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Lomotil (Diphenoxylate Hydrochloride / Atropine Sulfate) - Summary



LOMOTIL (DIPHENOXYLATE/ATROPINE) contains diphenoxylate hydrochloride, an antidiarrheal and atropine sulfate, an anticholinergic.

LOMOTIL (DIPHENOXYLATE/ATROPINE) is indicated for the following:

Lomotil is effective as adjunctive therapy in the management of diarrhea.

See all Lomotil indications & dosage >>


Media Articles Related to Lomotil (Diphenoxylate / Atropine)

Rotavirus vaccines continue to reduce diarrhea hospitalizations, medical costs in US kids
Source: Immune System / Vaccines News From Medical News Today [2017.08.14]
Following the introduction of routine childhood vaccination against rotavirus, a common cause of diarrheal illness, more than 380,000 children avoided hospitalization for diarrhea from 2008 to 2013...

Six foods that cause diarrhea
Source: Nutrition / Diet News From Medical News Today [2017.08.11]
In this article, learn about six foods that may contribute to diarrhea and how to tell if diarrhea is due to food. What treatments are recommended?

BRAT diet: Benefits, risks, and treating diarrhea
Source: Flu / Cold / SARS News From Medical News Today [2017.07.07]
What is the BRAT diet, how does the BRAT diet work, and is it effective? Learn if the diet is safe, when to see a doctor, and what foods to avoid.

Source: MedicineNet Addison Disease Specialty [2017.03.21]
Title: Diarrhea
Category: Symptoms and Signs
Created: 10/13/2003 12:00:00 AM
Last Editorial Review: 3/21/2017 12:00:00 AM

HIV and diarrhea: Causes, treatment, and remedies
Source: Irritable Bowel Syndrome News From Medical News Today [2017.03.12]
What is the connection between diarrhea and HIV, when might it occur, and how long does it last? Are there any complications with HIV and diarrhea?

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Published Studies Related to Lomotil (Diphenoxylate / Atropine)

Pretreatment with Diphenoxylate Hydrochloride/Atropine Sulfate (Lomotil) does not Decrease Physiologic Bowel FDG Activity on PET/CT Scans of the Abdomen and Pelvis. [2009.03]
CONCLUSIONS: Pretreatment with Lomotil prior to PET/CT scanning confers no benefit toward the reduction of physiologic FDG uptake by the small bowel and colon.

Are one or two dangerous? Diphenoxylate-atropine exposure in toddlers. [2008.01]
Lomotil (Pfizer Inc., New York, NY) (diphenoxylate-atropine) is said to be potentially toxic to toddlers with exposure to as little as one to two tablets. A review of the data on diphenoxylate-atropine poisonings from the American Association of Poison Control Centers annual reports, review articles, and case series disputes this view.

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Clinical Trials Related to Lomotil (Diphenoxylate / Atropine)

Diphenoxylate / Atropine to Decrease FDG Activity During F-18 FDG PET [Completed]
2-[18F]-fluoro-2-deoxyD-glucose positron emission tomography (FDG PET) has proven to be a valuable clinical tool for the staging and surveillance of lymphoma. 1-6 Occasionally, lymph nodes in the mesentery and retroperitoneum can be difficult to distinguish from normal bowel activity on PET scans despite three-plane and cine maximal image projection (MIP) imaging. This uncertainty limits the clinical usefulness of PET in some cases of lymphoma. 7-8 In addition, bowel activity can also hinder interpretation of PET scans in other types of solid tumors including melanoma and colorectal cancer. 6,9,10 Our goal is to determine how well diphenoxylate/atropine 5mg/0. 05mg (Lomotil) decreases bowel activity and how this decrease impacts clinical decision-making, specifically for lymphoma staging and surveillance. This is a prospective, randomized, double-blinded study involving 60 patients undergoing PET scans for newly diagnosed or recurrent, untreated lymphoma.

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Reports of Suspected Lomotil (Diphenoxylate / Atropine) Side Effects

Chronic Obstructive Pulmonary Disease (23)Emphysema (23)Amnesia (22)Bedridden (21)Diarrhoea (17)Nausea (8)Syncope (7)Fatigue (6)Incorrect Dose Administered (6)Hyponatraemia (6)more >>

Page last updated: 2017-08-14

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