Latisse (Bimatoprost Ophthalmic) - Summary

LATISSE SUMMARY

LATISSE™ (bimatoprost ophthalmic solution) 0.03% is a synthetic prostaglandin analog.

LATISSE™ (bimatoprost ophthalmic solution) 0.03% is indicated to treat hypotrichosis of the eyelashes by increasing their growth including length, thickness and darkness.

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NEWS HIGHLIGHTS

Published Studies Related to Latisse (Bimatoprost Ophthalmic)

Eyelash growth in subjects treated with bimatoprost: a multicenter, randomized, double-masked, vehicle-controlled, parallel-group study. [2012]
topical administration to upper eyelid margins... CONCLUSION: Bimatoprost 0.03% was found to be effective at enhancing eyelashes in

Eyelash growth in subjects treated with bimatoprost: A multicenter, randomized, double-masked, vehicle-controlled, parallel-group study. [2011.09.05]
BACKGROUND: Bimatoprost 0.03% is associated with increased growth and prominence of eyelashes. OBJECTIVE: We sought to compare the safety and efficacy of once-daily bimatoprost 0.03% versus vehicle in increasing eyelash length, thickness, and darkness after topical administration to upper eyelid margins... CONCLUSION: Bimatoprost 0.03% was found to be effective at enhancing eyelashes in adults with a very good safety profile. Copyright (c) 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

The comparison of the effects of latanoprost, travoprost, and bimatoprost on central corneal thickness. [2011.08]
PURPOSE: To compare the effects of latanoprost, travoprost, and bimatoprost on central corneal thickness (CCT)... CONCLUSIONS: Topical therapy with prostaglandin analogues is associated with CCT reduction. Latanoprost, travoprost, and bimatoprost have a similar effect on CCT.

Twenty-four-hour intraocular pressure control with latanoprost-timolol-fixed combination versus bimatoprost in patients who switched from timolol. [2011]
(LTFC) over the 24-hour diurnal curve in patients who switched from timolol... CONCLUSIONS: The LTFC and bimatoprost therapies were equally effective in

Bimatoprost versus travoprost in an Egyptian population: a hospital-based prospective, randomized study. [2010.12]
PURPOSE: To compare the efficacy of bimatoprost and travoprost on intraocular pressure (IOP) reduction in an Egyptian population... CONCLUSION: Both drops lowered IOP effectively but bimatoprost showed a greater non-significant reductions in mean IOP from baseline.

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Clinical Trials Related to Latisse (Bimatoprost Ophthalmic)

Latisse (Bimatoprost .03% Opthalmic Solution) for the Treatment of Hypotrichosis of the Eyebrows: Latisse Versus Placebo [Recruiting]
The primary purpose of this study is to assess efficacy and safety of Latisse (bimatoprost .03% ophthalmic solution) applied to the lateral and medial eyebrows. The primary outcome is a increase in overall eyebrow prominence as measured by at least a 1-grade increase on the Global Eyebrow Assessment (GEyA) scale, from baseline to the end of the treatment which will be day 270 period.

Intraocular Pressure Reduction With the Bimatoprost/Timolol Fixed Combination [Recruiting]
The purpose of this study is to examine the ocular hypotensive effect of Bimatoprost and the potential additional effect of the Bimatoprost/Timolol fixed combination in eyes with ocular hypertension, primary open angle glaucoma or exfoliation glaucoma.

Safety and Efficacy of AGN-210961 Ophthalmic Solution Compared With Bimatoprost Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension [Recruiting]
This study has 2 parts. Part 1 will evaluate the safety and IOP effects of 6 formulations of AGN-210961 ophthalmic solution in the study eye and bimatoprost ophthalmic solution 0. 03% in the fellow eye for 7 consecutive days. Part 2 will evaluate the safety and IOP effects of a formulation (to be selected from part 1) of AGN-210961 in both eyes compared to bimatoprost ophthalmic solution 0. 03% for 4 weeks.

Bimatoprost in the Treatment of Eyelash Hypotrichosis [Recruiting]
This study will evaluate the safety and efficacy of bimatoprost solution formulation A compared with bimatoprost solution 0. 03% (LATISSE®) and vehicle in the treatment of eyelash hypotrichosis (inadequate eyelashes).

