LEVETIRACETAM SUMMARY
Levetiracetam is an antiepileptic drug available as a clear, colorless, grape-flavored liquid (100 mg/mL) for oral administration.
Levetiracetam is indicated as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy.
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NEWS HIGHLIGHTSMedia Articles Related to Levetiracetam
Link Between Epilepsy And Autism Found
Source: Autism News From Medical News Today [2013.05.16]
Adults with epilepsy are more likely to have a greater number of characteristics of autism and Asperger syndrome, according to new research by the University of Bath, England. The finding was discovered by Dr. SallyAnn Wakeford, a PhD student from the University's Department of Psychology, and revealed a previously unknown link between epileptic seizures and the signs of autism in adults...
Brain Cells Cure Epilepsy In Mouse Model
Source: Epilepsy News From Medical News Today [2013.05.08]
UCSF scientists controlled seizures in epileptic mice with a one-time transplantation of medial ganglionic eminence (MGE) cells, which inhibit signaling in overactive nerve circuits, into the hippocampus, a brain region associated with seizures, as well as with learning and memory...
Model Cell System Offers Insights Into Epilepsy, Schizophrenia, Other Neuropsych Disorders
Source: Autism News From Medical News Today [2013.05.06]
Medical researchers have manipulated human stem cells into producing types of brain cells known to play important roles in neurodevelopmental disorders such as epilepsy, schizophrenia and autism...
Implanted Device Predicts Epilepsy Seizures In Humans
Source: Epilepsy News From Medical News Today [2013.05.02]
For the first time, a small device implanted in the brain has accurately predicted the onset of seizures in some adults who have epilepsy that doesn't respond to drugs, according to a small proof-of-concept study published Online First in The Lancet Neurology...
Implanted Device May Predict Epilepsy Seizures, Study Suggests
Source: MedicineNet Seizure Specialty [2013.05.02]
Title: Implanted Device May Predict Epilepsy Seizures, Study Suggests
Category: Health News
Created: 5/2/2013 10:35:00 AM
Last Editorial Review: 5/2/2013 12:00:00 AM
Published Studies Related to Levetiracetam
Levetiracetam in the treatment of alcohol dependence: toward the end of the
story? [2012]
that levetiracetam may be efficient in alcohol-related disorder... CONCLUSIONS: By conducting a state-of-the-art randomized-controlled clinical
A double-blind, placebo-controlled trial assessing the efficacy of levetiracetam
extended-release in very heavy drinking alcohol-dependent patients. [2012]
population of very heavy drinkers... CONCLUSIONS: This multisite clinical trial showed no efficacy for levetiracetam
Double-masked, placebo-controlled study of intravenous levetiracetam for the
treatment of status epilepticus and acute repetitive seizures in dogs. [2012]
BACKGROUND: Status epilepticus (SE) and acute repetitive seizures (ARS) are
common canine neurologic emergencies...
A randomized, double-blind, placebo-controlled trial of levetiracetam for dyskinesia in Parkinson's disease. [2011.07]
BACKGROUND: This randomized double blind, placebo-controlled crossover study investigated the antidyskinetic effects of levetiracetam in Parkinson's disease... CONCLUSIONS: Levetiracetam was well tolerated at doses up to 2000 mg per day, but we did not detect any antidyskinetic properties. (c) 2011 Movement Disorder Society. Copyright (c) 2011 Movement Disorder Society.
