LODINE SUMMARY
Etodolac is a member of the pyranocarboxylic acid group of
non-steroidal anti-inflammatory drugs (NSAIDs). Each capsule contains etodolac
for oral administration. Etodolac is a racemic mixture of [+]S and
[-]R-enantiomers. Etodolac is a white crystalline compound, insoluble in water
but soluble in alcohols, chloroform, dimethyl sulfoxide, and aqueous
polyethylene glycol.
Carefully consider the potential benefits and risks of etodolac
capsules and other treatment options before deciding to use etodolac capsules.
Use the lowest effective dose for the shortest duration consistent with
individual patient treatment goals (see WARNINGS).
Etodolac capsules are indicated:
- For acute and long-term use in the management of signs and symptoms of the
following:
- Rheumatoid arthritis
- For the management of acute pain
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NEWS HIGHLIGHTS
Published Studies Related to Lodine (Etodolac)
A multicentric, randomized, comparative clinical trial to evaluate the efficacy and safety of S-etodolac in the treatment of osteoarthritis in Indian patients. [2010.07] OBJECTIVE: To compare the efficacy and safety of S-etodolac with etodolac in the treatment of osteoarthritis in Indian patients... CONCLUSION: The present study has established the efficacy, tolerability and safety of S-etodolac extended release tablets in the treatment of osteoarthritis in Indian patients.
Efficacy and safety of etodolac-paracetamol fixed dose combination in patients
with knee osteoarthritis flare-up: a randomized, double-blind comparative
evaluation. [2010] OBJECTIVE: To evaluate the efficacy and safety of etodolac-paracetamol
combination in comparison with etodolac alone in patients with knee
osteoarthritis (OA) flare-up. METHODS: In this double-blind, double-dummy, randomized, comparative,
multicentric, parallel group study, 220 patients of either sex in the age range
of 40 to 70 years with an OA flare-up were randomized either to etodolac (300
mg)-paracetamol (500 mg) combination or etodolac (300 mg) alone twice a day for
10 days...
A multicentric, randomized, comparative clinical trial to evaluate the efficacy
and safety of S-etodolac in the treatment of osteoarthritis in Indian patients. [2010] treatment of osteoarthritis in Indian patients... CONCLUSION: The present study has established the efficacy, tolerability and
Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs. [2007.03] OBJECTIVE: To evaluate adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs... Monitoring for adverse effects should be considered when nonsteroidal anti-inflammatory drugs are used to treat dogs with chronic pain.
Etodolac versus dexamethasone effect in reduction of postoperative symptoms following surgical endodontic treatment: a double-blind study. [2006.06] OBJECTIVE: The purpose of this prospective study was to analyze the effect of etodolac versus dexamethasone in reducing postoperative pain in patients who had surgical endodontic treatment using a strict protocol... CONCLUSION: Postoperative pain following endodontic surgical treatment is not uncommon. Etodolac as well as dexamethasone might serve as a pain relief measure for postoperative pain in these patients.
Clinical Trials Related to Lodine (Etodolac)
Bioequivalence Study of Etodolac Extended Release Tablets USP 600mg Under Fed Condition [Completed]
This is a open Label, balanced, randomized, single dose, two-treatment, two-sequence,
two-period, crossover, oral pivotal bioequivalence study. The purpose of this study is to
assess the bioequivalence between Test Product and the corresponding Reference Product under
fed condition in healthy, adult human subjects.
Bioequivalence Study of Etodolac Extended Release Tablets USP 600mg Under Fasting Condition [Completed]
This is a open Label, balanced, randomized, single dose, two-treatment, two-sequence,
two-period, crossover, oral pivotal bioequivalence study. The purpose of this study is to
assess the bioequivalence between Test Product and the corresponding Reference Product under
fasting condition in healthy, adult human subjects.
Bioequivalence Study of Etodolac Capsules USP 300 mg Under Fed Condition [Completed]
This is a open Label, balanced, randomized, single dose, two-treatment, two-sequence,
two-period, crossover pivotal study. The purpose of this study is to assess the
bioequivalence between Test Product and the corresponding Reference Product under fed
condition in healthy, adult human subjects.
Bioequivalence Study of Etodolac Capsules USP 300 mg Under Fasting Condition [Completed]
This is a open Label, balanced, randomized, single dose, two-treatment, two-sequence,
two-period, crossover pivotal study. The purpose of this study is to assess the
bioequivalence between Test Product and the corresponding Reference Product under fasting
condition in healthy, adult human subjects.
Bioequivalence Study of Etodolac Tablet USP 500 mg Under Fed Condition [Completed]
This is a open Label, balanced, randomized, single dose, two-treatment, two-sequence,
two-period, crossover pivotal study. The purpose of this study is to assess the
bioequivalence between Test Product and the corresponding Reference Product under fed
condition in healthy, adult human subjects.
Reports of Suspected Lodine (Etodolac) Side Effects
Drug Hypersensitivity (4),
Pain (3),
Drug Rash With Eosinophilia and Systemic Symptoms (3),
Asthma (2),
Bradypnoea (2),
Drug Ineffective (2),
Drug Level Increased (2),
Orthostatic Hypotension (2),
Fall (2),
Multiple Drug Overdose Intentional (2), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Lodine has an overall score of 1. The effectiveness score is 4 and the side effect score is 4. The scores are on ten point scale: 10 - best, 1 - worst.
| Lodine review by 54 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Marginally Effective |
Side effects: | | Severe Side Effects | | Treatment Info |
Condition / reason: | | pain |
Dosage & duration: | | 400mg taken twice a day for the period of 10 days |
Other conditions: | | extreme diarrhea, upset stomach |
Other drugs taken: | | none | | Reported Results |
Benefits: | | mild pain reduction in arm/wrist |
Side effects: | | extreme diarrhea, upset stomach, nausua |
Comments: | | My DO prescirbed this pain med to reduce pain in my right arm/wrist from a car accident.
I had tried 3 massage visits with a medical massage therapist that only temporarily relieved the pain. So after trying the massage thearpy, my doctor precribed this pain medication. |
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Page last updated: 2013-02-10
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