DOSAGE AND ADMINISTRATION
Initiate treatment at 5 mg once daily with or without food, and consider increasing the dose to 10 mg once daily if 5 mg is tolerated.
Tablets may be administered with or without food. Tablets should not be split, crushed, or chewed. Doses higher than 10 mg once daily have not been studied in patients with pulmonary arterial hypertension (PAH). Liver function tests should be measured prior to initiation and during treatment with LETAIRIS [see Warnings and Precautions ].
Women of Childbearing Potential
Treat women of childbearing potential only after a negative pregnancy test and treat only women who are using two reliable methods of contraception unless the patient has had a tubal sterilization or a Copper T 380A IUD or LNg 20 IUD inserted. In those cases, no other contraception is needed. Pregnancy tests should be obtained monthly in women of childbearing potential taking LETAIRIS [see Contraindications].
Pre-existing Hepatic Impairment
LETAIRIS is not recommended in patients with moderate or severe hepatic impairment [see Special Populations]. Use caution in patients with mild hepatic impairment.
DOSAGE FORMS AND STRENGTHS
LETAIRIS is available as 5 mg and 10 mg film - coated, unscored tablets.