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Lanoxin (Digoxin) - Summary

 

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LANOXIN SUMMARY

LANOXIN®
(digoxin) Tablets, USP
 mcg (0.125 mg) Scored I.D. Imprint Y3B (yellow)
 mcg (0.25 mg) Scored I.D. Imprint X3A (white)

LANOXIN (digoxin) is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants. Digoxin is extracted from the leaves of Digitalis lanata. The term "digitalis" is used to designate the whole group of glycosides. The glycosides are composed of two portions: a sugar and a cardenolide (hence "glycosides").

Heart Failure:    LANOXIN is indicated for the treatment of mild to moderate heart failure. LANOXIN increases left ventricular ejection fraction and improves heart failure symptoms as evidenced by exercise capacity and heart failure-related hospitalizations and emergency care, while having no effect on mortality. Where possible, LANOXIN should be used with a diuretic and an angiotensin-converting enzyme inhibitor, but an optimal order for starting these three drugs cannot be specified.

Atrial Fibrillation:    LANOXIN is indicated for the control of ventricular response rate in patients with chronic atrial fibrillation.

LANOXIN NEWS HIGHLIGHTS

Media Articles Related to Lanoxin (Digoxin)

Congestive Heart Failure
Source: MedicineNet Amyloidosis Specialty [2008.06.23]

New Diagnostic Tools And Biomarkers
Source: Respiratory / Asthma News From Medical News Today [2008.09.03]

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Published Studies Related to Lanoxin (Digoxin)

No effect of imidafenacin, a novel antimuscarinic drug, on digoxin pharmacokinetics in healthy subjects. [2008]

Intravenous and oral administration of amiodarone for the treatment of recent onset atrial fibrillation after digoxin administration. [2007.10.18]

Digoxin bioequivalence study: determination in human plasma by microparticle enzyme immunoassay. [2007.06]

Digoxin and reduction in mortality and hospitalization in geriatric heart failure: importance of low doses and low serum concentrations. [2007.03]

Verapamil versus digoxin and acute versus routine serial cardioversion for the improvement of rhythm control for persistent atrial fibrillation. [2006.09.05]

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Clinical Trials Related to Lanoxin (Digoxin)

Drug Interaction Study - Effect of AZD5672 on the Pharmacokinetics of Digoxin [Recruiting]

Pharmacokinetic and Pharmacodynamic Interaction Study of Digoxin and Hawthorn [Completed]

An Interaction Study With Digoxin and AZD1305 [Not yet recruiting]

Second Line Erlotinib (Tarceva) Plus Digoxin in Non-Small Cell Lung Cancer [Recruiting]

Study To Examine The Effects Of Lapatinib On The Pharmacokinetics Of Digoxin In Subjects w/ ErbB2 Positive Breast Cancer [Recruiting]

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Page last updated: 2008-09-03

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