Lariam (mefloquine hydrochloride) is an antimalarial agent available as 250-mg tablets of mefloquine hydrochloride (equivalent to 228.0 mg of the free base) for oral administration.
Lariam is indicated for the treatment of mild to moderate acute malaria caused by mefloquine-susceptible strains of
(both chloroquine-susceptible and resistant strains) or by
Plasmodium vivax. There are insufficient clinical data to document the effect of mefloquine in malaria caused by
Patients with acute
malaria, treated with Lariam, are at high risk of relapse because Lariam does not eliminate exoerythrocytic (hepatic phase) parasites. To avoid relapse, after initial treatment of the acute infection with Lariam, patients should subsequently be treated with an 8-aminoquinoline derivative (eg, primaquine).
Lariam is indicated for the prophylaxis of
malaria infections, including prophylaxis of chloroquine-resistant strains of
Published Studies Related to Lariam (Mefloquine)
Efficacy and effectiveness of mefloquine and artesunate combination therapy for uncomplicated Plasmodium falciparum malaria in the Peruvian Amazon. [2011.09]
We evaluated the efficacy and effectiveness of mefloquine (MQ) plus artesunate (AS) to treat patients with uncomplicated malaria in the Peruvian Amazon Basin in April 2005-March 2006. Patients >/= 1 year of age with fever (axillary temperature >/= 37.5 degrees C) or history of fever and Plasmodium falciparum monoinfection were included...
Effect of artesunate and mefloquine in combination on the Fridericia corrected QT intervals in Plasmodium falciparum infected adults from Thailand. [2011.04]
OBJECTIVE: To ascertain whether mefloquine (MQ) produces electrocardiogram (ECG) changes that could be a risk for Torsades de Pointe (TdP), a potentially malignant, ventricular tachyarrhythmia... CONCLUSIONS: In this small group of patients, slowing heart rates due to malaria resolution best explained the observed increases in the QTcF intervals. (c) 2011 Blackwell Publishing Ltd.
Artesunate/mefloquine paediatric formulation vs. artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum in Anonkoua koute, Cote d'Ivoire. [2011.03]
OBJECTIVES: To test the hypothesis that Artesunate-mefloquine paediatric (AS+MEF) is as effective as Artemether-lumefantrine (AL) in treating acute uncomplicated malaria in children... CONCLUSION: AS+MEF is as effective as AL, and both combinations were efficacious and safe. (c) 2011 Blackwell Publishing Ltd.
Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, open-label, phase 2 trial. [2011.02]
BACKGROUND: Praziquantel is the only drug available for treatment of Opisthorchis viverrini, although in-vivo studies point to activity of mefloquine, artesunate, and tribendimidine against this liver fluke. We aimed to assess the efficacy and safety of these drugs compared with that of praziquantel in patients with O viverrini infection... INTERPRETATION: Tribendimidine seems to be at least as efficacious as the drug of choice, praziquantel, for the treatment of O viverrini infections; both drugs were well tolerated. Mefloquine, artesunate, and mefloquine-artesunate did not show an effect. Tribendimidine should be further investigated with large clinical trials. FUNDING: Swiss National Science Foundation, University of Basel. Copyright (c) 2011 Elsevier Ltd. All rights reserved.
A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos. [2010.12]
We conducted an open, randomized clinical trial of oral dihydroartemisinin-piperaquine (DP) versus artesunate-mefloquine (AM) in 300 patients in Laos with uncomplicated Plasmodium falciparum malaria as part of a multicentre study in Asia. Survival analysis and adjustment for re-infection showed that the 63-day cure rates (95% confidence interval [CI]) were 100% for AM and 99.5% (96.4-99.8%) for DP...
