Special attention must be given to recognizing
the signs and symptoms of overdosage, especially during the initial screening
and dose-titration phase of treatment, but also during reintroduction of
LIORESAL INTRATHECAL after a period of interruption in therapy.
Symptoms of LIORESAL INTRATHECAL Overdose: Drowsiness, lightheadedness, dizziness, somnolence, respiratory
depression, hypothermia, seizures, rostral progression of hypotonia and loss of consciousness progressing to coma of up to 72 hr. duration. In most cases reported,
coma was reversible without sequelae after drug was discontinued. Symptoms of
LIORESAL INTRATHECAL overdose were reported in a sensitive adult patient after
receiving a 25 mcg intrathecal bolus.
Treatment Suggestions for Overdose:
There is no specific antidote for treating overdoses of LIORESAL
INTRATHECAL (baclofen injection); however, the following steps should ordinarily
- Residual LIORESAL INTRATHECAL solution should be removed from the pump as
soon as possible.
- Patients with respiratory depression should be intubated if necessary, until
the drug is eliminated.
If lumbar puncture is not contraindicated, consideration should be given to withdrawing 30-40 mL of CSF to reduce CSF baclofen concentration.