DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Lexxel (Enalapril Maleate / Felodipine) - Summary

 

-- advertisement --

USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, LEXXEL should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.

 

LEXXEL SUMMARY

LEXXEL®
(enalapril maleate-felodipine ER)
TABLETS

LEXXEL (enalapril maleate-felodipine ER) is a combination product, consisting of an outer layer of enalapril maleate surrounding a core tablet of an extended-release felodipine formulation. Enalapril maleate is the maleate salt of enalapril, the ethyl ester of a long-acting angiotensin converting enzyme inhibitor, enalaprilat.

LEXXEL is indicated for the treatment of hypertension.

This fixed combination drug is not indicated for the initial therapy of hypertension. (See DOSAGE AND ADMINISTRATION.)

In using LEXXEL, consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that enalapril (a component of LEXXEL) does not have a similar risk. (See WARNINGS, Neutropenia/Agranulocytosis.)

In considering use of LEXXEL, it should be noted that black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to non-blacks. (See WARNINGS, Angioedema.)

LEXXEL NEWS HIGHLIGHTS

Media Articles Related to Lexxel (Enalapril / Felodipine)

Possible Association Between High Levels Of Uric Acid And Hypertension
Source: Health News from Medical News Today [2008.08.28]

Allopurinol May Lower Blood Pressure In Teens With Hypertension
Source: Hypertension News From Medical News Today [2008.08.28]

Drug Designed To Lower Uric Acid Levels May Be Useful For Hypertension
Source: Blood / Hematology News From Medical News Today [2008.08.27]

Reducing Uric Acid Shows Promise for Hypertension in Children
Source: MedPage Today Cardiovascular [2008.08.26]

GP-Led Hypertension Health Promotion Campaign Delivers Response Rates Of 76%
Source: Hypertension News From Medical News Today [2008.08.21]

more>>

Page last updated: 2008-08-28

-- advertisement -- The American Red Cross

We comply with
HONcode standard.
Verify here.
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2008