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Levophed (Norepinephrine Bitartrate) - Summary

 

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BOX WARNING

IMPORTANT ― Antidote for Extravasation Ischemia: To prevent sloughing and necrosis in areas in which extravasation has taken place, the area should be infiltrated as soon as possible with 10 mL to 15 mL of saline solution containing from 5 mg to 10 mg of Regitine® (brand of phentolamine), an adrenergic blocking agent. A syringe with a fine hypodermic needle should be used, with the solution being infiltrated liberally throughout the area, which is easily identified by its cold, hard, and pallid appearance. Sympathetic blockade with phentolamine causes immediate and conspicuous local hyperemic changes if the area is infiltrated within 12 hours. Therefore, phentolamine should be given as soon as possible after the extravasation is noted.

 

LEVOPHED SUMMARY

LEVOPHED®
Norepinephrine Bitartrate
Injection, USP

Norepinephrine (sometimes referred to as l-arterenol/Levarterenol or l-norepinephrine) is a sympathomimetic amine which differs from epinephrine by the absence of a methyl group on the nitrogen atom.

Levophed (Norepinephrine) is indicated for the following:

For blood pressure control in certain acute hypotensive states (e.g., pheochromocytomectomy, sympathectomy, poliomyelitis, spinal anesthesia, myocardial infarction, septicemia, blood transfusion, and drug reactions).

As an adjunct in the treatment of cardiac arrest and profound hypotension.

LEVOPHED NEWS HIGHLIGHTS

Media Articles Related to Levophed (Norepinephrine)

Low Blood Pressure (Hypotension) Photo Slideshow
Source: MedicineNet Abdominal Aortic Aneurysm Specialty [2008.07.30]

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Published Studies Related to Levophed (Norepinephrine)

Vasopressin versus norepinephrine infusion in patients with septic shock. [2008.02.28]

Glibenclamide dose response in patients with septic shock: effects on norepinephrine requirements, cardiopulmonary performance, and global oxygen transport. [2007.11]

Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial. [2007.08.25]

Acarbose, an alpha-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failure. [2007.07]

Norepinephrine transporter gene variation modulates acute response to D-amphetamine. [2007.06.01]

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Clinical Trials Related to Levophed (Norepinephrine)

Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock [Completed]

Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock [Recruiting]

Dopexamine and Norepinephrine Compared With Epinephrine Alone in Septic Shock [Completed]

Phenylephrine in Septic Shock [Recruiting]

Noradrenalin vs Terlipressin in Hepatorenal Syndrome [Completed]

more>>

Page last updated: 2008-07-30

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