LANOXIN (digoxin) is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants. Digoxin is extracted from the leaves of Digitalis lanata. The term digitalis is used to designate the whole group of glycosides. The glycosides are composed of 2 portions: a sugar and a cardenolide (hence glycosides).
Heart Failure in Adults
LANOXIN is indicated for the treatment of mild to moderate heart failure in adults. LANOXIN increases left ventricular ejection fraction and improves heart failure symptoms as evidenced by improved exercise capacity and decreased heart failure-related hospitalizations and emergency care, while having no effect on mortality. Where possible, LANOXIN should be used in combination with a diuretic and an angiotensin-converting enzyme (ACE) inhibitor.
Heart Failure in Pediatric Patients
Digoxin increases myocardial contractility in pediatric patients with heart failure.
Atrial Fibrillation in Adults
LANOXIN is indicated for the control of ventricular response rate in adult patients with chronic atrial fibrillation.
Media Articles Related to Lanoxin (Digoxin)
Heart Drug Digoxin May Not Be Best for Some Heart Patients
Source: MedicineNet digoxin Specialty [2015.05.06]
Title: Heart Drug Digoxin May Not Be Best for Some Heart Patients
Category: Health News
Created: 5/5/2015 12:00:00 AM
Last Editorial Review: 5/6/2015 12:00:00 AM
Alcohol abuse may predict congestive heart failure; even among younger adults
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2015.11.10]
Alcohol abuse was associated with a 70 percent increased risk of congestive heart failure in adults and the link was especially strong among younger adults (60 years or younger) and those without...
Thiazide may pose some risk for congestive heart failure patients
Source: Hypertension News From Medical News Today [2015.11.09]
Thiazide, a popular diuretic for lowering high blood pressure, may not excrete salt as expected in patients with congestive heart failure and or dehydration and should be taken with caution, say...
Congestive Heart Failure (CHF)
Source: MedicineNet bumetanide Specialty [2014.12.29]
Title: Congestive Heart Failure (CHF)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 12/29/2014 12:00:00 AM
Congestive Heart Failure
Source: MedicineNet Impotence (ED) Specialty [2013.10.08]
Title: Congestive Heart Failure
Category: Diseases and Conditions
Created: 10/16/2013 7:54:00 PM
Last Editorial Review: 10/8/2013 12:00:00 AM
Published Studies Related to Lanoxin (Digoxin)
Darexaban (YM150), an oral direct factor Xa inhibitor, has no effect on the
pharmacokinetics of digoxin. 
To investigate the impact of the direct Factor Xa inhibitor darexaban
administered in a modified-release formulation (darexaban-MR) on the
pharmacokinetic (PK) profile of digoxin. In this Phase I, randomized,
double-blind, two-period crossover study (8 days for each treatment, 10 days
washout), 24 healthy subjects received darexaban-MR 120 mg once/day (qd) +
digoxin 0.25 mg qd in one treatment period, and placebo + digoxin 0.25 mg qd in
the other treatment period...
Effect of lacosamide on the steady-state pharmacokinetics of digoxin: results
from a phase I, multiple-dose, double-blind, randomised, placebo-controlled,
crossover trial. 
with lacosamide or placebo... CONCLUSION: Co-administration of steady-state digoxin (0.25 mg/day) with
The study of antiarrhythmic medications in infancy (SAMIS): a multicenter,
randomized controlled trial comparing the efficacy and safety of digoxin versus
propranolol for prophylaxis of supraventricular tachycardia in infants. 
CONCLUSIONS: There was no difference in SVT recurrence in infants treated with
Evaluation of the pharmacokinetic interaction after multiple oral doses of linagliptin and digoxin in healthy volunteers. [2011.03]
The aim of this study was to investigate whether multiple doses of the oral and highly selective dipeptidyl peptidase-4 inhibitor linagliptin affect the steady-state pharmacokinetics of the P-glycoprotein substrate digoxin. This single-center, open-label, two-period cross-over study involved healthy subjects (n = 20), randomized to treatment sequence AB or BA, where A comprised 0.25 mg digoxin qd for 5 days, then 0.25 mg digoxin qd plus 5 mg linagliptin qd for 6 days, and B comprised 0.25 mg digoxin qd for 11 days...
Digoxin for preventing or treating neonatal respiratory distress syndrome. [2011.01.19]
CONCLUSIONS: Although hemodynamic disturbances play a role in the overall pathogenesis of respiratory distress syndrome, the specific contribution of early congestive heart failure (unrelated to hemodynamically significant patent ductus arteriosus) does not appear to be a significant factor in RDS. Treatment with digoxin has no proven value in infants solely affected with RDS.
Clinical Trials Related to Lanoxin (Digoxin)
Digoxin Dosing in Heart Failure: A Simplified Nomogram Versus Standard Care [Completed]
Dosing methods for digoxin, a drug used to treat heart failure, have not been updated in
decades despite evidence in recent years suggesting that blood levels of digoxin achieved
with traditional dosing practices may increase the risk of adverse events. We developed a
simple dosing tool that targets lower blood levels of digoxin that have been associated with
improved outcomes compared to higher blood levels. The aim of this study is to determine if
this simplified dosing tool is more effective than standard digoxin dosing practices at
achieving lower blood levels and also to determine if digoxin dosing may be further
optimized by incorporating patients' genetic information believed to influence the drug's
Drug Interaction Study of Isavuconazole and Digoxin [Completed]
A Study to Assess the Effects of Canagliflozin (JNJ-28431754) on the Pharmacokinetics and Safety of Digoxin in Healthy Volunteers. [Completed]
The purpose of this study is to determine how multiple doses of canagliflozin (JNJ-28431754)
affect the pharmacokinetics (ie, how the body affects the drug) of multiple doses of
digoxin. The safety and tolerability of canagliflozin will also be assessed in healthy
Study to Evaluate the Effect of Solifenacin and Mirabegron on the Digoxin Concentrations in Blood in Healthy Subjects [Completed]
The purpose of this study is to evaluate the effect of steady state solifenacin and
mirabegron on the pharmacokinetics of co-administered steady state digoxin. This study will
also evaluate the safety and tolerability of the combined steady state administration of
solifenacin, mirabegron and digoxin.
A Trial of Digoxin Before Second-Trimester Abortion [Completed]
Reports of Suspected Lanoxin (Digoxin) Side Effects
Toxicity TO Various Agents (16),
Cardiac Failure Congestive (5),
Atrial Fibrillation (5),
Asthenia (5), more >>