LARIAM SUMMARY
LARIAM®
brand of
mefloquine hydrochloride
TABLETS
Lariam (mefloquine hydrochloride) is an antimalarial agent available as 250-mg tablets of mefloquine hydrochloride (equivalent to 228.0 mg of the free base) for oral administration.
Lariam is indicated for the treatment of mild to moderate acute malaria caused by mefloquine-susceptible strains of
P. falciparum
(both chloroquine-susceptible and resistant strains) or by
Plasmodium vivax. There are insufficient clinical data to document the effect of mefloquine in malaria caused by
P. ovale
or
P. malariae.
Note:
Patients with acute
P. vivax
malaria, treated with Lariam, are at high risk of relapse because Lariam does not eliminate exoerythrocytic (hepatic phase) parasites. To avoid relapse, after initial treatment of the acute infection with Lariam, patients should subsequently be treated with an 8-aminoquinoline derivative (eg, primaquine).
Lariam is indicated for the prophylaxis of
P. falciparum
and
P. vivax
malaria infections, including prophylaxis of chloroquine-resistant strains of
P. falciparum.
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NEWS HIGHLIGHTS
Published Studies Related to Lariam (Mefloquine)
Efficacy and effectiveness of mefloquine and artesunate combination therapy for uncomplicated Plasmodium falciparum malaria in the Peruvian Amazon. [2011.09]
We evaluated the efficacy and effectiveness of mefloquine (MQ) plus artesunate (AS) to treat patients with uncomplicated malaria in the Peruvian Amazon Basin in April 2005-March 2006. Patients >/= 1 year of age with fever (axillary temperature >/= 37.5 degrees C) or history of fever and Plasmodium falciparum monoinfection were included...
Effect of artesunate and mefloquine in combination on the Fridericia corrected QT intervals in Plasmodium falciparum infected adults from Thailand. [2011.04]
OBJECTIVE: To ascertain whether mefloquine (MQ) produces electrocardiogram (ECG) changes that could be a risk for Torsades de Pointe (TdP), a potentially malignant, ventricular tachyarrhythmia... CONCLUSIONS: In this small group of patients, slowing heart rates due to malaria resolution best explained the observed increases in the QTcF intervals. (c) 2011 Blackwell Publishing Ltd.
Artesunate/mefloquine paediatric formulation vs. artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum in Anonkoua koute, Cote d'Ivoire. [2011.03]
OBJECTIVES: To test the hypothesis that Artesunate-mefloquine paediatric (AS+MEF) is as effective as Artemether-lumefantrine (AL) in treating acute uncomplicated malaria in children... CONCLUSION: AS+MEF is as effective as AL, and both combinations were efficacious and safe. (c) 2011 Blackwell Publishing Ltd.
Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, open-label, phase 2 trial. [2011.02]
BACKGROUND: Praziquantel is the only drug available for treatment of Opisthorchis viverrini, although in-vivo studies point to activity of mefloquine, artesunate, and tribendimidine against this liver fluke. We aimed to assess the efficacy and safety of these drugs compared with that of praziquantel in patients with O viverrini infection... INTERPRETATION: Tribendimidine seems to be at least as efficacious as the drug of choice, praziquantel, for the treatment of O viverrini infections; both drugs were well tolerated. Mefloquine, artesunate, and mefloquine-artesunate did not show an effect. Tribendimidine should be further investigated with large clinical trials. FUNDING: Swiss National Science Foundation, University of Basel. Copyright (c) 2011 Elsevier Ltd. All rights reserved.
A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos. [2010.12]
We conducted an open, randomized clinical trial of oral dihydroartemisinin-piperaquine (DP) versus artesunate-mefloquine (AM) in 300 patients in Laos with uncomplicated Plasmodium falciparum malaria as part of a multicentre study in Asia. Survival analysis and adjustment for re-infection showed that the 63-day cure rates (95% confidence interval [CI]) were 100% for AM and 99.5% (96.4-99.8%) for DP...
Clinical Trials Related to Lariam (Mefloquine)
Phase I Factorial Trial of Temozolomide, Memantine, Mefloquine, and Metformin for Post-Radiation Therapy (RT) Glioblastoma Multiforme (GBM) [Recruiting]
The goal of this clinical research study is to find the highest tolerable dose of
temozolomide in combination with memantine, mefloquine, and/or metformin that can be given
to patients with glioblastoma who have already been given radiation and chemotherapy in
combination. The safety of these drug combinations will also be studied.
