Cardiovascular Risk
- NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction (MI), and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. (See WARNINGS and CLINICAL TRIALS.)
- Lodine is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery. (See WARNINGS.)
Gastrointestinal Risk
- NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal (GI) events. (See WARNINGS.)
|
| |
LODINE SUMMARY
Lodine®
(etodolac capsules 200 and 300 mg, and etodolac tablets 400 and 500 mg)
Lodine® (etodolac) is a member of the pyranocarboxylic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Each tablet and capsule contains etodolac for oral administration. Etodolac is a racemic mixture of [+]S and [-]R-enantiomers. Etodolac is a white crystalline compound, insoluble in water but soluble in alcohols, chloroform, dimethyl sulfoxide, and aqueous polyethylene glycol.
Carefully consider the potential benefits and risks of Lodine and other treatment options before deciding to use Lodine. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).
Lodine (etodolac capsules and tablets) is indicated:
- For acute and long-term use in the management of signs and symptoms of the following:
- Rheumatoid arthritis
For the management of acute pain
|
|
NEWS HIGHLIGHTS
Published Studies Related to Lodine (Etodolac)
A multicentric, randomized, comparative clinical trial to evaluate the efficacy and safety of S-etodolac in the treatment of osteoarthritis in Indian patients. [2010.07]
OBJECTIVE: To compare the efficacy and safety of S-etodolac with etodolac in the treatment of osteoarthritis in Indian patients... CONCLUSION: The present study has established the efficacy, tolerability and safety of S-etodolac extended release tablets in the treatment of osteoarthritis in Indian patients.
Efficacy and safety of etodolac-paracetamol fixed dose combination in patients
with knee osteoarthritis flare-up: a randomized, double-blind comparative
evaluation. [2010]
OBJECTIVE: To evaluate the efficacy and safety of etodolac-paracetamol
combination in comparison with etodolac alone in patients with knee
osteoarthritis (OA) flare-up. METHODS: In this double-blind, double-dummy, randomized, comparative,
multicentric, parallel group study, 220 patients of either sex in the age range
of 40 to 70 years with an OA flare-up were randomized either to etodolac (300
mg)-paracetamol (500 mg) combination or etodolac (300 mg) alone twice a day for
10 days...
A multicentric, randomized, comparative clinical trial to evaluate the efficacy
and safety of S-etodolac in the treatment of osteoarthritis in Indian patients. [2010]
treatment of osteoarthritis in Indian patients... CONCLUSION: The present study has established the efficacy, tolerability and
Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs. [2007.03]
OBJECTIVE: To evaluate adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs... Monitoring for adverse effects should be considered when nonsteroidal anti-inflammatory drugs are used to treat dogs with chronic pain.
Etodolac versus dexamethasone effect in reduction of postoperative symptoms following surgical endodontic treatment: a double-blind study. [2006.06]
OBJECTIVE: The purpose of this prospective study was to analyze the effect of etodolac versus dexamethasone in reducing postoperative pain in patients who had surgical endodontic treatment using a strict protocol... CONCLUSION: Postoperative pain following endodontic surgical treatment is not uncommon. Etodolac as well as dexamethasone might serve as a pain relief measure for postoperative pain in these patients.
Clinical Trials Related to Lodine (Etodolac)
MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Ankle Sprains [Recruiting]
Safety and Efficacy of SDX-101 (R-Etodolac) in Patients With Relapsed or Refractory Multiple Myeloma (MM) [Terminated]
An Open Label, Multi-Center, Phase II Study to Investigate the Safety and Efficacy of SDX-101
(R-Etodolac) in Patients with Relapsed or Refractory Multiple Myeloma (MM)
A Study to Verify the Efficacy of YM177 (Celecoxib) in Postoperative Pain Patients [Recruiting]
Aim of the study is to compare efficacy and safety of YM177 with placebo and etodolac in
patients with postoperative pain.
MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Tendonitis and Bursitis of the Shoulder [Recruiting]
Safety and Efficacy of SDX-101 (R-Etodolac) in Combination With Chlorambucil, and That of Chlorambucil Alone, in Patients With Chronic Lymphocytic Leukemia (CLL) [Terminated]
This is a Phase 2, multi-center, open label, randomized clinical study to evaluate the safety
and efficiency of SDX-101 in combination with chlorambucil (CLB) and chlorambucil alone in
Chronic Lymphocytic Leukaemia (CLL) patients. The study treatment period will be
approximately 24-26 weeks with a follow-up period of approximately 8 weeks. Following the end
of treatment, patients with a confirmed complete response, partial response or stable disease
will be followed for up to 2 years to assess time to disease progression. Approximately 80
patients with documented diagnosis of B-cell CLL by standard clinical and immunophenotyping
criteria will be enrolled into the SDX-101-03 study. This study is being conducted in the
following European countries: France, Germany, Poland, Sweden and the United Kingdom.
Reports of Suspected Lodine (Etodolac) Side Effects
Drug Hypersensitivity (4),
Pain (3),
Drug Rash With Eosinophilia and Systemic Symptoms (3),
Asthma (2),
Bradypnoea (2),
Drug Ineffective (2),
Drug Level Increased (2),
Orthostatic Hypotension (2),
Fall (2),
Multiple Drug Overdose Intentional (2), more >>
|
PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Lodine has an overall score of 1. The effectiveness score is 4 and the side effect score is 4. The scores are on ten point scale: 10 - best, 1 - worst.
| | Lodine review by 54 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | pain |
| Dosage & duration: | | 400mg taken twice a day for the period of 10 days |
| Other conditions: | | extreme diarrhea, upset stomach |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | mild pain reduction in arm/wrist |
| Side effects: | | extreme diarrhea, upset stomach, nausua |
| Comments: | | My DO prescirbed this pain med to reduce pain in my right arm/wrist from a car accident.
I had tried 3 massage visits with a medical massage therapist that only temporarily relieved the pain. So after trying the massage thearpy, my doctor precribed this pain medication. |
|
|
|
Page last updated: 2013-02-10
|
