Lidocaine Hydrochloride and Epinephrine Injection, USP is a sterile, nonpyrogenic solution of lidocaine hydrochloride and epinephrine in water for injection for parenteral administration in various concentrations.
Lidocaine is a local anesthetic of the amide type.
Epinephrine, USP is a sympathomimetic (adrenergic) agent.
Lidocaine Hydrochloride and Epinephrine Injection, USP is indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection, by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these techniques as described in standard textbooks are observed.
Media Articles Related to Lidocaine and Epinephrine (Lidocaine / Epinephrine Epidural)
FDA Issues Class 1 Recall of Defective Anesthesia Products
Source: Medscape Anesthesiology Headlines [2013.11.26]
The US FDA has issued a Class 1 Recall of anesthesia products that provide respiratory support to patients due to a potential defect that may cause serious adverse health concerns, including death.
Anesthesia Technique May Affect Survival After Breast Cancer Surgery: Study
Source: MedicineNet Breast Specialty [2013.10.15]
Title: Anesthesia Technique May Affect Survival After Breast Cancer Surgery: Study
Category: OnHealth Staging
Created: 10/15/2013 4:36:00 PM
Last Editorial Review: 10/15/2013 4:35:43 PM
Anesthesia May Harm Children's Brains
Source: MedicineNet Ear Tubes Specialty [2012.08.20]
Title: Anesthesia May Harm Children's Brains
Category: Health News
Created: 8/20/2012 11:00:00 AM
Last Editorial Review: 8/20/2012 12:00:00 AM
The effect of propofol on the sciatic nerve
Source: Pain / Anesthetics News From Medical News Today [2013.11.05]
Propofol is a rapid, but short-acting, intravenous drug that is preferentially used for the induction and maintenance of anesthesia. Propofol can inhibit inflammation and suppress the secretion of the proinflammatory cytokines interleukin-1, interleukin-6 and tumor necrosis factor alpha from astrocytes, and enhance the synthesis and release of the anti-inflammatory cytokine interleukin-10.
Local anesthetic injected in neck reduces severe hot flashes
Source: Pain / Anesthetics News From Medical News Today [2013.11.04]
A shot in the neck of local anesthesia may reduce hot flashes by as much as 50 percent for at least six months, a recent Northwestern Medicine® study found.
Published Studies Related to Lidocaine and Epinephrine (Lidocaine / Epinephrine Epidural)
A comparison of the efficacy of 4% articaine with 1:100,000 epinephrine and 2%
lidocaine with 1:80,000 epinephrine in achieving pulpal anesthesia in maxillary
teeth with irreversible pulpitis. 
anesthesia in maxillary teeth with irreversible pulpitis... CONCLUSIONS: There was no significant difference in efficacy between 4% articaine
Influence of intranasal epinephrine and lidocaine spray on olfactory function tests in healthy human subjects. [2011.12]
Objective. Although topical decongestants and anesthetics are widely used in preparation for nasal endoscopy, no controlled trials have evaluated the effects of these agents on olfaction.Neither topical intranasal phenylephrine nor lidocaine use affected the results of the olfactory test, even when the agents were used in combination.
Effect of intravenous lidocaine associated with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine concentrations in fibromyalgia. [2011.05]
OBJECTIVE: The objective of this study was to evaluate the effect of intravenous lidocaine combined with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine levels... CONCLUSIONS: Combined administration of 240 mg intravenous lidocaine (once a week) and 25 mg amitriptyline for 4 weeks did not modify pain intensity or plasma serotonin, norepinephrine, or dopamine concentrations in fibromyalgia patients.
The effect of lidocaine, bupivacaine and ropivacaine in nasal packs on pain and hemorrhage after septoplasty. [2011.05]
We aimed to investigate the effects of local anesthetics soaked in Merocel nasal packs on hemorrhage and pain after septoplasty. The methodology includes a prospective double-blind study that was conducted in patients undergoing septoplasty because of nasal septal deviation...
Comparative evaluation of local infiltration of articaine, articaine plus ketorolac, and dexamethasone on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis. [2011.04]
INTRODUCTION: The inferior alveolar nerve block (IANB) has a poor success rate in patients with irreversible pulpitis. The purpose of this study was to evaluate the effect of ketorolac and dexamethasone infiltration along with standard IANB on the success rate... CONCLUSIONS: Articaine and ketorolac infiltration can increase the success rate of IANB in patients with irreversible pulpitis. None of the tested techniques gave 100% success rate. Copyright (c) 2011 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
Clinical Trials Related to Lidocaine and Epinephrine (Lidocaine / Epinephrine Epidural)
Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia [Completed]
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be
performed with a lower total dose of local anesthesia (and greater patient safety) when using
0. 5% lidocaine with 1: 200,000 epinephrine versus 1% lidocaine with 1: 100,000 epinephrine.
Preemptive Analgesia for Postlaminectomy [Completed]
To relieve post laminectomy pain, we have tried intraoperative perineural injection of
lidocaine right after the exposure in expecting that this would be preemptive analgesia by
blocking the nerve transmission so that postoperative pain starts later and lighter.
Lidocaine Lubricant in Pediatric Urethral Catheterization [Completed]
In Emergency Departments (ED) across the nation there is renewed interest in finding ways to
alleviate the pain and discomfort associated with many of the procedures that children must
undergo. In a policy by the American Academy of Pediatrics, a nationally recognized advocate
for children, physicians are urged to advocate for child-specific research in pain management
and the effective use of pain medication to ensure compassionate and competent management of
pain. (AAP Statement, 2001) Pediatric urethral catheterizations are one such procedure in
which children experience significant pain.(11) In present care, children over 2 months of
age do not routinely receive intervention for urethral catheterization related anxiety and
pain, and, anecdotal reports suggest that most require physical restraint to complete the
procedure. Lidocaine is an anesthetic agent that provides relief from pain during many
commonly performed ED procedures. Intraurethral Lidocaine has been shown to decrease pain
associated with urethral catheter placement in cystograms, however, Lidocaine is not
routinely used for urethral catheterizations in the CHOA ED.
This study aims to investigate the potential use of Lidocaine as an anesthetic agent during
urethral catheterization of children. Recently, two specific studies were performed
investigating the use of Lidocaine to decrease discomfort associated with urethral
catheterization. Using the strengths of both previously published studies, our study will use
Lidocaine both topically and instilled into the urethra. Investigators plan to perform a
prospective three-arm double-blinded randomized clinical trial investigating the
effectiveness of Lidocaine jelly as a analgesic when used as a lubricant for urinary
catheterization. Investigators aim to demonstrate that Lidocaine used as a lubricant
anesthetic for urethral catheterization will provide a safe, time-efficient, and relatively
easy way to decrease pediatric pain in the emergency department setting.
Efficacy and Safety Study of Lidocaine Vaginal Gel for Recurrent Dysmenorrhea (Painful Periods) [Active, not recruiting]
The purpose of this study is to determine whether lidocaine vaginal gel is safe and effective
for preventing or reducing the severity of dysmenorrhea (painful menstrual periods) compared
to placebo (inactive gel).
Lidocaine Supplement for Minimal Invasive Parathyroid Surgery [Completed]
1. To determine if the application of lidocaine to the airway will obtund or abolish the
laryngeal reflexes. This in turn will lead to a quiescent controlled surgical field.