USE IN PREGNANCY
When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, LEXXEL should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.
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LEXXEL SUMMARY
LEXXEL®
(enalapril maleate-felodipine ER)
TABLETS
LEXXEL (enalapril maleate-felodipine ER) is a combination product, consisting of an outer layer of enalapril maleate surrounding a core tablet of an extended-release felodipine formulation. Enalapril maleate is the maleate salt of enalapril, the ethyl ester of a long-acting angiotensin converting enzyme inhibitor, enalaprilat.
LEXXEL is indicated for the treatment of hypertension.
This fixed combination drug is not indicated for the initial therapy of hypertension. (See DOSAGE AND ADMINISTRATION.)
In using LEXXEL, consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that enalapril (a component of LEXXEL) does not have a similar risk. (See WARNINGS, Neutropenia/Agranulocytosis.)
In considering use of LEXXEL, it should be noted that black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to non-blacks. (See WARNINGS, Angioedema.)
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NEWS HIGHLIGHTSMedia Articles Related to Lexxel (Enalapril / Felodipine)
Small study makes important discovery about idiopathic pulmonary arterial hypertension
Source: Cardiovascular / Cardiology News From Medical News Today [2015.01.19]
A small study being published in Annals of Internal Medicine may reveal an important discovery about idiopathic pulmonary arterial hypertension (IPAH), a rare and deadly disease.
Kidney donation by older people with hypertension may be safe with proper monitoring
Source: Hypertension News From Medical News Today [2014.12.31]
With proper monitoring, kidney donation may be safe for individuals with high blood pressure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology...
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Source: Hypertension News From Medical News Today [2014.12.18]
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Source: Fertility News From Medical News Today [2014.12.10]
A study of more than 9,000 men with fertility problems has revealed a correlation between the number of different defects in a man's semen and the likelihood that the man has other health problems.
Picture of Hypertension
Source: MedicineNet Pregnancy Induced Hypertension Specialty [2014.12.09]
Title: Picture of Hypertension
Category: Images
Created: 2/3/2011 1:47:00 PM
Last Editorial Review: 12/9/2014 12:00:00 AM
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Page last updated: 2015-01-19
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