NEWS HIGHLIGHTS
Published Studies Related to Lexiscan (Regadenoson)
Differences in heart rate response to adenosine and regadenoson in patients with and without diabetes mellitus. [2009.04]
BACKGROUND: Adenosine and regadenoson increase heart rate (HR) when used as stress agents to produce coronary hyperemia due to direct sympathetic stimulation. We hypothesized that the HR response will be lower in patients with than in those without diabetes mellitus (DM)... CONCLUSIONS: The HR response to adenosine and regadenoson in patients with DM is blunted. If additional studies confer an agreement between traditional tests for determination of autonomic neuropathy and this measure, then examination of HR response to these agents during myocardial perfusion imaging might add prognostic power.
The RegEx trial: a randomized, double-blind, placebo- and active-controlled pilot study combining regadenoson, a selective A(2A) adenosine agonist, with low-level exercise, in patients undergoing myocardial perfusion imaging. [2009.01]
BACKGROUND: Although vasodilator stress myocardial perfusion imaging (MPI) is increasingly performed with exercise, adenosine A(2A) receptor agonists have not been studied with exercise. OBJECTIVES: To determine the safety of administering regadenoson during exercise and, secondarily, to evaluate image quality, patient acceptance, and detection of perfusion defects... CONCLUSIONS: Combining regadenoson with low-level exercise is feasible, well tolerated, and associated with fewer side effects compared to AdenoSup.
Safety of regadenoson, an adenosine A2A receptor agonist for myocardial perfusion imaging, in mild asthma and moderate asthma patients: a randomized, double-blind, placebo-controlled trial. [2008.05]
CONCLUSIONS: In this pilot safety study of 48 patients with mild or moderate asthma who had bronchial reactivity to adenosine monophosphate, regadenoson was safe and well tolerated.
Safety of regadenoson, a selective adenosine A2A agonist, in patients with chronic obstructive pulmonary disease: A randomized, double-blind, placebo-controlled trial (RegCOPD trial). [2008.05]
CONCLUSIONS: This pilot study showed the overall safety of regadenoson in 49 compromised outpatients with clinically stable moderate and severe chronic obstructive pulmonary disease.
Effects of age, gender, obesity, and diabetes on the efficacy and safety of the selective A2A agonist regadenoson versus adenosine in myocardial perfusion imaging integrated ADVANCE-MPI trial results. [2008.05]
OBJECTIVES: To compare the effects of age, gender, body mass index, and diabetes on the safety and efficacy of regadenoson stress myocardial perfusion imaging, and to assess the noninferiority of regadenoson to adenosine for the detection of reversible myocardial perfusion defects. BACKGROUND: Previous reports have shown that a fixed unit bolus of regadenoson is safe and noninferior to adenosine for the detection of reversible perfusion defects by radionuclide imaging... CONCLUSIONS: Regadenoson can be safely administered as a fixed unit bolus and is as efficacious as adenosine in detecting ischemia regardless of age, gender, body mass index, and diabetes. Regadenoson is better tolerated overall and across various subgroups.
Clinical Trials Related to Lexiscan (Regadenoson)
Myocardial Perfusion Magnetic Resonance Imaging Using Regadenoson [Not yet recruiting]
This is a pilot study to determine whether the drug regadenoson can be used during magnetic
resonance imaging to assess regions of poor blood flow to the heart.
The hypothesis of this study is that a single injection of regadenoson could be used instead
of a standard adenosine infusion to produce coronary vasodilatation and demonstrate
myocardial ischemia during first-pass perfusion cardiac MRI.
A Study of the Safety and Tolerance of Regadenoson in Subjects With Asthma or Chronic Obstructive Pulmonary Disease [Recruiting]
This study is intended to determine the safety and tolerance of regadenoson in subjects with
asthma or chronic obstructive pulmonary disease.
Comparison of Dobutamine and Regadenoson Stress Cardiac MR [Not yet recruiting]
The goal of this research is to determine the utility of Regadenoson (Lexiscan)for use as an
imaging agent with cardiac MR. If found useful, it will help us establish a protocol for
regadenoson stress MR perfusion (Regadenoson stress test with cardiac MR). We will compare
regadenoson with dobutamine so each participant will undergo two studies. A cardiac MR
stress test with regadenoson and with dobutamine. Our participants will include patients
with history of COPD and Asthma, so it will also help us determine feasibility of
Regadenoson in these patient's subgroups.
A Study of the Safety and Tolerance of Regadenoson in Subjects With Renal Impairment [Recruiting]
This study is intended to assess the safety and tolerance of regadenoson in subjects with
renal impairment.
Stress Echocardiography Study With Regadenoson [Recruiting]
Regadenoson is approved in the US under the brand name Lexiscan for myocardial perfusion
imaging. This study will test whether regadenoson is an appropriate stress agent for stress
echocardiography.
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