LOMOTIL SUMMARY
Lomotil® Cv
(diphenoxylate hydrochloride
and atropine sulfate tablets, USP)
Tablets
(diphenoxylate hydrochloride
and atropine sulfate oral solution, USP)
Liquid
Each Lomotil tablet and each 5 ml of Lomotil liquid for oral use contains:
diphenoxylate hydrochloride 2.5 mg
atropine sulfate................. 0.025 mg
Diphenoxylate hydrochloride is an antidiarrheal.
Atropine sulfate is an anticholinergic.
A subtherapeutic amount of atropine sulfate is present to discourage deliberate overdosage.
Lomotil (diphenoxylate/atropine) is indicated for the following:
Lomotil is effective as adjunctive therapy in the management of diarrhea.
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NEWS HIGHLIGHTSMedia Articles Related to Lomotil (Diphenoxylate / Atropine)
Study Examines Campaign To Increase Use Of Zinc To Prevent Childhood Diarrhea
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2009.11.05]
Scientific American reports on a multiyear PLoS Medicine study, published on Monday, which "followed a nationwide public health campaign to increase zinc use for childhood diarrhea in Bangladesh." "A 10-day course of zinc tablets ...
Also In Global Health News: Breast Cancer In Developing World; Burkina Faso ITN Distribution; Diarrhea In People Over Age Five; Gates Q&A
Source: Breast Cancer News From Medical News Today [2009.11.04]
Researchers Highlight 'Troubling Increase' In Breast Cancer In Developing Countries "International cancer specialists meet this week to plan an assault on a troubling increase of breast cancer in developing countries, where nearly two-thirds of women aren't diagnosed until it has spread through their bodies," the Associated Press reports.
New Research Reveals The Cause Of Common Chronic Diarrhea
Source: Endocrinology News From Medical News Today [2009.11.03]
A common type of chronic diarrhoea may be caused by a hormone deficiency, according to new research published in the November issue of Clinical Gastroenterology and Hepatology.
What Is Diarrhea? What Causes Diarrhea?
Source: Irritable-Bowel Syndrome News From Medical News Today [2009.07.23]
Diarrhea is the frequent passing of loose or watery stools. Acute diarrhea, which is a common cause of death in developing countries, appears rapidly and may last from five to ten days. Chronic diarrhea lasts much longer and is the second cause of childhood death in the developing world. Diarrhea is sometimes accompanied by abdominal cramps or fever.
New Insights Could Help Shield Babies From Diarrhea Bug
Source: MedicineNet Gastroenteritis Specialty [2009.07.17]
Title: New Insights Could Help Shield Babies From Diarrhea Bug
Category: Health News
Created: 7/17/2009 7:00:00 AM
Last Editorial Review: 7/17/2009
Published Studies Related to Lomotil (Diphenoxylate / Atropine)
Pretreatment with Diphenoxylate Hydrochloride/Atropine Sulfate (Lomotil) does not Decrease Physiologic Bowel FDG Activity on PET/CT Scans of the Abdomen and Pelvis. [2009.03]
CONCLUSIONS: Pretreatment with Lomotil prior to PET/CT scanning confers no benefit toward the reduction of physiologic FDG uptake by the small bowel and colon.
Are one or two dangerous? Diphenoxylate-atropine exposure in toddlers. [2008.01]
Lomotil (Pfizer Inc., New York, NY) (diphenoxylate-atropine) is said to be potentially toxic to toddlers with exposure to as little as one to two tablets. A review of the data on diphenoxylate-atropine poisonings from the American Association of Poison Control Centers annual reports, review articles, and case series disputes this view.
Clinical Trials Related to Lomotil (Diphenoxylate / Atropine)
Diphenoxylate / Atropine to Decrease FDG Activity During F-18 FDG PET [Completed]
2-[18F]-fluoro-2-deoxyD-glucose positron emission tomography (FDG PET) has proven to be a
valuable clinical tool for the staging and surveillance of lymphoma. 1-6 Occasionally, lymph
nodes in the mesentery and retroperitoneum can be difficult to distinguish from normal bowel
activity on PET scans despite three-plane and cine maximal image projection (MIP) imaging.
This uncertainty limits the clinical usefulness of PET in some cases of lymphoma. 7-8 In
addition, bowel activity can also hinder interpretation of PET scans in other types of solid
tumors including melanoma and colorectal cancer. 6,9,10 Our goal is to determine how well
diphenoxylate/atropine 5mg/0. 05mg (Lomotil) decreases bowel activity and how this decrease
impacts clinical decision-making, specifically for lymphoma staging and surveillance. This is
a prospective, randomized, double-blinded study involving 60 patients undergoing PET scans
for newly diagnosed or recurrent, untreated lymphoma.
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