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Lidocaine (Lidocaine Hydrochloride) - Summary



Lidocaine HCl 2% Jelly is a sterile, aqueous product that contains a local anesthetic agent and is administered topically.

Lidocaine HCl 2% Jelly is indicated for prevention and control of pain in procedures involving the male and female urethra, for topical treatment of painful urethritis, and as an anesthetic lubricant for endotracheal intubation (oral and nasal).

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Media Articles Related to Lidocaine

Breast cancer survivors who experience pain during intercourse may benefit from lidocaine
Source: Endocrinology News From Medical News Today [2015.07.28]
Dyspareunia, or painful sexual intercourse, is a common side effect of breast cancer treatment due to low estrogenScientists at Oregon Health & Science University report that breast cancer...

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Published Studies Related to Lidocaine

Intraoperative systemic lidocaine for pre-emptive analgesics in subtotal gastrectomy: a prospective, randomized, double-blind, placebo-controlled study. [2014]
lidocaine infusion in patients who underwent subtotal gastrectomy... CONCLUSION: Intravenous lidocaine infusion reduces pain during the postoperative

Efficacy of intraperitoneal and intravenous lidocaine on pain relief after laparoscopic cholecystectomy. [2014]
infusion for postoperative pain control after laparoscopic cholecystectomy (LC)... CONCLUSIONS: The IP administration of lidocaine and IV lidocaine infusion

Lidocaine/tetracaine peel in topical anesthesia prior to laser-assisted hair removal: Phase-II and Phase-III study results. [2014]
peel"), which air-dries and can be peeled off 30 min post-application... CONCLUSIONS: After a 30-min application, LT peel was effective and well-tolerated

Transversus abdominis plane block versus perioperative intravenous lidocaine versus patient-controlled intravenous morphine for postoperative pain control after laparoscopic colorectal surgery: study protocol for a prospective, randomized, double-blind controlled clinical trial. [2014]
BACKGROUND: Despite the laparoscopic approach becoming the standard in colorectal surgery, postoperative pain management for minimally invasive surgery is still mainly based on strategies that have been established for open surgical procedures... DISCUSSION: Recognizing the importance of a multimodal approach for perioperative pain management, we aim to investigate whether a transversus abdominis plane block delivers superior pain control in comparison to perioperative intravenous lidocaine and patient-controlled intravenous analgesia with morphine alone.

Intravenous lidocaine for the treatment of background or procedural burn pain. [2014]
CONCLUSIONS: As current clinical evidence is based on only one RCT as

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Clinical Trials Related to Lidocaine

Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia [Completed]
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be performed with a lower total dose of local anesthesia (and greater patient safety) when using 0. 5% lidocaine with 1: 200,000 epinephrine versus 1% lidocaine with 1: 100,000 epinephrine.

Preemptive Analgesia for Postlaminectomy [Completed]
To relieve post laminectomy pain, we have tried intraoperative perineural injection of lidocaine right after the exposure in expecting that this would be preemptive analgesia by blocking the nerve transmission so that postoperative pain starts later and lighter.

Lidocaine Lubricant in Pediatric Urethral Catheterization [Completed]
In Emergency Departments (ED) across the nation there is renewed interest in finding ways to alleviate the pain and discomfort associated with many of the procedures that children must undergo. In a policy by the American Academy of Pediatrics, a nationally recognized advocate for children, physicians are urged to advocate for child-specific research in pain management and the effective use of pain medication to ensure compassionate and competent management of pain. (AAP Statement, 2001) Pediatric urethral catheterizations are one such procedure in which children experience significant pain.(11) In present care, children over 2 months of age do not routinely receive intervention for urethral catheterization related anxiety and pain, and, anecdotal reports suggest that most require physical restraint to complete the procedure. Lidocaine is an anesthetic agent that provides relief from pain during many commonly performed ED procedures. Intraurethral Lidocaine has been shown to decrease pain associated with urethral catheter placement in cystograms, however, Lidocaine is not routinely used for urethral catheterizations in the CHOA ED.

This study aims to investigate the potential use of Lidocaine as an anesthetic agent during urethral catheterization of children. Recently, two specific studies were performed investigating the use of Lidocaine to decrease discomfort associated with urethral catheterization. Using the strengths of both previously published studies, our study will use Lidocaine both topically and instilled into the urethra. Investigators plan to perform a prospective three-arm double-blinded randomized clinical trial investigating the effectiveness of Lidocaine jelly as a analgesic when used as a lubricant for urinary catheterization. Investigators aim to demonstrate that Lidocaine used as a lubricant anesthetic for urethral catheterization will provide a safe, time-efficient, and relatively easy way to decrease pediatric pain in the emergency department setting.

Efficacy and Safety Study of Lidocaine Vaginal Gel for Recurrent Dysmenorrhea (Painful Periods) [Active, not recruiting]
The purpose of this study is to determine whether lidocaine vaginal gel is safe and effective for preventing or reducing the severity of dysmenorrhea (painful menstrual periods) compared to placebo (inactive gel).

Lidocaine Supplement for Minimal Invasive Parathyroid Surgery [Completed]
Primary Objective:

1. To determine if the application of lidocaine to the airway will obtund or abolish the laryngeal reflexes. This in turn will lead to a quiescent controlled surgical field.

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Reports of Suspected Lidocaine Side Effects

Anaphylactic Shock (31)Toxicity TO Various Agents (28)Blood Pressure Increased (25)Anaphylactic Reaction (21)Drug Ineffective (18)Loss of Consciousness (18)Burning Sensation (17)Weight Decreased (16)Blood Count Abnormal (15)Drug Interaction (15)more >>


Based on a total of 1 ratings/reviews, Lidocaine has an overall score of 10. The effectiveness score is 10 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.

Lidocaine review by 64 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   nerve and muscle pain
Dosage & duration:   5% (700 mg - 50 mg per gram adhesive) taken 1 for up to 12 hours@ 24 hours as needed for the period of Sporatically, as needed
Other conditions:   fibromyalgia
Other drugs taken:   naproxen sodium
Reported Results
Benefits:   Almost immediate (i.e. within 15 minutes) relieve of severe nerve and/or muscle pain in neck, shoulder &/or lower back. These patches work like a miracle for me, although others who have used them say they offered no relief for muscle or nerve or shingles pain. I have bone spurs in my neck which sometimes irritate the nerves in my neck and cause excrutiating pain ... also periodic sciatica and shoulder and upper & lower pack pain from an auto accident. Chiropractic and message helps, but these patches are used when those interventions fail to bring about sufficient relief ... especially for the nerve pain in my neck. I use them only as a last resort.
Side effects:   Relief of pain! No bad side effects.
Comments:   Although the packaging indicates that up to 3 Lidoderm patches can be used at one time for up to 12 hours in a 24 hour period, I have never used more then two patches, and then only rarely. I usually use one patch and cut it into several pieces to fit specific areas. I have used one patch, cut into 2 pieces on my neck for up to 24 hours several times (i.e. replaced the first patch with a second at the end of a 12 hour period) during severe pain episodes, without any harmful side effects.

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Page last updated: 2015-08-10

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