SUMMARY
0.4% and 0.8% Lidocaine Hydrochloride and 5% Dextrose Injection, USP are sterile, nonpyrogenic solutions of lidocaine hydrochloride and 5% Dextrose Injection, USP for use in the management of ventricular arrhythmias. Each 100 mL contains lidocaine hydrochloride, anhydrous 400 mg (4 mg/mL) or 800 mg (8 mg/mL) and dextrose hydrous 5 g in water for injection. The osmolarity of the solutions is 282 and 311 mOsmol/liter (calc.) respectively. May contain hydrochloric acid and/or sodium hydroxide for pH adjustment. pH 4.0 (3.0 − 5.5). The solution contains no bacteriostatic, antimicrobial agent or added buffer (except for pH adjustment) and is intended only for use as a single-dose administration. When smaller doses are required, the unused portion should be discarded. Lidocaine administered intravenously is a cardiac antiarrhythmic agent.
Lidocaine Hydrochloride administered intravenously is specifically indicated in the acute management of (1) ventricular arrhythmias occurring during cardiac manipulation, such as cardiac surgery; and (2) life-threatening arrhythmias, particularly those which are ventricular in origin, such as occur during acute myocardial infarction.
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NEWS HIGHLIGHTS
Published Studies Related to Lidocaine and Dextrose (Lidocaine)
The analgesic effect of paracetamol when added to lidocaine for intravenous regional anesthesia. [2009.10]
BACKGROUND: In this study, we evaluated the effect of paracetamol on sensory and motor block onset time, tourniquet pain, and postoperative analgesia, when added to lidocaine in IV regional anesthesia (IVRA)... CONCLUSION: The addition of paracetamol during IVRA with lidocaine decreased tourniquet pain, increased anesthesia quality, and decreased postoperative analgesic consumption.
Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial. [2009.09.01]
BACKGROUND: The aim of this trial was to assess the relative efficacy of a sage/echinacea spray and a chlorhexidine/lidocaine spray in the treatment of acute sore throats... CONCLUSION: An echinacea/sage preparation is as efficacious and well tolerated as a chlorhexidine/lidocaine spray in the treatment of acute sore throats.
The impact of topical lidocaine on pain level assessment during and after vacuum-assisted closure dressing changes: a double-blind, prospective, randomized study. [2009.09]
BACKGROUND: Vacuum-assisted closure dressing changes are frequently painful. The authors hypothesized that administering topical lidocaine into the vacuum-assisted closure sponge would decrease pain during dressing changes... CONCLUSIONS: During the initial vacuum-assisted closure dressing change, 0.2% lidocaine administered through the suction tubing led to a reduction in pain reported by the patients in the authors' study. The duration of lidocaine administered in this fashion may be fairly short, because more patients in this group began to request small doses of opiates 30 minutes after the dressing change. Thus, lidocaine may improve patient comfort during vacuum-assisted closure therapy.
Lidocaine jelly and plain aqueous gel for urethral straight catheterization and the Q-tip test: a randomized controlled trial. [2009.09]
OBJECTIVE: To compare the pain perception between lidocaine and plain aqueous gel during assessment of postvoid residual volume and the Q-tip test... CONCLUSION: When compared with plain aqueous gel, 2% lidocaine jelly significantly reduces pain perception during evaluation of postvoid residual volume and the Q-tip test. LEVEL OF EVIDENCE: I.
Standard versus pH-adjusted and lidocaine supplemented radiocolloid for patients undergoing sentinel-lymph-node mapping and biopsy for early breast cancer (PASSION-P trial): a double-blind, randomised controlled trial. [2009.09]
BACKGROUND: Sentinel-lymph-node (SLN) mapping and biopsy maintains staging accuracy in early breast cancer and identifies patients for selective lymphadenectomy. SLN mapping requires injection of technetium-99m-sulfur colloid-an effective but sometimes painful method, for which better pain-management strategies are needed. In this randomised, double-blind trial, we compared degree of pain between standard radiocolloid injection and pH-adjusted and lidocaine-supplemented formulations for patients undergoing SLN mapping for breast cancer... INTERPRETATION: For centres that use radiocolloid injections for SLN mapping in patients with early breast cancer, the addition of 1% lidocaine to the radioisotope solution can improve patient comfort, without compromising SLN identification. FUNDING: US Military Cancer Institute, the Clinical Breast Care Project, and the Army Regional Anesthesia and Pain Management Initiative.
Clinical Trials Related to Lidocaine and Dextrose (Lidocaine)
Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia [Completed]
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be
performed with a lower total dose of local anesthesia (and greater patient safety) when using
0. 5% lidocaine with 1: 200,000 epinephrine versus 1% lidocaine with 1: 100,000 epinephrine.
Preemptive Analgesia for Postlaminectomy [Completed]
To relieve post laminectomy pain, we have tried intraoperative perineural injection of
lidocaine right after the exposure in expecting that this would be preemptive analgesia by
blocking the nerve transmission so that postoperative pain starts later and lighter.
Lidocaine Lubricant in Pediatric Urethral Catheterization [Completed]
In Emergency Departments (ED) across the nation there is renewed interest in finding ways to
alleviate the pain and discomfort associated with many of the procedures that children must
undergo. In a policy by the American Academy of Pediatrics, a nationally recognized advocate
for children, physicians are urged to advocate for child-specific research in pain management
and the effective use of pain medication to ensure compassionate and competent management of
pain. (AAP Statement, 2001) Pediatric urethral catheterizations are one such procedure in
which children experience significant pain.(11) In present care, children over 2 months of
age do not routinely receive intervention for urethral catheterization related anxiety and
pain, and, anecdotal reports suggest that most require physical restraint to complete the
procedure. Lidocaine is an anesthetic agent that provides relief from pain during many
commonly performed ED procedures. Intraurethral Lidocaine has been shown to decrease pain
associated with urethral catheter placement in cystograms, however, Lidocaine is not
routinely used for urethral catheterizations in the CHOA ED.
This study aims to investigate the potential use of Lidocaine as an anesthetic agent during
urethral catheterization of children. Recently, two specific studies were performed
investigating the use of Lidocaine to decrease discomfort associated with urethral
catheterization. Using the strengths of both previously published studies, our study will use
Lidocaine both topically and instilled into the urethra. Investigators plan to perform a
prospective three-arm double-blinded randomized clinical trial investigating the
effectiveness of Lidocaine jelly as a analgesic when used as a lubricant for urinary
catheterization. Investigators aim to demonstrate that Lidocaine used as a lubricant
anesthetic for urethral catheterization will provide a safe, time-efficient, and relatively
easy way to decrease pediatric pain in the emergency department setting.
Efficacy and Safety Study of Lidocaine Vaginal Gel for Recurrent Dysmenorrhea (Painful Periods) [Active, not recruiting]
The purpose of this study is to determine whether lidocaine vaginal gel is safe and effective
for preventing or reducing the severity of dysmenorrhea (painful menstrual periods) compared
to placebo (inactive gel).
Lidocaine Supplement for Minimal Invasive Parathyroid Surgery [Completed]
Primary Objective:
1. To determine if the application of lidocaine to the airway will obtund or abolish the
laryngeal reflexes. This in turn will lead to a quiescent controlled surgical field.
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Page last updated: 2009-10-20
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