USE IN PREGNANCY
When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, LEXXEL should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.
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LEXXEL SUMMARY
LEXXEL®
(enalapril maleate-felodipine ER)
TABLETS
LEXXEL (enalapril maleate-felodipine ER) is a combination product, consisting of an outer layer of enalapril maleate surrounding a core tablet of an extended-release felodipine formulation. Enalapril maleate is the maleate salt of enalapril, the ethyl ester of a long-acting angiotensin converting enzyme inhibitor, enalaprilat.
LEXXEL is indicated for the treatment of hypertension.
This fixed combination drug is not indicated for the initial therapy of hypertension. (See DOSAGE AND ADMINISTRATION.)
In using LEXXEL, consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that enalapril (a component of LEXXEL) does not have a similar risk. (See WARNINGS, Neutropenia/Agranulocytosis.)
In considering use of LEXXEL, it should be noted that black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to non-blacks. (See WARNINGS, Angioedema.)
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NEWS HIGHLIGHTSMedia Articles Related to Lexxel (Enalapril / Felodipine)
Marijuana Use May Raise Risk of Dying From Hypertension
Source: Medscape Anesthesiology Headlines [2017.08.17]
NHANES data suggest marijuana users have a threefold risk of dying from hypertension, and the risk increases with each additional year of use.
Medscape Medical News
Pulmonary Hypertension (Symptoms, Treatment Medications, Life Expectancy)
Source: MedicineNet Cirrhosis Specialty [2017.07.26]
Title: Pulmonary Hypertension (Symptoms, Treatment Medications, Life Expectancy)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 7/26/2017 12:00:00 AM
Hypertension before the age of 55 increases risk of cardiovascular death
Source: Hypertension News From Medical News Today [2017.05.19]
When someone gets diagnosed with hypertension, either early (before the age of 55) or later in life, can have important health ramifications.
Simple blood tests lead to improved hypertension treatment in African countries
Source: Hypertension News From Medical News Today [2017.05.04]
Using two simple blood tests, Western University researchers were able to drastically improve treatment for resistant hypertension across three sites in Nigeria, Kenya and South Africa.
Diabetes and hypertension: What is the relationship?
Source: Hypertension News From Medical News Today [2017.04.29]
Hypertension, or high blood pressure, is linked to diabetes, and each condition can make the other worse. How can people reduce the associated risks?
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Page last updated: 2017-08-17
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