Lidocaine and Prilocaine (Lidocaine / Prilocaine Topical) - Summary

SUMMARY

LIDOCAINE and PRILOCAINE CREAM, 2.5%/2.5%

Lidocaine and prilocaine cream, 2.5%/2.5% is an emulsion in which the oil phase is a eutectic mixture of lidocaine and prilocaine in a ratio of 1:1 by weight. This eutectic mixture has a melting point below room temperature and therefore both local anesthetics exist as a liquid oil rather than as crystals. It is packaged in 30 gram tubes and 5 gram tubes for hospital use.

Lidocaine and prilocaine cream, 2.5%/2.5% (a eutectic mixture of lidocaine 2.5% and prilocaine 2.5%) is indicated as a topical anesthetic for use on:

•   - normal intact skin for local analgesia.
•  - genital mucous membranes for superficial minor surgery and as pretreatment for infiltration anesthesia. Lidocaine and prilocaine cream, 2.5%/2.5% is not recommended in any clinical situation in which penetration or migration beyond the tympanic membrane into the middle ear is possible because of the ototoxic effects observed in animal studies (see WARNINGS).

NEWS HIGHLIGHTS RELATED TO LIDOCAINE AND PRILOCAINE

Media Articles Related to Lidocaine and Prilocaine (Lidocaine / Prilocaine Topical)

Anesthesia Type Won't Influence Neck Artery Surgery Outcomes (HealthDay)
Source: Y! Health Cold & Flu News [2008.11.26]

Spinal Anesthesia Doesn't Cause Restless Leg Syndrome
Source: MedicineNet Allergy Specialty [2008.11.20]

Cooling The Brain Prevents Cell Death In Young Mice Exposed To Anesthesia
Source: Pain / Anesthetics News From Medical News Today [2008.11.18]

Award To HJF Nursing Specialist Recognizes Excellence In Caregiving
Source: Caregivers / Homecare News From Medical News Today [2008.11.09]

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Published Studies Related to Lidocaine and Prilocaine (Lidocaine / Prilocaine Topical)

Combination of topical EMLA with local injection of lidocaine: superior pain relief after ferguson hemorrhoidectomy. [2007.09]

Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. [2007.02]

Use of lidocaine-prilocaine patch for the mantoux test: Influence on pain and reading. [2006.12.11]

Lidocaine-prilocaine administration during transrectal ultrasound-guided prostatic biopsy: a randomized, single-blind, placebo-controlled trial. [2006.07]

Injection pain of prilocaine plain, mepivacaine plain, articaine with epinephrine, and lidocaine with epinephrine. [2006.05]

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Clinical Trials Related to Lidocaine and Prilocaine (Lidocaine / Prilocaine Topical)

Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia [Completed]

Preemptive Analgesia for Postlaminectomy [Completed]

Lidocaine Lubricant in Pediatric Urethral Catheterization [Completed]

Efficacy and Safety Study of Lidocaine Vaginal Gel for Recurrent Dysmenorrhea (Painful Periods) [Active, not recruiting]

Lidocaine Supplement for Minimal Invasive Parathyroid Surgery [Completed]

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