Temozolomide is designed to kill cancer cells by damaging DNA (the genetic material of
cells). The damaged DNA may cause tumor cell death.
Memantine is designed to block the activity of a protein found on the surface of cells that
may control tumor growth and survival. This may stop further spread of tumor cells.
Mefloquine is designed to block a protein that helps to clean the waste in the cells and to
destabilize the cell membrane. Blocking this protein may cause tumor cell death.
Metformin is designed to block a protein in tumor cells that is important in tumor growth
and blood vessel development. This may cause cell death or reduce the spread of the
disease.
Pharmacokinetics of Mefloquine-Artesunate in Pregnant Women With Uncomplicated Plasmodium Falciparum Infection [Not yet recruiting]
Artemisinin-based combination therapies (ACTs) are now the treatment of choice for malaria
in non-pregnant individuals living in areas with established chloroquine resistance; they
have been shown to be both safe and highly efficacious. There is rapidly increasing
experience with artemisinin derivatives in the 2nd and 3rd trimesters of pregnancy, with
over 1,000 well documented cases with no reported serious adverse effects to mother or fetus
(WHO Malaria Treatment Guidelines, 2006). Many countries in Latin America have abandoned the
previous 1st line regimen of Quinine-Clindamycin for treatment of malaria in pregnancy, a
complex and poorly tolerated regimen with low adherence, in favor of ACTs, despite limited
safety and pharmacokinetic data on the use of these compounds in pregnant women. Lack of
pharmacokinetic data may lead to underdosing of pregnant women, with subsequent reduced
efficacy and increased potential for development of resistance.
One ACT regimen, Artesunate-Mefloquine, has been developed as a fixed-dose combination
(Farmanguinhos Artesunato + Mefloquina), as part of an international collaborative research
effort led by Drugs for Neglected Diseases Initiative (DNDi), and manufactured by
Farmanguinhos, laboratory of the Brazilian Ministry of Health. Initial clinical trials
suggest that it is very well tolerated and efficacious in both pregnant and non-pregnant
individuals. The convenient dosing afforded by a fixed drug combination make this a very
promising candidate for treatment of pregnant women with malaria. Preliminary
pharmacokinetic data from mefloquine monotherapy and prophylaxis suggest that the peak
concentration of mefloquine is lowered in pregnant women. Prior to wide-spread adoption of
the Artesunate-Mefloquine combination, further studies on safety, efficacy, and dose
optimization are imperative. We propose to compare the pharmacokinetics of the fixed
combination of mefloquine-artesunate (MA) for treatment of P. falciparum in 28 pregnant women
in the second and third trimesters to the pharmacokinetics of this regimen in 28 matched
non-pregnant P. falciparum infected women. This will allow us to determine whether the
standard adult dose is sufficient for pregnant women.
Activity of Mefloquine Against Urinary Schistosomiasis [Not yet recruiting]
Urinary schistosomiasis is a debilitating disease in Central Africa and pregnant women are
frequently suffering from this condition. Mefloquine is currently investigated as preventive
treatment against malaria in pregnancy and mefloquine is also known to exert activity
against schistosomiasis. The investigators want to test the hypothesis whether mefloquine
may active against urinary schistosomiasis when used as preventive treatment against malaria
in pregnancy.
Effectiveness of the Association Artesunate and Mefloquine in the Treatment of Malaria by Plasmodium Falciparum [Recruiting]
The purpose of this study is to evaluate whether the fixed combination of
artesunate+mefloquine has been effective in the treatment of uncomplicated malaria caused by
Plasmodium falciparum at the Juruá Valley, Brazil, where it has been used.
Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine [Recruiting]
The purpose of this study is to evaluate the efficacy of cotrimoxazole prophylaxis in
prevention of malaria during pregnancy in HIV-infected women, compared to intermittent
preventive treatment with mefloquine.
Reports of Suspected Lariam (Mefloquine) Side Effects
Anxiety (18),
Depression (16),
Tinnitus (12),
Dizziness (12),
Anger (11),
Nightmare (11),
Suicidal Ideation (10),
Balance Disorder (10),
Sleep Disorder (10),
Paranoia (8), more >>
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Page last updated: 2011-12-09
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