Effects of Latanoprost, Bimatoprost and Travoprost in Patients With Latanoprost-resistant Glaucoma [Recruiting]
Intraocular pressure (IOP) is considered to be the main risk factor for progression of glaucoma and therefore the main target of therapy. Pharmacologic treatment of glaucoma has changed considerably during the last decades due to the introduction of prostaglandin analogues. Three of these are commonly used in North America: latanoprost (Latanoprost T, Pfizer), Travoprost (Travatan TM, Alcon) and bimatoprost (Lumigan TM, Allergan).

There have been several studies to evaluate their effectiveness. The three seem to be equivalent, according to the only study that has compared the molecules. Latanoprost is employed initially, due to its paucity of side effects when compared to the other two analogues. However, if it is not effective, several studies ahve shown that a result is possible using either travoprost or bimatoprost. No study has been conducted to date systematically comparing the three molecules in cases of resistance to latanoprost. In actuality, the investigators patients will receive treatment identical to current practice with the exception of the group continuing with latanoprost. Several studies confirm the benefit of changing prostaglandin analogues if the first has not signficantly decreased the IOP (Palmberg et al. 2004). Each prostaglandin has unique properties which may cause the mechanism of action to vary slightly among patients. (cf. Pharmacological Aspects)

The goal of the study is thus to evaluate the efficaciousness of latanoprost, bimatoprost and travoprost in their IOP-lowering capacity in patients who do not initially respond to latanoprost.

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Reports of Suspected Latisse (Bimatoprost Ophthalmic) Side Effects

Madarosis (135),  Wrong Technique in Drug Usage Process (112),  Drug Ineffective (112),  Ocular Hyperaemia (106),  Erythema of Eyelid (83),  Eye Pruritus (78),  Trichorrhexis (67),  Eyelids Pruritus (56),  Inappropriate Schedule of Drug Administration (52),  Eye Irritation (51), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Latisse review by 33 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		eyelash loss
Dosage & duration:		one drop brushed on eyelash base (dosage frequency: 1x per day) for the period of 3mos
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		within a month of starting treatment eyelashes started to grow thicker, longer and darker
Side effects:		had occassional slight itching after application, but not consistently so and it wasn't all that bothersome
Comments:		put one drop of product on an eyeliner brush, then brushed across each eyelid at the base of the eyelashes. applied daily

Latisse review by 55 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		sparse eyelashes
Dosage & duration:		one drop nightly (dosage frequency: nightly) for the period of 1 year
Other conditions:		high blood preassure
Other drugs taken:		lisinopril 20 mg
		Reported Results
Benefits:		For the first time in my life I had enough lashes to apply mascara to. I had tried eyelash extensions which only broke off or pulled out what few thin lashes I did have. Strip lashes were itchy and uncomfortable. I now have normal lashes. Even though I only applied it to upper lashes the lower lashes have grown longer and thicker too.
Side effects:		My upper eyelids were red and itchy for the first 4-5 weeks but that went away and I have not had a problem since. My eye exams have been normal with eye preassure normal.
Comments:		For the first 6-8 weeks I used one drop every night applied to upper lash base with a small disposable brush. After my lashes had grown in I started using it every 2-3 nights instead of every night and the lashes have stayed longer and thicker than prior to treating them.

Latisse review by 55 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		sparse eyelashes
Dosage & duration:		one drop nightly (dosage frequency: nightly) for the period of 1 year
Other conditions:		high blood preassure
Other drugs taken:		lisinopril 20 mg
		Reported Results
Benefits:		For the first time in my life I had enough lashes to apply mascara to. I had tried eyelash extensions which only broke off or pulled out what few thin lashes I did have. Strip lashes were itchy and uncomfortable. I now have normal lashes. Even though I only applied it to upper lashes the lower lashes have grown longer and thicker too.
Side effects:		My upper eyelids were red and itchy for the first 4-5 weeks but that went away and I have not had a problem since. My eye exams have been normal with eye preassure normal.
Comments:		For the first 6-8 weeks I used one drop every night applied to upper lash base with a small disposable brush. After my lashes had grown in I started using it every 2-3 nights instead of every night and the lashes have stayed longer and thicker than prior to treating them.