and atropine sulfate tablets, USP)
and atropine sulfate oral solution, USP)
Each Lomotil tablet and each 5 ml of Lomotil liquid for oral use contains:
diphenoxylate hydrochloride 2.5 mg
atropine sulfate................. 0.025 mg
Diphenoxylate hydrochloride is an antidiarrheal.
Atropine sulfate is an anticholinergic.
A subtherapeutic amount of atropine sulfate is present to discourage deliberate overdosage.
Lomotil (diphenoxylate/atropine) is indicated for the following:
Lomotil is effective as adjunctive therapy in the management of diarrhea.
Media Articles Related to Lomotil (Diphenoxylate / Atropine)
Probiotics Linked To Lower Risk Of Diarrhea From Antibiotics
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2013.05.31]
Probiotic supplements can prevent or lower the risk of diarrhea caused by antibiotics, according to new research in The Cochrane Library. Scientists from the Cochrane Collaboration suggest that taking probiotics alongside antibiotics can prevent this troublesome side effect. Antibiotics interfere with the beneficial bacteria that live in the gut and permit other dangerous bacteria like C...
Encouraging Results In The Development Of An Oral Vaccine Against Diarrhea
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2013.05.27]
The University of Gothenburg Vaccine Research Institute (GUVAX) announces successful results in a placebo controlled phase I study of an oral, inactivated Escherichia coli diarrhea vaccine...
Antihistamine Meds May Raise Risk for Diarrheal Illness
Source: MedicineNet Clostridium Difficile Colitis Specialty [2013.04.01]
Title: Antihistamine Meds May Raise Risk for Diarrheal Illness
Category: Health News
Created: 3/29/2013 6:35:00 PM
Last Editorial Review: 4/1/2013 12:00:00 AM
Source: MedicineNet Amyloidosis Specialty [2013.02.14]
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 2/14/2013 12:00:00 AM
Diarrhea and Digestive Distress Pictures Slideshow: Problem Foods to Avoid
Source: MedicineNet Gastroesophageal Reflux Disease (GERD) Specialty [2013.02.06]
Title: Diarrhea and Digestive Distress Pictures Slideshow: Problem Foods to Avoid
Created: 2/6/2013 12:00:00 AM
Last Editorial Review: 2/6/2013 12:00:00 AM
Published Studies Related to Lomotil (Diphenoxylate / Atropine)
Pretreatment with Diphenoxylate Hydrochloride/Atropine Sulfate (Lomotil) does not Decrease Physiologic Bowel FDG Activity on PET/CT Scans of the Abdomen and Pelvis. [2009.03]
CONCLUSIONS: Pretreatment with Lomotil prior to PET/CT scanning confers no benefit toward the reduction of physiologic FDG uptake by the small bowel and colon.
Are one or two dangerous? Diphenoxylate-atropine exposure in toddlers. [2008.01]
Lomotil (Pfizer Inc., New York, NY) (diphenoxylate-atropine) is said to be potentially toxic to toddlers with exposure to as little as one to two tablets. A review of the data on diphenoxylate-atropine poisonings from the American Association of Poison Control Centers annual reports, review articles, and case series disputes this view.
Clinical Trials Related to Lomotil (Diphenoxylate / Atropine)
Diphenoxylate / Atropine to Decrease FDG Activity During F-18 FDG PET [Completed]
2-[18F]-fluoro-2-deoxyD-glucose positron emission tomography (FDG PET) has proven to be a
valuable clinical tool for the staging and surveillance of lymphoma. 1-6 Occasionally, lymph
nodes in the mesentery and retroperitoneum can be difficult to distinguish from normal bowel
activity on PET scans despite three-plane and cine maximal image projection (MIP) imaging.
This uncertainty limits the clinical usefulness of PET in some cases of lymphoma. 7-8 In
addition, bowel activity can also hinder interpretation of PET scans in other types of solid
tumors including melanoma and colorectal cancer. 6,9,10 Our goal is to determine how well
diphenoxylate/atropine 5mg/0. 05mg (Lomotil) decreases bowel activity and how this decrease
impacts clinical decision-making, specifically for lymphoma staging and surveillance. This is
a prospective, randomized, double-blinded study involving 60 patients undergoing PET scans
for newly diagnosed or recurrent, untreated lymphoma.
Reports of Suspected Lomotil (Diphenoxylate / Atropine) Side Effects
Chronic Obstructive Pulmonary Disease (23),
Incorrect Dose Administered (6),
Hyponatraemia (6), more >>