Clinical Trials Related to Lariam (Mefloquine)
Phase I Factorial Trial of Temozolomide, Memantine, Mefloquine, and Metformin for Post-Radiation Therapy (RT) Glioblastoma Multiforme (GBM) [Recruiting]
The goal of this clinical research study is to find the highest tolerable dose of
temozolomide in combination with memantine, mefloquine, and/or metformin that can be given
to patients with glioblastoma who have already been given radiation and chemotherapy in
combination. The safety of these drug combinations will also be studied.
Temozolomide is designed to kill cancer cells by damaging DNA (the genetic material of
cells). The damaged DNA may cause tumor cell death.
Memantine is designed to block the activity of a protein found on the surface of cells that
may control tumor growth and survival. This may stop further spread of tumor cells.
Mefloquine is designed to block a protein that helps to clean the waste in the cells and to
destabilize the cell membrane. Blocking this protein may cause tumor cell death.
Metformin is designed to block a protein in tumor cells that is important in tumor growth
and blood vessel development. This may cause cell death or reduce the spread of the
Study to Explore the Effect of Mefloquine in Participants With Progressive Multifocal Leukoencephalopathy (PML) [Terminated]
The primary objective of the study was to explore whether mefloquine can delay or stop
progression of progressive multifocal leukoencephalopathy (PML) as measured by JC virus
(human polyomavirus or JCV) deoxyribonucleic acid (DNA) levels in cerebrospinal fluid (CSF).
The secondary objective of the study was to explore whether mefloquine can delay or stop
progression of PML based on neurological deterioration, magnetic resonance imaging (MRI)
measures of brain lesion evolution or the formation of new lesions, and mortality.
Study to Investigate the Safety, Tolerability and Pharmacokinetics of AD 452 [(+)-Mefloquine] Compared With Racemic Mefloquine [Completed]
Mefloquine is a quinolinemethanol antimalarial that is effective as therapy and prophylaxis
for all species of malaria infecting humans, including multi-drug resistant Plasmodium
falciparum. The marketed anti-malaria drug consists of two enantiomers of mefloquine.
Mefloquine's clinical utility has been impaired by its association with neuropsychiatric
side effects. The pharmacological basis of mefloquine's side effects is not known but two of
the most reported hypotheses relate to its action on (i) the adenosine receptor and (ii) its
effect on the cholinesterase enzyme. For both of these mechanisms, there is a significant
stereoselective activity of the two enantiomers. In vitro studies show that the (-) isomer
is 50-100 fold more potent towards adenosine receptors compared with the (+) isomer. In
addition, (-)-mefloquine has considerably more anti-cholinesterase activity. It has
therefore been hypothesised that (+)-mefloquine may have a better central nervous system
(CNS) safety profile compared with either the racemate or (-)-mefloquine.
This study is a randomized, ascending dose, double-blind, active and placebo-controlled,
parallel group study in healthy male and female volunteers designed to investigate this
hypothesis and to describe the comparative pharmacokinetics of the racemate and the single
Efficacy of Artesunate-Mefloquine Combination Therapy in Trat Province, Thailand [Completed]
Assessment of Artesunate/Mefloquine in the Peruvian Amazon [Not yet recruiting]
There is growing evidence of the emergence of P. falciparum resistance to artesunate (a
derivative of artemisin) in Southeast Asia. The emergence and spread of resistant strains to
artemisinin would represent an alarming threat to the success of the antimalarial
combination therapy in the region. The delayed clearance of parasitemia for more than 24
hours has been taken as an early sign of resistance, a phenomenon seen at the Thai-Cambodia
The purpose of this research study, is to assess the in vitro and in vivo efficacy of
combinated artesunate/mefloquine therapy to treatment of uncomplicated Plasmodium falciparum
malaria in the Peruvian Amazon through the analysis of the rate of clearance of parasitemia
and other important outcomes.
Reports of Suspected Lariam (Mefloquine) Side Effects
Suicidal Ideation (10),
Balance Disorder (10),
Sleep Disorder (10),
Paranoia (8), more >>
Page last updated: 2011-12-09