Levo-Dromoran (Levorphanol Tartrate) - Summary

LEVO-DROMORAN SUMMARY

LEVO-DROMORAN™ C-II
(levorphanol tartrate)
AMPULS, VIALS, TABLETS
Potent Synthetic Opioid
For Parenteral Or Oral Administration

Levo-Dromoran (levorphanol tartrate) is a potent opioid analgesic with empirical formula C₁₇H₂₃NO•C₄H₆O₆•2H₂O and molecular weight 443.

Levo-Dromoran is indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate.

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NEWS HIGHLIGHTS

Published Studies Related to Levo-Dromoran (Levorphanol)

Can levorphanol be used like methadone for intractable refractory pain? [2007.04]
BACKGROUND: Levorphanol has been reported to provide analgesia at doses that suggest it does not act like other pure agonist opioids... Could it be that levorphanol may have a role like methadone for pain that is poorly controlled with other pure agonist opioids? We summarize what is known about levorphanol and provide a table for converting other opioids to levorphanol that was used for this case series.

Levorphanol: the forgotten opioid. [2007.03]
CONCLUSION: The long half-life of the drug increases the potential for drug accumulation. Levorphanol has clinical efficacy in neuropathic pain.

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Clinical Trials Related to Levo-Dromoran (Levorphanol)

Evolution of Analgesic Tolerance With Opioids [Active, not recruiting]
The purpose of this study is to determine the extent to which analgesic tolerance develops in chronic pain patients who are either started on opioids or who receive an increase in pre-study opioid dose level and then observed during long-term (20 weeks) stable opioid therapy. In addition to clinical measures of relief of ongoing chronic pain, estimation of tolerance development will be supplemented by periodic assessment of the anti-nociceptive effects of opioids using the brief thermal sensitization model.

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