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Livalo (Pitavastatin Calcium) - Summary

 
 



LIVALO SUMMARY

LIVALO (pitavastatin) is an inhibitor of HMG-CoA reductase. It is a synthetic lipid-lowering agent for oral administration.

LIVALO (pitavastatin) is a HMG-CoA reductase inhibitor indicated for:

  • Patients with primary hyperlipidemia and mixed dyslipidemia as an adjunctive therapy to diet to reduce elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C)

Limitations of Use:

  • Doses of LIVALO greater than 4 mg once daily were associated with an increased risk for severe myopathy in premarketing clinical studies. Do not exceed 4 mg once daily dosing of LIVALO.
  • The effect of LIVALO on cardiovascular morbidity and mortality has not been determined
  • LIVALO has not been studied in patients with severe renal impairment (glomerular filtration rate < 30 mL/min/1.73 m2), not yet on hemodialysis. LIVALO should not be used in this patient population.
  • LIVALO has not been studied with the protease inhibitor combination lopinavir/ritonavir. LIVALO should not be used with this combination of protease inhibitors
  • LIVALO has not been studied in Fredrickson Type I, III, and V dyslipidemias

See all Livalo indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Livalo (Pitavastatin)

Pitavastatin and Atorvastatin double-blind randomized comPArative study among hiGh-risk patients, including thOse with Type 2 diabetes mellitus, in Taiwan (PAPAGO-T Study). [2013]
CONCLUSION: Both pitavastatin (2 mg/day) and atorvastatin (10 mg/day) were well

Comparative efficacy of pitavastatin and simvastatin in high-risk patients: a randomized controlled trial. [2011.09]
INTRODUCTION: Despite the proven efficacy of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) in lowering total and low-density lipoprotein cholesterol (LDL-C), many patients do not reach recommended lipid targets. This study compared pitavastatin, a new and highly effective statin, and simvastatin in patients at high risk of coronary heart disease (CHD). The primary objective was to demonstrate noninferiority of pitavastatin to simvastatin... CONCLUSION: Pitavastatin 4 mg is as effective as simvastatin 40 mg in lowering LDL-C in dyslipidemic patients at high risk of CHD, with additional effects on HDL-C and triglycerides. Therefore, pitavastatin may be appropriate for the management of dyslipidemic patients at high cardiovascular risk.

The effect of pitavastatin calcium on endothelial dysfunction induced by hypercholesterolemia. [2011.07]
OBJECTIVE: To investigate whether endothelial function can be improved by the treatment of pitavastatin calcium via its antioxidant properties in hypercholesteremia patients... CONCLUSIONS: Endothelial dysfunction induced by hypercholesteremia can be ameliorated by pitavastatin calcium treatment, which occurs in part through its antioxidative properties. (c) 2011 Informa UK, Ltd.

Distinct effects of pitavastatin and atorvastatin on lipoprotein subclasses in patients with Type 2 diabetes mellitus. [2011.07]
AIMS: Effects of pitavastatin and atorvastatin on the lipid profile and lipoprotein subclasses were compared in patients with Type 2 diabetes with dyslipidaemia... CONCLUSIONS: The impact on lipoprotein subclass profiles was different between pitavastatin and atorvastatin. It may be beneficial to determine lipoprotein subclass profile and select the appropriate statin for each profile in patients with diabetes with an additional cardiovascular risk such as low HDL cholesterol or hypertriglyceridaemia. (c) 2011 The Authors. Diabetic Medicine (c) 2011 Diabetes UK.

Pitavastatin prevents postprandial endothelial dysfunction via reduction of the serum triglyceride level in obese male subjects. [2011.07]
Obesity is a well-established risk factor for the development and progression of coronary heart disease. Moreover, endothelial dysfunction is an early event in atherosclerosis and is known to be associated with postprandial hypertriglyceridemia... Pitavastatin might prevent endothelial dysfunction caused by postprandial hypertriglyceridemia within 2 weeks of therapy in obese subjects.

more studies >>

Clinical Trials Related to Livalo (Pitavastatin)

Efficacy and Safety Study of Pitavastatin Compared to atoRvastatin in Type 2 dIabeTes Mellitus With Hypercholesterolemia [Recruiting]
A randomized, open label, dose titration study to evaluate the efficacy and safety of Pitavastatin compared to atorvastatin in Type 2 Diabetes Mellitus with hypercholesterolemia

Differential Intervention Trial by Standard Therapy Versus Pitavastatin in Patients With Chronic Hemodialysis (DIALYSIS) [Recruiting]
The purpose of this study is to verify whether pitavastatin prevents from cardiovascular events and improves the mortality in chronic hemodialysis patients with hypercholesteremia.

Pitavastatin Pre-Treatment Study in Patient With Elective PCI for Stable Angina Pectoris (PIPA) [Recruiting]
Patients who is scheduled elective PCI are randomized to pitavastatin 4mg daily or without

pitavastatin for 5 - 7days before the procedure. Creatine kinase-MB, troponin I, and

myoglobin levels are measured at baseline and at 8 and 24 hours after the procedure(1st evaluation). After PCI, pitavastatin will be administered for additional 4 weeks(2nd evaluation).

Efficacy, Safety of Coadministered Pitavastatin and Valsartan in Patients With Hypertension and Dyslipidemia [Recruiting]

A 12-Week Study Comparing Pitavastatin 4 mg vs. Pravastatin 40 mg in HIV-Infected Subjects [Recruiting]

more trials >>

Reports of Suspected Livalo (Pitavastatin) Side Effects

Rhabdomyolysis (28)Myalgia (21)Blood Creatine Phosphokinase Increased (17)Back Pain (12)Pain in Extremity (10)Liver Disorder (9)Alanine Aminotransferase Increased (9)Arthralgia (9)Aspartate Aminotransferase Increased (9)Hepatic Function Abnormal (8)more >>


Page last updated: 2014-11-30

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