |
Benefits: | | The ativan decreased my anxiety so that I was able to sleep through the night. |
Side effects: | | 2 mg was way too much. After 7 hours of sleep, I continued to be spaced out and clumsy, bumping into walls and dropping things for another 7 hours. My mind also felt really slow, stunned and stupid. These side effects were so strong, my co-workers noticed and were concerned for me. A week later, I took half a pill to ease my anxiety and help me sleep. The side effects were less, but still noticeable by others the next day at work. The last two times I tried ativan, I only took 1/4 of a pill. It did still ease my anxiety and the side effects were mild, but I decided I'd rather live with the anxiety than live with a mind that felt slow and stupid. |
Comments: | | Dissolve one tablet under the tongue at bedtime as needed to a maximum of 3 tablets per week. |
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Page last updated: 2017-09-28
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