SUMMARY
Lidocaine
HYDROCHLORIDE
and Epinephrine
Injection, USP
Lidocaine Hydrochloride and Epinephrine Injection, USP is a sterile, nonpyrogenic solution of lidocaine hydrochloride and epinephrine in water for injection for parenteral administration in various concentrations.
Lidocaine is a local anesthetic of the amide type.
Epinephrine, USP is a sympathomimetic (adrenergic) agent.
Lidocaine Hydrochloride and Epinephrine Injection, USP is indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection, by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these techniques as described in standard textbooks are observed.
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NEWS HIGHLIGHTSMedia Articles Related to Lidocaine and Epinephrine (Lidocaine / Epinephrine Epidural)
Abdominal Surgery Without General Anesthesia
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2009.11.04]
A recent review in Faculty of 1000 Medicine Reports, a publication in which clinicians highlight advances in medical practice, suggests regional pain relief could be used during abdominal surgery. In this review, Michael Schaefer recommends a new approach that can be performed without the need for general anaesthetics.
Anesthesia, Exertional Heat Deaths May Be Linked
Source: MedicineNet Hyperthermia Specialty [2009.10.26]
Title: Anesthesia, Exertional Heat Deaths May Be Linked
Category: Health News
Created: 10/23/2009 4:10:00 PM
Last Editorial Review: 10/26/2009
Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Source: MedicineNet Hernia Specialty [2009.03.25]
Title: Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Category: Health News
Created: 3/25/2009 2:00:00 AM
Last Editorial Review: 3/25/2009
Need For Emergency Airway Surgery For Hard-to-Intubate Patients Reduced
Source: Respiratory / Asthma News From Medical News Today [2009.11.18]
Be prepared, that old Boy Scout motto, is being applied with great success to operating room patients whose anatomy may make it difficult for physicians to help them breathe during surgery, Johns Hopkins researchers report in a new study. When patients undergo general anesthesia, they stop breathing on their own and anesthesiologists must quickly insert a tube into the airway as a first step in machine-assisted breathing.
New Technique For Injectable Facial Fillers Improves Comfort, Recovery
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2009.10.29]
Less pain during injections for wrinkle-fighting facial fillers. Less swelling afterward. Less time in the office waiting for anesthesia to take effect. These and other benefits of a new injection technique that UT Southwestern Medical Center plastic surgeons are helping pioneer are outlined in the October issue of Plastic and Reconstructive Surgery.
Published Studies Related to Lidocaine and Epinephrine (Lidocaine / Epinephrine Epidural)
Anesthetic efficacy of supplemental buccal and lingual infiltrations of articaine and lidocaine after an inferior alveolar nerve block in patients with irreversible pulpitis. [2009.07]
INTRODUCTION: The success rate of inferior alveolar nerve block (IANB) decreases in patients with irreversible pulpitis. It was hypothesized that supplemental infiltration of lidocaine and articaine may improve the success rates... CONCLUSIONS: Although supplemental buccal and lingual infiltrations of 4% articaine or 2% lidocaine increased the success rate of the inferior alveolar nerve block in patients with irreversible pulpitis, none of the techniques provided acceptable success rates.
Comparison of bupivacaine and lidocaine with epinephrine for digital nerve blocks. [2009.05]
OBJECTIVE: This study compared the efficacy in terms of pain of injection, time of onset and duration of action of digital blocks of bupivacaine 0.5% alone and lidocaine 1% with epinephrine (1:100,000)... CONCLUSION: Lidocaine (1%) with epinephrine (1:100 000) was significantly less painful and had a shorter duration of action than bupivacaine (0.5%), which had a similar onset of action for digital nerve block. Trial registration number: ISRCTN45121950.
A randomized, double-blind comparison of the total dose of 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine required for effective local anesthesia during Mohs micrographic surgery for skin cancers. [2009.03]
OBJECTIVE: We sought to compare total lidocaine dose and patient comfort when using 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine during Mohs micrographic surgery... CONCLUSION: The dose of 0.5% lidocaine with 1:200,000 epinephrine provides pain control equivalent to 1.0% lidocaine with 1:100,000 epinephrine at approximately half the total lidocaine dose.
