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Lexxel (Enalapril Maleate / Felodipine) - Summary

 
 



USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, LEXXEL should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.

 

LEXXEL SUMMARY

LEXXEL®
(enalapril maleate-felodipine ER)
TABLETS

LEXXEL (enalapril maleate-felodipine ER) is a combination product, consisting of an outer layer of enalapril maleate surrounding a core tablet of an extended-release felodipine formulation. Enalapril maleate is the maleate salt of enalapril, the ethyl ester of a long-acting angiotensin converting enzyme inhibitor, enalaprilat.

LEXXEL is indicated for the treatment of hypertension.

This fixed combination drug is not indicated for the initial therapy of hypertension. (See DOSAGE AND ADMINISTRATION.)

In using LEXXEL, consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that enalapril (a component of LEXXEL) does not have a similar risk. (See WARNINGS, Neutropenia/Agranulocytosis.)

In considering use of LEXXEL, it should be noted that black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to non-blacks. (See WARNINGS, Angioedema.)


See all Lexxel indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Lexxel (Enalapril / Felodipine)

Left Ventricular Heart Failure and Pulmonary Hypertension
Source: Medscape Critical Care Headlines [2016.06.23]
This review examines the complex pathophysiology of pulmonary hypertension as it relates to left ventricular heart failure. What are the diagnostic pitfalls, and current therapeutic options?
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Blood test shows promise in gauging severity of pulmonary arterial hypertension
Source: Respiratory / Asthma News From Medical News Today [2016.06.22]
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Source: Cardiovascular / Cardiology News From Medical News Today [2016.06.21]
The music of Mozart and Strauss is able to lower blood lipid concentrations and the heart rate.

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Source: Cardiovascular / Cardiology News From Medical News Today [2016.06.18]
The negative health implications of exposure to aircraft sound are slowly being uncovered. Hypertension and organ damage are the latest to join the list.

Hepatitis C: Once the viral infection has healed, high-risk portal vein hypertension also diminishes
Source: Hypertension News From Medical News Today [2016.06.16]
This inflammatory viral infection of the liver causes inflexible scar tissue to form. This in turn impedes blood flow through the organ, with resulting hypertension in the portal vein.

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Page last updated: 2016-06-23

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