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Lomotil (Diphenoxylate Hydrochloride / Atropine Sulfate) - Summary



LOMOTIL (DIPHENOXYLATE/ATROPINE) contains diphenoxylate hydrochloride, an antidiarrheal and atropine sulfate, an anticholinergic.

LOMOTIL (DIPHENOXYLATE/ATROPINE) is indicated for the following:

Lomotil is effective as adjunctive therapy in the management of diarrhea.

See all Lomotil indications & dosage >>


Media Articles Related to Lomotil (Diphenoxylate / Atropine)

Chronic Diarrhea: Diagnosis and Management
Source: Medscape Allergy & Clinical Immunology Headlines [2017.02.24]
There are many diverse causes of chronic diarrhea. Learn when imaging studies or other diagnostic test are appropriate, and how management should be approached, in this primer.
Clinical Gastroenterology and Hepatology

IBS-D (Irritable Bowel Syndrome with Diarrhea)
Source: MedicineNet Constipation Specialty [2017.01.27]
Title: IBS-D (Irritable Bowel Syndrome with Diarrhea)
Category: Diseases and Conditions
Created: 8/10/2016 12:00:00 AM
Last Editorial Review: 1/27/2017 12:00:00 AM

When to Call the Doctor for Fever, Nausea, Diarrhea, Colds, and Coughs
Source: MedicineNet Bruises Specialty [2016.12.01]
Title: When to Call the Doctor for Fever, Nausea, Diarrhea, Colds, and Coughs
Category: Doctor's & Expert's views on Symptoms
Created: 12/20/2010 12:00:00 AM
Last Editorial Review: 12/1/2016 12:00:00 AM

Addicts Using Diarrhea Drug Imodium to Get High
Source: MedicineNet Poison Control Centers Specialty [2016.05.06]
Title: Addicts Using Diarrhea Drug Imodium to Get High
Category: Health News
Created: 5/5/2016 12:00:00 AM
Last Editorial Review: 5/6/2016 12:00:00 AM

Travelers' Diarrhea
Source: MedicineNet Giardia Lamblia Specialty [2016.03.16]
Title: Travelers' Diarrhea
Category: Diseases and Conditions
Created: 4/3/1999 12:00:00 AM
Last Editorial Review: 3/16/2016 12:00:00 AM

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Published Studies Related to Lomotil (Diphenoxylate / Atropine)

Pretreatment with Diphenoxylate Hydrochloride/Atropine Sulfate (Lomotil) does not Decrease Physiologic Bowel FDG Activity on PET/CT Scans of the Abdomen and Pelvis. [2009.03]
CONCLUSIONS: Pretreatment with Lomotil prior to PET/CT scanning confers no benefit toward the reduction of physiologic FDG uptake by the small bowel and colon.

Are one or two dangerous? Diphenoxylate-atropine exposure in toddlers. [2008.01]
Lomotil (Pfizer Inc., New York, NY) (diphenoxylate-atropine) is said to be potentially toxic to toddlers with exposure to as little as one to two tablets. A review of the data on diphenoxylate-atropine poisonings from the American Association of Poison Control Centers annual reports, review articles, and case series disputes this view.

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Clinical Trials Related to Lomotil (Diphenoxylate / Atropine)

Diphenoxylate / Atropine to Decrease FDG Activity During F-18 FDG PET [Completed]
2-[18F]-fluoro-2-deoxyD-glucose positron emission tomography (FDG PET) has proven to be a valuable clinical tool for the staging and surveillance of lymphoma. 1-6 Occasionally, lymph nodes in the mesentery and retroperitoneum can be difficult to distinguish from normal bowel activity on PET scans despite three-plane and cine maximal image projection (MIP) imaging. This uncertainty limits the clinical usefulness of PET in some cases of lymphoma. 7-8 In addition, bowel activity can also hinder interpretation of PET scans in other types of solid tumors including melanoma and colorectal cancer. 6,9,10 Our goal is to determine how well diphenoxylate/atropine 5mg/0. 05mg (Lomotil) decreases bowel activity and how this decrease impacts clinical decision-making, specifically for lymphoma staging and surveillance. This is a prospective, randomized, double-blinded study involving 60 patients undergoing PET scans for newly diagnosed or recurrent, untreated lymphoma.

more trials >>

Reports of Suspected Lomotil (Diphenoxylate / Atropine) Side Effects

Chronic Obstructive Pulmonary Disease (23)Emphysema (23)Amnesia (22)Bedridden (21)Diarrhoea (17)Nausea (8)Syncope (7)Fatigue (6)Incorrect Dose Administered (6)Hyponatraemia (6)more >>

Page last updated: 2017-02-24

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