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Lidex (Fluocinonide Topical) - Summary



Cream 0.05%

LIDEX® (fluocinonide) Gel 0.05% is intended for topical administration. The active component is the corticosteroid fluocinonide, which is the 21-acetate ester of fluocinolone acetonide.

LIDEX Gel is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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Published Studies Related to Lidex (Fluocinonide Topical)

Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis. [2011.02]
OBJECTIVE: To determine the effect a novel formulation of fluocinonide cream on skin barrier function in subjects with atopic dermatitis... CONCLUSION: The authors have shown that short-term treatment with a novel formulation of 0.1% fluocinonide led to significantly improved barrier function as measured by basal TEWL in subjects with active moderate to severe AD. These data suggest short-term treatment with AD with a super-potent corticosteroid improves skin barrier function.

An open-label adrenal suppression study of 0.1% fluocinonide cream in pediatric patients with atopic dermatitis. [2006.12]
OBJECTIVE: To assess the potential of a superhigh-potency 0.1% fluocinonide cream to suppress the hypothalamic-pituitary-adrenal (HPA) axis in pediatric patients with atopic dermatitis... CONCLUSIONS: Once-daily treatment with 0.1% fluocinonide cream for 2 weeks does not result in HPA axis suppression under the conditions of this study. Once-daily applications provided similar or better efficacy as twice-daily applications with a lower risk of HPA axis suppression. The frequency of HPA axis suppression is no greater in younger children than in older children. TRIAL REGISTRATION: isrctn.org Identifier: ISRCTN71227633.

Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis. [2011]
skin barrier function in subjects with atopic dermatitis... CONCLUSION: The authors have shown that short-term treatment with a novel

Improvement in treatment adherence with a 3-day course of fluocinonide cream 0.1% for atopic dermatitis. [2010.10]
Variations in adherence may cause variations in treatment outcomes with topical corticosteroid therapy for atopic dermatitis...

The efficacy of three class I topical synthetic corticosteroids, fluocinonide 0.1% cream, clobetasol 0.05% cream and halobetasol 0.05% cream: a Scholtz-Dumas bioassay comparison. [2009.08]
BACKGROUND: This study compared the efficacy of a novel, topical class I synthetic, 0.10% fluocinonide corticosteroid with two other class I corticosteroids and placebo for the treatment of plaque psoriasis... CONCLUSION: The three class I corticosteroid products were comparably effective, numerically and statistically, in clearing the psoriatic plaques. Upon completion of treatment, 60-80% of active-treated sites were clear or almost clear of psoriasis compared to zero with the placebo.

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Clinical Trials Related to Lidex (Fluocinonide Topical)

Fluocinonide Cream in Treating Symptoms of Vaginal Dryness and Painful Sexual Intercourse In Patients With Breast Cancer Undergoing Hormone Therapy [Recruiting]
This phase II trial studies how well giving fluocinonide cream works in treating symptoms of vaginal dryness and painful sexual intercourse in patients with breast cancer undergoing hormone therapy. Fluocinonide cream may prevent or lessen vaginal dryness and painful sexual intercourse in patients undergoing hormone therapy.

Efficacy of Fluocinonide Cream 0.1% (Vanos(R)) in Reducing Itch in Subjects With Atopic Dermatitis [Recruiting]
The purpose of this study is to assess the efficacy and tolerability of short-term treatment with fluocinonide cream 0. 1% (Vanos®) in the treatment of atopic dermatitis (AD). Our hypothesis is that subjects will have a reduction in Investigator's Global Assessment scores at Day 7 and Day 14 compared to Baseline. Secondary objectives include the use of actigraphy monitoring to determine the ability of Vanos® cream to reduce itch, and thus nocturnal scratching, in AD. Our hypothesis is that subjects will have a reduction in nocturnal scratching activity, as measured by actigraphy movement count per hour, at Day 7 and Day 14 compared to Baseline. Other secondary outcome measures include Eczema Area and Severity Index (EASI) score, body surface area involvement, Visual Analog Scale for itch, and Subject Global Assessment. The investigators hypothesize that each of these measures will be improved at Day 7 and Day 14 compared to Baseline. Medication adherence will be determined using objective adherence monitors. The investigators also hypothesize that subjects will have improved adherence to a topical medication for AD, compared to published sources, if they are only required to use the medication for a short and defined duration.

Effectiveness of Imiquimod 3.75% Topical Cream Compared to Vanos Cream 0.1% in Subjects With Early Stage Cutaneous T-cell Lymphoma [Not yet recruiting]
This study is being conducted by the Department of Dermatology at the University of Rochester. The purpose of this study is to determine safety, effectiveness, and tolerability of two topical therapies, imiquimod and fluocinonide, for patients with early stage Cutaneous T-cell Lymphoma (CTCL).

VANOS Cream and Skin Barrier Function [Recruiting]
The purpose of this study is to determine the effect of short-term therapy using "VANOS Cream," a super-potent topical steroid cream on skin barrier function in patients with atopic dermatitis. This cream is already approved for this indication, but the investigators will further examine its effects on the skin barrier. This cream is a novel formulation of fluocinonide designed to enhance compliance with a cream base, but have the skin barrier repair properties of an ointment.

Using an Internet Study to Improve Adherence for Psoriasis Patients [Recruiting]
To evaluate whether participation in an Internet-based intervention helps improve short-term and long-term psoriasis treatment outcomes, in particular, adherence.

more trials >>


Based on a total of 1 ratings/reviews, Lidex has an overall score of 7. The effectiveness score is 8 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.

Lidex review by 32 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   dermatitis
Dosage & duration:   apply to affected area(s) twice a day (dosage frequency: once a day(or more), as needed) for the period of approx. 1 year, on and off
Other conditions:   tinnea versicolor on arms and legs
Other drugs taken:   ketocozonale (oral & topical)
Reported Results
Benefits:   The ointment kept the symptoms of the dermatitis(i.e. itching, scaling and cracking) to a minimum. As long as the treatment was part of my daily regiment it was very effective.
Side effects:   When I fell behind on the regular application of the ointment, the dermatitis would flare up within 2-3 days. Unfortunately, the ointment fails to "cure" the problem and only treats the symptoms.
Comments:   The application is very simple. Just apply the ointment to the affected area(bottoms of my feet) twice a day. The Dr. recommended I exfoliate the area regularly to remove any build-up of skin. Following that recommendation I would use a pumice stone 4-5 times a week prior to applying the treatment.

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Page last updated: 2013-02-10

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