Levobunolol (Levobunolol Hydrochloride Ophthalmic) - Summary

LEVOBUNOLOL SUMMARY

Levobunolol
Hydrochloride
Ophthalmic Solution, USP
Sterile

Levobunolol Hydrochloride Ophthalmic Solution is a sterile, noncardioselective beta-adrenoceptor blocking agent for ophthalmic use. The solution is colorless to slightly light yellow in appearance with an osmoloity range of 250-360 mOsm/kg. The shelf life pH range is 5.5 to 7.5.

Levobunolol (levobunolol OPHTHALMIC) is indicated for the following:

Levobunolol Hydrochloride Ophthalmic Solution has been shown to be effective in lowering intraocular pressure and may be used in patients with chronic open-angle glaucoma or ocular hypertension.

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NEWS HIGHLIGHTS

Published Studies Related to Levobunolol (Levobunolol Ophthalmic)

Poly (epsilon-caprolactone) microparticles containing Levobunolol HCl prepared by a multiple emulsion (W/O/W) solvent evaporation technique: effects of some formulation parameters on microparticle characteristics. [2009.02]
The aim of this study was to prepare poly (epsilon-caprolactone) (PCL) microparticles of Levobunolol HC1 (L-HC1) for use as an anti-glaucomatous drug to the eye. The double emulsion (W/O/W) solvent evaporation technique was used for encapsulating L-HC1 as a hydrophilic drug... Drug release was slower when the microparticle was incorporated into the thermally reversible gel (Pluronic F127) in comparison to drug release from the free drug incorporated into the gel and drug release from the free microparticle.

An in vivo confocal microscopy and impression cytology analysis of preserved and unpreserved levobunolol-induced conjunctival changes. [2008.05]
PURPOSE... All the IVCM and impression cytology parameters correlated well with the conjunctival modifications induced by the topical therapy, suggesting the less toxicity of unpreserved drugs.

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