Articaine buccal infiltration enhances the effectiveness of lidocaine inferior alveolar nerve block. [2009.03]
CONCLUSIONS: The IANB injection supplemented with articaine buccal infiltration was more successful than IANB alone for pulpal anaesthesia in mandibular teeth. Articaine buccal infiltration or dummy buccal infiltration was more comfortable than IANB.
A comparison of the anesthetic efficacy of articaine and lidocaine in patients with irreversible pulpitis. [2009.02]
The purpose of the present study was to compare the anesthetic efficacy of 4% articaine with 1:100,000 epinephrine with that of 2% lidocaine with 1:100,000 epinephrine during pulpectomy in patients with irreversible pulpitis in mandibular posterior teeth.Neither of the solutions, however, resulted in an effective pain control during irreversible pulpitis treatments.
Clinical Trials Related to Lidocaine and Epinephrine (Lidocaine / Epinephrine Epidural)
Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia [Completed]
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be
performed with a lower total dose of local anesthesia (and greater patient safety) when using
0. 5% lidocaine with 1: 200,000 epinephrine versus 1% lidocaine with 1: 100,000 epinephrine.
Preemptive Analgesia for Postlaminectomy [Completed]
To relieve post laminectomy pain, we have tried intraoperative perineural injection of
lidocaine right after the exposure in expecting that this would be preemptive analgesia by
blocking the nerve transmission so that postoperative pain starts later and lighter.
Lidocaine Lubricant in Pediatric Urethral Catheterization [Completed]
In Emergency Departments (ED) across the nation there is renewed interest in finding ways to
alleviate the pain and discomfort associated with many of the procedures that children must
undergo. In a policy by the American Academy of Pediatrics, a nationally recognized advocate
for children, physicians are urged to advocate for child-specific research in pain management
and the effective use of pain medication to ensure compassionate and competent management of
pain. (AAP Statement, 2001) Pediatric urethral catheterizations are one such procedure in
which children experience significant pain.(11) In present care, children over 2 months of
age do not routinely receive intervention for urethral catheterization related anxiety and
pain, and, anecdotal reports suggest that most require physical restraint to complete the
procedure. Lidocaine is an anesthetic agent that provides relief from pain during many
commonly performed ED procedures. Intraurethral Lidocaine has been shown to decrease pain
associated with urethral catheter placement in cystograms, however, Lidocaine is not
routinely used for urethral catheterizations in the CHOA ED.
This study aims to investigate the potential use of Lidocaine as an anesthetic agent during
urethral catheterization of children. Recently, two specific studies were performed
investigating the use of Lidocaine to decrease discomfort associated with urethral
catheterization. Using the strengths of both previously published studies, our study will use
Lidocaine both topically and instilled into the urethra. Investigators plan to perform a
prospective three-arm double-blinded randomized clinical trial investigating the
effectiveness of Lidocaine jelly as a analgesic when used as a lubricant for urinary
catheterization. Investigators aim to demonstrate that Lidocaine used as a lubricant
anesthetic for urethral catheterization will provide a safe, time-efficient, and relatively
easy way to decrease pediatric pain in the emergency department setting.
Efficacy and Safety Study of Lidocaine Vaginal Gel for Recurrent Dysmenorrhea (Painful Periods) [Active, not recruiting]
The purpose of this study is to determine whether lidocaine vaginal gel is safe and effective
for preventing or reducing the severity of dysmenorrhea (painful menstrual periods) compared
to placebo (inactive gel).
Lidocaine Supplement for Minimal Invasive Parathyroid Surgery [Completed]
Primary Objective:
1. To determine if the application of lidocaine to the airway will obtund or abolish the
laryngeal reflexes. This in turn will lead to a quiescent controlled surgical field.
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