NEWS HIGHLIGHTS
Published Studies Related to Locoid Lipocream (Hydrocortisone Topical)
Randomized controlled trial comparing the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in the treatment of vitiligo of the face and neck. [2008.11]
BACKGROUND: Vitiligo is a pigmentary disorder which may have disfiguring consequences. Its treatment remains a challenge. OBJECTIVES: We designed a parallel-group randomized controlled trial to compare the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in patients with vitiligo unresponsive to previous treatment with topical steroids or narrow-band ultraviolet (UV) B phototherapy... CONCLUSIONS: Recalcitrant vitiligo of the face and neck may benefit from the combination of excimer laser phototherapy with topical hydrocortisone 17-butyrate cream.
Randomized controlled trial comparing the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in the treatment of vitiligo of the face and neck. [2008.08.19]
Background Vitiligo is a pigmentary disorder which may have disfiguring consequences... Conclusions Recalcitrant vitiligo of the face and neck may benefit from the combination of excimer laser phototherapy with topical hydrocortisone 17-butyrate cream.
1% Hydrocortisone ointment is an effective treatment of pruritus ani: a pilot randomized controlled crossover trial. [2007.12]
BACKGROUND: Pruritus ani (PA) is a common condition which is difficult to treat in the absence of obvious predisposing factors. There is paucity of evidence-based guidelines on the treatment of this condition. We examined whether 1% hydrocortisone ointment is an effective treatment for PA... CONCLUSION: A short course of mild steroid ointment is an effective treatment for PA.
The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study. [2007.02]
BACKGROUND: While many studies have demonstrated the efficacy and safety of tacrolimus ointment in the treatment of atopic dermatitis (AD), only a few have investigated the effects of tacrolimus on inflammatory cells and their cytokine gene expression in patients with AD. OBJECTIVES: To characterize further the immunophenotype of infiltrating cells and the production of certain cytokines before and after treatment with topical tacrolimus and hydrocortisone butyrate... CONCLUSIONS: Tacrolimus not only inhibits T-lymphocyte proliferation and cytokine production, but also plays an important role in the IL-12-induced shift from a T-helper (Th) 2 to a Th1 cytokine profile that characterizes the development of chronic AD. Tacrolimus also demonstrates wider pharmacodynamic effects than hydrocortisone.
Expression of adhesion molecules in atopic dermatitis is reduced by tacrolimus, but not by hydrocortisone butyrate: a randomized immunohistochemical study. [2006.11]
Topical tacrolimus represents an effective and well-tolerated treatment for atopic dermatitis (AD). Its known effects include reduced production of proinflammatory cytokines and reduced chemokine gradient...
Clinical Trials Related to Locoid Lipocream (Hydrocortisone Topical)
Adherence to Topical Hydrocortisone 17-Butyrate 0.1% (LocoidŽ) Using Different Vehicles in Adults With Atopic Dermatitis [Active, not recruiting]
The purpose of this research study is to better understand how the study drug Locoid works
when people use it to treat atopic dermatitis.
Cortisol Control of Human Inflammatory Responses to Endotoxin [Completed]
The purpose of the research is to study a common and dangerous medical condition called
'septic shock' that often occurs in critically ill patients. In order to learn about septic
shock in humans, we will administer a substance called 'endotoxin' to participants in this
study. Endotoxin causes a temporary period of inflammation in the human body, a brief
'virtual' infection. This is an established method for the investigation of inflammation
properties. We are interested in how the natural hormone, cortisol, can affect the human
response to endotoxin. We know that when cortisol is given at the same time as endotoxin it
can decrease the inflammation that occurs due to endotoxin. In this study we will test
whether or not cortisol, when given the day before the endotoxin, will work to change the
inflammation that occurs due to endotoxin. In order to test this, two-thirds of the study
participants will receive cortisol on the day before they receive the endotoxin and one-third
of the study participants will receive a placebo (no medication) before the endotoxin.
Efficacy Study of Low-Dose Hydrocortisone Treatment for Fibromyalgia [Completed]
This study is based on clinical findings that some patients with fibromyalgia have a tendency
towards lower levels of the stress hormone cortisol. The hypothesis to be tested in this
study is that the administration of a very low-dose of cortisol which has no side effects
corrects this deficiency and results in an improvement of symptoms
Correlation Salivary Cortisol and Free Serum Cortisol to Total Serum Cortisol in MICU Septic Shock [Recruiting]
The purpose of the study is:
- to correlate salivary cortisol to free serum cortisol (as salivary cortisol is
considered to be almost complete free cortisol) and,
- to correlate free serum cortisol to total serum cortisol levels
Both in patients with septic shock (severe sepsis requiring vasopressors).
We believe that:
- total serum cortisol does not correlate with free serum cortisol in patient with septic
shock and,
- that salivary cortisol correlates with free serum cortisol and can be used to determine
the level of free serum cortisol.
Ketoconazole, Hydrocortisone and Dutasteride in Asymptomatic Hormone Refractory Prostate Cancer [Active, not recruiting]
The combination of ketaconazole and hydrocortisone is commonly used for the treatment of
prostate cancer. The purpose of this study is to determine if the addition of a drug called
dutasteride to this approved combination will make the combination more effective in treating
prostate cancer.
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