Lidocaine Hydrochloride and Epinephrine Injection, USP is a sterile, nonpyrogenic solution of lidocaine hydrochloride and epinephrine in water for injection for parenteral administration in various concentrations.
Lidocaine Hydrochloride and Epinephrine Injection, USP is
indicated for production of local or regional anesthesia by infiltration
techniques such as percutaneous injection, by peripheral nerve block
techniques such as brachial plexus and intercostal and by central neural
techniques such as lumbar and caudal epidural blocks, when the accepted
procedures for these techniques as described in standard textbooks are
Media Articles Related to Lidocaine and Epinephrine (Lidocaine / Epinephrine Epidural)
Effects of Anaesthesia on Paediatric Lung Function
Source: Medscape Allergy & Clinical Immunology Headlines [2016.10.12]
Review pediatric respiratory physiology and the unique considerations for pediatric anesthesia in this comprehensive article.
British Journal of Anaesthesia
Published Studies Related to Lidocaine and Epinephrine (Lidocaine / Epinephrine Epidural)
Preemptive peritonsillar infiltration with lidocaine for relief of bipolar adult
post-tonsillectomy pain: a randomized, double-blinded clinical study. 
There are discordant results in the studies of the peritonsillar infiltration in
adults undergoing the tonsillectomy. The study is to compare the effect of the
preemptive peritonsillar infiltration with lidocaine in bipolar tonsillectomy in
Faster onset and more comfortable injection with alkalinized 2% lidocaine with
epinephrine 1:100,000. 
(IANBs)... CONCLUSIONS: Alkalinizing lidocaine with epinephrine toward physiologic pH
A comparison of the efficacy of 4% articaine with 1:100,000 epinephrine and 2%
lidocaine with 1:80,000 epinephrine in achieving pulpal anesthesia in maxillary
teeth with irreversible pulpitis. 
anesthesia in maxillary teeth with irreversible pulpitis... CONCLUSIONS: There was no significant difference in efficacy between 4% articaine
Influence of intranasal epinephrine and lidocaine spray on olfactory function tests in healthy human subjects. [2011.12]
Objective. Although topical decongestants and anesthetics are widely used in preparation for nasal endoscopy, no controlled trials have evaluated the effects of these agents on olfaction.Neither topical intranasal phenylephrine nor lidocaine use affected the results of the olfactory test, even when the agents were used in combination.
Effect of intravenous lidocaine associated with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine concentrations in fibromyalgia. [2011.05]
OBJECTIVE: The objective of this study was to evaluate the effect of intravenous lidocaine combined with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine levels... CONCLUSIONS: Combined administration of 240 mg intravenous lidocaine (once a week) and 25 mg amitriptyline for 4 weeks did not modify pain intensity or plasma serotonin, norepinephrine, or dopamine concentrations in fibromyalgia patients.
Clinical Trials Related to Lidocaine and Epinephrine (Lidocaine / Epinephrine Epidural)
Tumescent Lidocaine Maximum Safe mg/kg Dosage [Enrolling by invitation]
This pharmacokinetic clinical trial is a dose ranging study of lidocaine in tumescent local
anesthesia. The goal is to understand the absorption pharmacokinetic of tumescent lidocaine
and to determine an objective (statistical) estimate of the maximum safe mg/kg dosage of
lidocaine in tumescent local anesthesia without liposuction.
Lidocaine Infusion for Chronic Pain in Opioid Dependent Patients [Recruiting]
Prescription drug abuse represents a major healthcare problem, with treatment costs reaching
billions of dollars annually in the United States alone. Today opioids are commonly
prescribed for chronic non-cancer pain and are only partially effective for short-term pain
relief. Whereas opioids are initially part of the solution for pain, it eventually often
turns to be a problem in patient with chronic pain. Long-term treatment with opioids can be
complicated by development of tolerance, dependency, addiction, abnormal pain sensitivity,
hormonal changes, and immune modulation. Unfortunately, the chronic use of anti-inflammatory
drugs is associated with a marked increase in adverse effects.
The purpose of this study is to determine whether systemic administration of lidocaine
provides effective pain relief in opioid dependent chronic pain patients. Investigators
intend to demonstrate that lidocaine infusion can improve pain relief and physical function
in opioid dependent patients, thus improving compliance and patient satisfaction, which may
potentially help wean patients off narcotics. The long-term goal of this proposal is to
decrease opioid dependence in chronic pain patients by using lidocaine infusion.
Lidocaine: Effect of Lidocaine in Chronic Cough [Completed]
People cough in order to clear their airways. Most coughs are caused by viruses and settle
down by themselves, but some people develop persistent coughing which can be anywhere from 8
weeks to several years. This is called chronic cough. People with chronic cough find the
symptom distressing and it can have a major impact on their quality of life. Patients with
chronic cough often report a sensation at the back of their throat which makes them feel an
urge to cough. There is some evidence that Lidocaine (an anaesthetic used during medical
procedures) can suppress a person's cough when given to patients via a nebuliser (a machine
that turns liquid into a fine mist).
It is currently unknown whether using a local anaesthetic, such as Lidocaine, in the form of
a throat spray would successfully suppress a person's cough. A throat spray would be an
easier treatment option in chronic cough patients. Thus, the investigators research aims to
compare cough rates, severity and urge to cough scores between Lidocaine throat spray and
Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving [Recruiting]
We propose that the systemic administration of lidocaine following the induction of
cue-induced craving, relative to saline plus cue-induced craving or lidocaine without
cue-induced craving, will block the reconsolidation of cue memories. This will lead to a
reduction in cue-induced craving upon repeated testing as well as subsequent cocaine use and
Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft [Completed]
The aim of the present study is to compare the antiarrhythmic and myocardial protective
effect between lidocaine, dexmedetomidine, and their combined infusion in subjects
undergoing coronary artery bypass graft.