0.4% and 0.8% Lidocaine Hydrochloride and 5% Dextrose Injection, USP are sterile, nonpyrogenic solutions of lidocaine hydrochloride and 5% Dextrose Injection, USP for use in the management of ventricular arrhythmias. Each 100 mL contains lidocaine hydrochloride, anhydrous 400 mg (4 mg/mL) or 800 mg (8 mg/mL) and dextrose hydrous 5 g in water for injection. The osmolarity of the solutions is 282 and 311 mOsmol/liter (calc.) respectively. May contain hydrochloric acid and/or sodium hydroxide for pH adjustment. pH 4.0 (3.0 − 5.5). The solution contains no bacteriostatic, antimicrobial agent or added buffer (except for pH adjustment) and is intended only for use as a single-dose administration. When smaller doses are required, the unused portion should be discarded. Lidocaine administered intravenously is a cardiac antiarrhythmic agent.
Lidocaine Hydrochloride administered intravenously is specifically indicated in the acute management of (1) ventricular arrhythmias occurring during cardiac manipulation, such as cardiac surgery; and (2) life-threatening arrhythmias, particularly those which are ventricular in origin, such as occur during acute myocardial infarction.
Media Articles Related to Lidocaine and Dextrose (Lidocaine)
Adding corticosteroids to local anesthetic injections for spinal stenosis showed little benefit
Source: Pain / Anesthetics News From Medical News Today [2014.07.04]
Epidural injections with a glucocorticoid in combination with the local anesthetic lidocaine appear to be no better in reducing pain and physical limitations in patients with spinal stenosis, a...
Published Studies Related to Lidocaine and Dextrose (Lidocaine)
Cervical lidocaine for IUD insertional pain: a randomized controlled trial. 
intracervical 2% lidocaine gel for pain relief with IUD insertion... CONCLUSION: Topical or intracervical 2% lidocaine gel prior to IUD insertion does
Treatment for postoperative wound pain in gynecologic laparoscopic surgery:
topical lidocaine patches. 
CONCLUSIONS: Topical lidocaine patches at the laparoscopic port sites reduced
Lidocaine/tetracaine patch (Rapydan) for topical anaesthesia before arterial
access: a double-blind, randomized trial. 
non-inferior to subcutaneous local anaesthetic... CONCLUSIONS: Both the lidocaine/tetracaine patch and subcutaneous injection of
Intravenous lidocaine for the treatment of background or procedural burn pain. 
CONCLUSIONS: As current clinical evidence is based on only one single
Systemic lidocaine to improve postoperative quality of recovery after ambulatory
laparoscopic surgery. 
outpatient laparoscopic surgery... CONCLUSIONS: Systemic lidocaine improves postoperative quality of recovery in
Clinical Trials Related to Lidocaine and Dextrose (Lidocaine)
Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia [Completed]
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be
performed with a lower total dose of local anesthesia (and greater patient safety) when using
0. 5% lidocaine with 1: 200,000 epinephrine versus 1% lidocaine with 1: 100,000 epinephrine.
Preemptive Analgesia for Postlaminectomy [Completed]
To relieve post laminectomy pain, we have tried intraoperative perineural injection of
lidocaine right after the exposure in expecting that this would be preemptive analgesia by
blocking the nerve transmission so that postoperative pain starts later and lighter.
Lidocaine Lubricant in Pediatric Urethral Catheterization [Completed]
In Emergency Departments (ED) across the nation there is renewed interest in finding ways to
alleviate the pain and discomfort associated with many of the procedures that children must
undergo. In a policy by the American Academy of Pediatrics, a nationally recognized advocate
for children, physicians are urged to advocate for child-specific research in pain management
and the effective use of pain medication to ensure compassionate and competent management of
pain. (AAP Statement, 2001) Pediatric urethral catheterizations are one such procedure in
which children experience significant pain.(11) In present care, children over 2 months of
age do not routinely receive intervention for urethral catheterization related anxiety and
pain, and, anecdotal reports suggest that most require physical restraint to complete the
procedure. Lidocaine is an anesthetic agent that provides relief from pain during many
commonly performed ED procedures. Intraurethral Lidocaine has been shown to decrease pain
associated with urethral catheter placement in cystograms, however, Lidocaine is not
routinely used for urethral catheterizations in the CHOA ED.
This study aims to investigate the potential use of Lidocaine as an anesthetic agent during
urethral catheterization of children. Recently, two specific studies were performed
investigating the use of Lidocaine to decrease discomfort associated with urethral
catheterization. Using the strengths of both previously published studies, our study will use
Lidocaine both topically and instilled into the urethra. Investigators plan to perform a
prospective three-arm double-blinded randomized clinical trial investigating the
effectiveness of Lidocaine jelly as a analgesic when used as a lubricant for urinary
catheterization. Investigators aim to demonstrate that Lidocaine used as a lubricant
anesthetic for urethral catheterization will provide a safe, time-efficient, and relatively
easy way to decrease pediatric pain in the emergency department setting.
Efficacy and Safety Study of Lidocaine Vaginal Gel for Recurrent Dysmenorrhea (Painful Periods) [Active, not recruiting]
The purpose of this study is to determine whether lidocaine vaginal gel is safe and effective
for preventing or reducing the severity of dysmenorrhea (painful menstrual periods) compared
to placebo (inactive gel).
Lidocaine Supplement for Minimal Invasive Parathyroid Surgery [Completed]
1. To determine if the application of lidocaine to the airway will obtund or abolish the
laryngeal reflexes. This in turn will lead to a quiescent controlled surgical field.