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Lexxel (Enalapril Maleate / Felodipine) - Summary

 
 



USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, LEXXEL should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.

 

LEXXEL SUMMARY

LEXXEL®
(enalapril maleate-felodipine ER)
TABLETS

LEXXEL (enalapril maleate-felodipine ER) is a combination product, consisting of an outer layer of enalapril maleate surrounding a core tablet of an extended-release felodipine formulation. Enalapril maleate is the maleate salt of enalapril, the ethyl ester of a long-acting angiotensin converting enzyme inhibitor, enalaprilat.

LEXXEL is indicated for the treatment of hypertension.

This fixed combination drug is not indicated for the initial therapy of hypertension. (See DOSAGE AND ADMINISTRATION.)

In using LEXXEL, consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that enalapril (a component of LEXXEL) does not have a similar risk. (See WARNINGS, Neutropenia/Agranulocytosis.)

In considering use of LEXXEL, it should be noted that black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to non-blacks. (See WARNINGS, Angioedema.)


See all Lexxel indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Lexxel (Enalapril / Felodipine)

1st Gulf Hypertension Conference, 26-29 January 2015, Dubai
Source: Conferences News From Medical News Today [2014.11.13]
Research has highlighted that more than 37% of people in the UAE and 26% in KSA are suffering from hypertension, known as 'the silent killer' due to its rare display of symptoms.

Hypertension medication linked with reduced ALS risk
Source: Hypertension News From Medical News Today [2014.11.11]
A new study has found that the use of angiotensin-converting enzyme inhibitors is associated with a reduced risk of developing the neurological disorder ALS.

Could an explosive compound reduce hereditary hypertension risk for women?
Source: Hypertension News From Medical News Today [2014.11.11]
Researchers from Germany found that an explosive compound called PETN lowered the systolic blood pressure of female rats born to parents with hypertension.

Lack of transcription factor FoxO1 triggers pulmonary hypertension
Source: Hypertension News From Medical News Today [2014.10.30]
Pulmonary hypertension is characterised by uncontrolled division of cells in the blood vessel walls. As a result, the vessel walls become increasingly thick.

Research suggests team-based care is most effective way to control hypertension
Source: Hypertension News From Medical News Today [2014.10.24]
Patients diagnosed with high blood pressure are given better control of their condition from a physician-pharmacist collaborative intervention than physician management alone, according to new...

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Page last updated: 2014-11-13

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