The anticonvulsant levetiracetam for the treatment of pain in polyneuropathy: a randomized, placebo-controlled, cross-over trial. [2011.07]
Levetiracetam is an anticonvulsant which is assumed to act by modulating neurotransmitter release via binding to the vesicle protein SV2A. This could have an impact on signaling in the nociceptive system, and a pilot study indicated relief of neuropathic pain with levetiracetam. OBJECTIVES: The aim of this study was to test the analgesic effect of levetiracetam in painful polyneuropathy... CONCLUSION: This study indicates that the anticonvulsant levetiracetam has no clinically relevant effect on painful polyneuropathy. Copyright (c) 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
Clinical Trials Related to Levetiracetam
Levetiracetam (Keppra) Tolerability in Cocaine Abusing Methadone-Maintained Patients. [Completed]
The proposed investigation will use methadone maintained patients who have concurrent cocaine
dependence in order to take advantage of the excellent (over 80%) treatment retention in this
patient group and to maximize treatment compliance by daily observed medication with both
methadone and levetiracetam. In the initial patients we will explore the tolerability of
escalating doses of levetiracetam as well as its potential role in reducing cocaine use, as
monitored by self-report and verified by three-times weekly urine toxicology testing in
methadone treated patients. The specific aim of this study is to evaluate the tolerability and
efficacy of levetiracetam 3 grams/day in modifying cocaine-using behavior, reducing cocaine
craving and attenuating cocaine's reinforcing effect among methadone-maintained patients
A Study Of The Safety And Efficacy Of Levetiracetam (Keppraź) (Ucb L059) In Children With Epilepsy [Completed]
The open-label study to allow pediatric patients who have participated in prior
Levetiracetam (Keppraź) studies to continue their treatment with adequate monitoring and
standardized follow-up care until Levetiracetam (Keppraź) is approved for use in children or
until the completion of the development program for pediatrics.
Long Term Follow-up Study With Levetiracetam XR (Keppra XR) for Partial Seizures [Enrolling by invitation]
To provide continued treatment of Keppra XR (Levetiracetam XR) and to assess the long term
safety of Keppra XR in patients with partial onset seizures.
Levetiracetam in the Treatment of Patients With Premenstrual Dysphoric Disorder (PMDD) [Completed]
An Open Long Term Follow up Study of L059 (Levetiracetam) in Epilepsy Patients With Partial Onset Seizures [Active, not recruiting]
This study is planned to evaluate the safety and efficacy of L059 (levetiracetam) in
long-term administration in patients who completed a previous study.
Reports of Suspected Levetiracetam Side Effects
Convulsion (165),
Product Substitution Issue (61),
Drug Ineffective (60),
Condition Aggravated (59),
Pregnancy (53),
Grand MAL Convulsion (46),
Aggression (44),
Petit MAL Epilepsy (40),
Somnolence (39),
Maternal Exposure During Pregnancy (39), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Levetiracetam has an overall score of 3. The effectiveness score is 8 and the side effect score is 2. The scores are on ten point scale: 10 - best, 1 - worst.
| | Levetiracetam review by 50 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | right temporal lobe epilepsy |
| Dosage & duration: | | 4000 daily (dosage frequency: 2000 mg. twice a day) for the period of I have been taking it for 9 mths. |
| Other conditions: | | hypothyroid, Atrial-Fib,Stroke-April '06 |
| Other drugs taken: | | syntroid, valium, coumadin, atenolol | | |
Reported Results |
| Benefits: | | In the beginning my seizures seemed to decrease, however at the time I was also on Depakote and Diamox as well as valium for right temporal lobe epilepsy; my doctor added keppra before he started weaning me off the depakote and diamox. I was feeling a lot better on all those meds. Then just the Keppra. |
| Side effects: | | Side effects= Intermittent Headaches,weakness,shaky and Double Vision, poor muscle coordination, problem with movement, walking, Abnormal Gait, behavioral changes, anger,weight loss, slurred speech, & memory loss. |
| Comments: | | I started on Keppra in Feb. '09, at first I thought it was the miracle drug. Boy was I wrong! At the time I was also on Depakote, Diamox and valium. First the Doctor added Keppra and began weaning me off the Depakote ER 500mg pm. 250mg. am. It took awhile to get off Depakote because I kept having effects from being weaned off it after being on it for 25 years. Then a few months later he started to wean me off of diamox, which I stopped a week ago, after a long process of being weaned off that drug. Now on Keppra alone with valium, I feel horrible and no heip from my Neurologist. I feel completely alone and with no help in sight! |
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Page last updated: 2013-05-16
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