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Lithium Citrate (Lithium Citrate) - Summary

 



WARNING

Lithium toxicity is closely related to serum lithium levels, and can occur at doses close to therapeutic levels. Facilities for prompt and accurate serum lithium determinations should be available before initiating therapy (see DOSAGE AND ADMINISTRATION).

 

SUMMARY

LITHIUM CITRATE SYRUP, USP

Lithium Citrate Syrup, USP is a palatable oral dosage form of lithium ion, with a raspberry flavor. Lithium citrate is prepared in solution from lithium hydroxide and citric acid in a ratio approximating di-lithium citrate. Each 5 mL of Lithium Citrate Syrup, USP contains 8 mEq of lithium ion (Li+), equivalent to the amount of lithium in 300 mg of lithium carbonate and alcohol 0.3% v/v.

Lithium citrate is indicated in the treatment of manic episodes of Bipolar Disorder. Bipolar Disorder, Manic (DSM III) is equivalent to Manic Depressive Illness, Manic, in the older DSM-II terminology.

Lithium is also indicated as a maintenance treatment for individuals with a diagnosis of Bipolar Disorder. Maintenance therapy reduces the frequency of manic episodes and diminishes the intensity of those episodes which may occur.

Typical symptoms of mania include pressure of speech, motor hyperactivity, reduced need for sleep, flight of ideas, grandiosity, elation, poor judgement, aggressiveness, and possibly hostility. When given to a patient experiencing a manic episode, lithium may produce a normalization of symptomatology within 1 to 3 weeks.


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NEWS HIGHLIGHTS

Media Articles Related to Lithium Citrate (Lithium)

Researchers Test Lithium as Radiation Protector
Source: MedicineNet lithium Specialty [2009.04.02]
Title: Researchers Test Lithium as Radiation Protector
Category: Health News
Created: 4/2/2009 2:00:00 AM
Last Editorial Review: 4/2/2009

Funding Supports ADA Technologies' Development Of Home Monitor For Bipolar Disorder
Source: Bipolar News From Medical News Today [2009.10.28]
ADA Technologies, Inc. (ADA) received a $189,886 grant from the National Institute of Mental Health to develop a home lithiummonitor for use by patients with bipolar disorder. The testing tool would allow reliable, routine at-home monitoring of blood lithium concentrations, enabling individuals with bipolar disorder to conveniently and effectively manage their care. Effective treatment of bipolar disorder, an inherited disease that affects 5.

Bipolar Disorder (Mania)
Source: MedicineNet aripiprazole Specialty [2009.08.13]
Title: Bipolar Disorder (Mania)
Category: Diseases and Conditions
Created: 1/13/2003
Last Editorial Review: 8/13/2009

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Published Studies Related to Lithium Citrate (Lithium)

Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study. [2009.06]
CONCLUSIONS: The current results do not support the notion that lithium treatment may lead to reduced hyperphosphorylation of tau protein after a short 10-week treatment in the Alzheimer's disease target population. TRIAL REGISTRATION: (Controlled-Trials.com) Identifier: ISRCTN72046462. Copyright 2009 Physicians Postgraduate Press, Inc.

Comparison between lithium dilution and pulse contour analysis techniques for cardiac output measurement in isoflurane anaesthetized ponies: influence of different inotropic drugs. [2009.05]
OBJECTIVE: To compare cardiac output () measurements using lithium dilution (LiDCO) and pulse contour analysis (PulseCO) techniques in isoflurane-anaesthetized ponies before and during the administration of different inotropic/vasoactive drugs... This difference was influenced by inotropic/vasoactive drugs.

Maintenance treatment for patients with bipolar I disorder: results from a north american study of quetiapine in combination with lithium or divalproex (trial 127). [2009.04]
CONCLUSIONS: In patients stabilized on quetiapine plus lithium or divalproex, continued treatment was associated with a significant risk reduction in the time to recurrence of any mood event compared with placebo and lithium or divalproex.

Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease. [2009.03]
Preclinical and clinical studies gave evidence that lithium could be useful in the treatment of Alzheimer's disease (AD)... The results of the present investigation encourage performing studies with longer treatment phases to observe potential positive long-term effects of lithium in AD patients.

Bipolar I and II disorder residual symptoms: Oxcarbazepine and carbamazepine as add-on treatment to lithium in a double-blind, randomized trial. [2009.02.01]
Bipolar affective disorders often require adjunctive therapy to treat persistent symptoms. In order to evaluate bipolar symptoms inadequately responsive to lithium, we have compared the effects of two structurally related compounds carbamazepine (CBZ) and oxcarbazepine (OXC).However, further adequately placebo-controlled trials are needed to expand these findings.

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Clinical Trials Related to Lithium Citrate (Lithium)

Safety and Pharmacokinetics Study of Oral Lithium in Patients With Chronic Spinal Cord Injury [Active, not recruiting]
The current study is a phase I open-label clinical trial to examine plasma levels after oral lithium treatments in 20 subjects with chronic spinal cord injury. The subjects will receive standard doses of oral lithium used in treatment of manic depression. The goal of the trial is to show feasibility and safety of maintaining plasma levels of 0. 6 mmol/L to 1. 2 mmol/L for six weeks in subjects with chronic spinal cord injury.

Safety and Efficacy Study of Lithium in Bipolar Disorder [Active, not recruiting]
The purpose of this study is to determine whether Lithium is safe and effective in the treatment of Bipolar I Disorder subjects with symptoms of acute mania.

Long-Term Lithium Treatment for Aggressive Conduct Disorder [Completed]
This study will examine the long-term effects of lithium used to treat children and adolescents with aggressive conduct disorder (severe aggression).

Lithium Cannabis Withdrawal Study [Completed]
This trial will examine the efficacy of lithium in providing symptomatic relief from the withdrawal discomfort experienced by some dependent users of cannabis on cessation of regular use. Significant withdrawal may be a barrier to achieving abstinence in some clients and can be associated with marked disturbances in mood, sleep, hostility and aggression. Relief from such symptoms may be important in helping some clients achieve a period of abstinence and facilitate subsequent entry into a relapse prevention program.

Suicide Prevention by Lithium - the Lithium Intervention Study [Terminated]
The purpose of this study is to examine the proposed suicide preventive effects of lithium in a randomized controlled trial within a group of individuals with depressive disorders. The hypothesis being tested is that lithium treatment will significantly reduce the risk for another suicide attempt.

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Page last updated: 2009-10-28

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